Major study launches to track heart risks in transgender people on hormones

NCT ID NCT07187947

Recruiting now Knowledge-focused Sponsor: IRCCS Azienda Ospedaliero-Universitaria di Bologna Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study will follow 500 transgender adults who have been on gender-affirming hormone therapy for at least a year. Researchers will measure changes in blood pressure, cholesterol, body composition, and other heart health markers. The goal is to understand the long-term cardiovascular effects of hormone therapy and improve care for transgender individuals.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: gender-affirming hormone therapy (estradiol, antiandrogens, or testosterone)
What this could lead to: If successful, this study could provide clear data on how hormone therapy affects heart health in transgender individuals, helping doctors tailor safer treatment plans.
What could go wrong: This is an observational study, not a treatment trial, so it won't directly test a new drug or cure. Results may take years and could still leave many questions unanswered.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cardiovascular disorder Gender Dysphoria

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARDIOVASCULAR (CV) RISK CARDIOVASCULAR DISEASE (CVD) CARDIOVASCULAR DISEASE ACUTE CARDIOVASCULAR DISEASE PREVENTION CARDIOVASCULAR DISEASE RISK FACTOR CARDIOVASCULAR HEALTH STATUS GENDER INCONGRUENCE

Contacts and locations

Locations

IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola
RECRUITING

Bologna, BO, 40138, Italy

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