OBESITY AND OVERWEIGHT

This large phase 3 trial is testing a new once-weekly injection called MET097 for weight loss in 3501 adults with obesity or overweight (but without diabetes). Participants will receive either the drug or a placebo for up to 84 weeks. The main goal is to see how much weight peopl…

This early-stage study tests a new drug, WVE-007, given as a shot under the skin to help with weight loss. It includes about 296 adults who are overweight or have obesity, some with pre-diabetes or type 2 diabetes. The main goal is to check safety and how the drug moves through t…

This study tests whether taking a probiotic for 3 months can improve how the body processes fats after a meal in adults aged 50-70 who are overweight or moderately obese but otherwise healthy. 66 participants will receive either the probiotic or a placebo. The main goal is to see…

This study tests if tirzepatide, a weekly injection, can help overweight or obese people with well-controlled HIV lose weight and reduce chronic inflammation. Twelve adults will receive increasing doses over 12 weeks, with a 4-week safety follow-up. Researchers will measure chang…

This study looks at what happens to your body when you take anti-obesity medications like semaglutide or tirzepatide, and whether adding aerobic or resistance exercise helps preserve muscle and bone while losing fat. About 40 adults will be assigned to either standard care (medic…

This study is testing whether eating 2.5 cups of fresh watermelon every day for six weeks can improve gut health, including increasing good bacteria, and boost heart health in young adults aged 18-30 who are overweight or have obesity. Participants will be randomly assigned to ea…

This study tests whether a reduced-calorie Mediterranean diet plus regular exercise helps middle-aged adults (30-50 years) with metabolic syndrome lose weight and keep it off. About 106 participants will either follow this lifestyle program or receive standard care. Researchers w…

This study compares three approaches to help pregnant women and new mothers maintain a healthy weight. About 795 participants will receive either self-management support via mobile app or mail, community-based help from health workers, or usual care. The goal is to see which meth…

This study tests whether adding stair climbing to a brisk walking routine lowers blood pressure more than walking alone. 450 adults with high blood pressure, overweight, and a sedentary lifestyle will be split into three groups: stair walking plus brisk walking, brisk walking onl…

This study tests a new drug called efsubaglutide alfa for weight loss in 200 adults who are overweight or obese. Participants receive weekly or biweekly injections for 22 weeks, and researchers measure how much weight they lose. The goal is to see if the drug is safe and effectiv…

This study tests whether a weekly injection of tirzepatide, a drug used for diabetes and weight loss, can help adults with alcohol use disorder and overweight or obesity reduce heavy drinking. About 42 participants will receive either the drug or a placebo for 8 weeks. The main g…

This phase 2 trial tests whether tirzepatide, a drug used for diabetes and weight loss, can reduce binge-eating episodes and help with weight loss in adults with obesity and binge-eating disorder. About 105 participants will receive tirzepatide, a placebo, or the existing drug li…

This study is testing a postbiotic supplement called resM™ GLP-1 Postbiotic to see if it helps overweight adults lose weight and improve their metabolic health. The supplement contains vitamins, minerals, and plant extracts. Researchers will measure changes in weight, BMI, food c…

This study tests whether a diet tailored to a person's unique metabolism (called a 'metabotype') can prevent type 2 diabetes better than standard healthy eating advice. Overweight or obese adults at risk for diabetes will follow either a personalized or standard diet for 12 month…

This study is testing whether a time-restricted eating plan (eating only during an 8-10 hour window each day) combined with a healthy plant-based diet is safe and doable for people with liver cancer, cirrhosis, or fatty liver disease. Fifty overweight or obese adults will either …

This study tests whether a 6-month mobile program can help 200 older adults (65+) with knee or hip arthritis pain become more active, lose weight, and feel less pain. Participants will join weekly group or individual coaching calls and track their steps. After the program, they w…

This study tests if eating only during an 8-hour window each day (16-hour fast) helps menopausal women lose weight and reduce menopause symptoms. It includes women going through natural menopause or those with hormone-sensitive breast cancer. 84 participants will be randomly assi…

This study looks at whether adding yoga to a standard weight loss program helps adults with overweight or obesity lose more weight than just aerobic exercise alone. About 290 participants will follow a 12-month program with diet changes and either aerobic exercise plus yoga or ae…

This pilot study tests a smartphone app called BrainWeighve that helps teens aged 14-21 with obesity lose weight by replacing overeating with healthier coping behaviors. The study enrolls 38 participants to test the app's feasibility and satisfaction over 4 months. It is an early…

This study looks at whether teaching teens with overweight or obesity how to sleep better can help them lose more weight when combined with standard diet and exercise advice. About 126 teens aged 13 to 17 who have poor sleep will join. Half will get usual care, and the other half…

This study tests a weight loss program for college students who are overweight or have obesity. The program focuses on making small, manageable changes to eating and activity. Researchers want to see if students find the program acceptable and if it leads to meaningful weight los…

This study follows 165 adults undergoing bariatric surgery to see if certain pre-surgery traits—like anxiety, depression, eating behaviors, and weight-related quality of life—can predict how their quality of life changes over the two years after surgery. Participants complete que…

This study looks at two different training programs for doctors and health workers at community health centers. The goal is to see which training helps patients lose weight better and get more people to use weight management services. About 6,200 adults and youth on Medicaid will…

This observational study will follow 100 adults starting anti-obesity medications like semaglutide or tirzepatide. Researchers will track changes in body fat, lean muscle, bone density, handgrip strength, and nutrition over time. The goal is to understand the real-world effects o…

This study looks at whether eating peanuts every day can improve bone health, metabolism, and physical function in overweight or obese adults aged 50-75 during a 6-month weight loss program. Participants will be randomly assigned to eat either a daily peanut snack or a nut-free s…

This study looks at why some children become overweight or obese by examining their eating habits, brain activity, and family history. Researchers will measure how kids' brains respond to food and how well they control their eating. The goal is to find early clues that could lead…

This study looks at how the fermentation of food in the gut affects metabolism in young people aged 15–22 with obesity. Researchers will give participants a sugar called lactulose to trigger fermentation and measure changes in fat breakdown and sugar production. The goal is to un…

This study looks at whether eating one cup of broccoli microgreens daily for two weeks is practical and beneficial for obese breast cancer survivors. Researchers will measure how well participants stick to the diet and track changes in body fat, blood sugar, and inflammation. The…

This study looks at how eating lots of ultra-processed foods (like packaged snacks and sugary drinks) affects the calories your body absorbs. Twenty adults with overweight or obesity will eat either a diet where 80% of calories come from ultra-processed foods or one where only 20…

This study looks at 200 adults who need a second weight-loss surgery (revision bariatric surgery) to see if using a robot or standard laparoscopy leads to fewer complications. The main focus is on problems like leaks, bleeding, and infections. Researchers will also compare pain, …

This study follows 4,094 adults in Shanghai who were part of an earlier health survey. Researchers will track them for up to 10 years to see how heart disease, kidney problems, and metabolic conditions like diabetes and obesity develop and interact. The goal is to better understa…

This study is looking at 100 children aged 3 to 15 who have had a low-energy fracture (like a fall from standing height). Researchers want to see if vitamin D levels, bone markers, and weight are linked to fracture risk. They will compare children with fractures to those without.…