OBESITY AND OVERWEIGHT

This study tests whether a daily postbiotic supplement called resM™ can help overweight adults lose weight and improve metabolic health. About 80 participants will take either the supplement or a placebo for a set period. Researchers will measure changes in weight, BMI, food crav…

This study tests whether tirzepatide, a drug used for diabetes and weight loss, can help adults with obesity and binge-eating disorder. About 105 participants will receive tirzepatide, a placebo, or another drug (lisdexamfetamine), plus guided self-help therapy. The main goals ar…

This study is testing whether tirzepatide, a drug already used for diabetes and weight loss, can help overweight or obese people with well-controlled HIV lose weight and reduce chronic inflammation. Twelve adults will receive weekly injections for 12 weeks, with doses gradually i…

This study looks at how adding exercise to anti-obesity medications affects body composition, like muscle and fat. About 40 adults taking weight-loss drugs will either do no extra exercise, aerobic training, or resistance training for 6 months. Researchers will measure changes in…

This study compares three different programs to help pregnant women maintain a healthy weight and avoid keeping on too much weight after giving birth. About 795 women who are early in pregnancy will join one of two special programs or receive standard care. The programs provide n…

This study looks at whether eating one cup of broccoli microgreens every day for two weeks can improve health in 24 obese breast cancer survivors. The goal is to see if this simple diet change can help reduce inflammation and improve metabolism, which may lower the risk of cancer…

This study tests an investigational drug called efsubaglutide alfa (YN-011) to see if it helps people with overweight or obesity lose weight safely. About 200 adults aged 18 to 75 will receive weekly injections of the drug or a placebo for 22 weeks. The main goal is to measure ho…

This study tests whether a weekly injection of tirzepatide (a drug used for diabetes and weight loss) can reduce heavy drinking and improve health in 42 adults who have both alcohol use disorder and overweight or obesity. Participants will receive either tirzepatide or a placebo …

This study looks at whether eating fresh watermelon every day for 6 weeks can improve gut health and heart health in young adults (ages 18–30) who are overweight or have obesity. Participants will eat either watermelon or a low-fat snack and have their gut bacteria, blood pressur…

This study tests a new once-weekly injection called MET097 in 3500 adults with obesity or overweight who also have weight-related health issues like high blood pressure or sleep apnea. The goal is to see how much weight participants lose over 64 weeks and whether the treatment is…

This study tests whether a program combining a reduced-calorie Mediterranean diet with increased physical activity can help middle-aged adults (30-50 years old) with metabolic syndrome lose weight and maintain that loss for a year. Researchers will compare this lifestyle interven…

This early-stage study is testing a new drug called WVE-007 in 136 adults with overweight or obesity (BMI 28-35). The main goal is to check if the drug is safe and how the body handles it. Participants will receive either the drug or a placebo as a single injection, and researche…

This study looks at whether adding stair climbing to daily routines can lower blood pressure more than brisk walking alone. About 450 adults with high blood pressure, overweight, and a sedentary lifestyle will be split into three groups: stair walking plus brisk walking, brisk wa…

This study tests whether a diet tailored to a person's unique metabolism (called a 'metabotype') can prevent type 2 diabetes better than standard dietary advice. Researchers will enroll 240 adults with overweight or obesity who are at risk for diabetes. Participants will follow e…

This study looks at whether eating only during an 8-hour window each day (16-hour fast) can help women going through menopause—either naturally or after breast cancer treatment—lose weight, reduce belly fat, and ease menopause symptoms. 84 women will be randomly assigned to eithe…

This study is testing a smartphone app designed to help teenagers with obesity lose weight. The app is based on the idea that replacing unhealthy eating habits with healthy coping skills can lead to weight loss. About 38 teens aged 14-21 will try the app and provide feedback on h…

This study looks at whether teaching teens with overweight or obesity how to sleep better can help them lose more weight when combined with standard care. About 126 teens aged 13 to 17 with poor sleep will be split into two groups: one gets usual weight-loss advice, and the other…

This study tests a 6-month mobile program that combines group support, coaching, and activity tracking to help older adults with knee or hip osteoarthritis become more active and lose weight. Researchers want to see if it reduces pain interference and improves physical function. …

This study tests a behavioral weight loss program for college students who are overweight or have obesity. The program uses a 'small change' approach to help participants lose weight. Researchers want to see if students find the program acceptable and if it leads to meaningful we…

This study looks at whether adding yoga to a standard weight loss program helps adults with overweight or obesity lose more weight. About 290 participants will follow a 12-month program with diet changes and either aerobic exercise alone or aerobic exercise plus yoga. Researchers…

This study looks at how eating a lot of ultra-processed foods (like packaged snacks and sugary drinks) affects the way your body absorbs calories. Researchers will compare two diets: one where 80% of calories come from ultra-processed foods and another where only 20% do. They wil…

This study looks at how the gut's fermentation process affects insulin resistance in teenagers and young adults with obesity. Researchers will give a sugar drink (lactulose) to see how it changes fat breakdown and sugar production in the body. The goal is to better understand the…

This study follows 100 adults who are starting anti-obesity medications like semaglutide or tirzepatide. Researchers will measure changes in body fat, muscle, and strength over time, and look at how diet and exercise influence results. The goal is to understand the real-world imp…

This study looks at why some children develop obesity by examining brain activity, eating habits, and genetics. Researchers will follow 210 children aged 7-12 from an existing study, using lab tests and MRI scans to measure how the brain responds to food. The goal is to find earl…

This study looks at whether eating peanuts every day can improve bone health, metabolism, and physical function in overweight older adults (ages 50-75) who are trying to lose weight. Participants will be randomly assigned to eat either a daily peanut snack or a nut-free snack for…

This study looks at 200 adults who need a second weight-loss surgery (revision bariatric surgery) to see if using a robot or standard laparoscopic tools leads to fewer complications. The main goal is to compare rates of problems like leaks, bleeding, and infections between the tw…

This study examines 100 children aged 3 to 15 who have had a minor injury to see if low vitamin D, bone markers, or being overweight are linked to fractures. Researchers will compare blood tests and body measurements between those with a broken bone and those without. The goal is…

This study follows about 4,000 adults from Shanghai communities to see how heart, kidney, and metabolic diseases develop over time. Researchers will compare current health data with information collected between 2016 and 2017. The goal is to understand how risk factors change and…

This study compares two training programs for doctors and health workers at community health centers that serve Medicaid patients. The goal is to see which training helps patients lose more weight and get better access to obesity care. About 6,200 patients and their providers wil…