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Could a diabetes drug protect obese Teens' hearts?

NCT ID NCT06967389

Recruiting now Disease control Sponsor: John Bauer Source: ClinicalTrials.gov ↗

First seen Jul 21, 2026 · Last updated Jul 22, 2026 · Updated 1 time

Summary

This study tests whether semaglutide, a drug used for weight loss, can reduce markers of heart disease risk in adolescents aged 12 to 15 with severe obesity (class 2 or 3). Participants receive semaglutide and undergo heart scans, body composition tests, and blood work over about a year. The goal is to see how weight loss, body changes, and heart function interact, and whether there are differences between boys and girls.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
semaglutide (the drug in Ozempic)
What this could lead to
If successful, this could show that semaglutide helps lower cardiovascular disease risk in severely obese adolescents, potentially guiding future treatment guidelines.
What could go wrong
This is a small, early-stage study with only 50 participants, so results may not apply to all teens. The drug may cause side effects like nausea or vomiting, and long-term benefits are not yet proven.

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Conditions

The condition(s) this trial relates to.

morbid obesity Obesity obesity disorder Overweight Weight Loss

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARDIOVASCULAR DISEASE RISK FACTOR OBESE ADOLESCENTS OBESITY AND OVERWEIGHT WEIGHT LOSS WEIGHT MANAGEMENT

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • University of Kentucky

    RECRUITING

    Lexington, Kentucky, 40506, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

    Contact

    Contact

    Contact

    Contact

    Contact

    Contact Email: •••••@•••••

    Contact

    Contact

    Contact

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