OBESITY AND OVERWEIGHT

This study is testing a postbiotic supplement called resM™ GLP-1 Postbiotic to see if it helps overweight adults lose weight and improve their metabolic health. The supplement contains vitamins, minerals, and plant extracts. Researchers will measure changes in weight, BMI, food c…

This study tests whether restricting carbohydrates on two consecutive days per week or after 4pm each day can improve metabolic health and energy balance in adults with abdominal overweight or obesity. Over four weeks, participants follow one of these eating patterns or their usu…

This study tests an experimental drug called GZR18, given as an injection every two weeks, to help people with obesity or overweight lose weight. It compares three doses of GZR18 against a placebo and an existing weekly weight-loss drug, tirzepatide. Participants do not have type…

This study tests if tirzepatide, a weekly injection, can help overweight or obese people with well-controlled HIV lose weight and reduce chronic inflammation. Twelve adults will receive increasing doses over 12 weeks, with a 4-week safety follow-up. Researchers will measure chang…

This trial investigates whether changing how often and when people with type 2 diabetes eat can improve weight, blood sugar, and cholesterol. Over 12 weeks, participants follow one of three eating plans: a standard 6-meal diet, a 3-meal diet, or time-restricted eating (eating all…

This early-stage trial tested a new weekly injection called MET233 in 144 otherwise healthy adults with overweight or obesity. The main goal was to check safety and how the drug moves through the body. Researchers also looked at different dosing schedules over several weeks. Sinc…

This study compared three commercial weight management programs to see which helps adults with overweight or obesity lose the most weight in 12 weeks. 459 participants were randomly assigned to one of the programs. The main goal was to measure weight change and percentage of body…

This study tested a polyphenol-enriched supplement in 70 overweight or obese adults to see if it could improve body weight, fat mass, and metabolic health. Participants took either the active supplement or a placebo for a period, and researchers measured changes in weight, insuli…

This study tests a new drug called MET097, given as a weekly injection, to see if it is safe and helps with weight loss in adults who are overweight or obese but otherwise healthy. About 120 participants will receive either MET097 or a placebo for up to 12 weeks, with some explor…

This study tested whether a supplement called BK329 can help reduce body fat in adults who are overweight or have obesity. One hundred participants took either BK329 or a placebo for 12 weeks. Researchers measured changes in total body fat, weight, and other health markers to see…

This study looked at whether eating sorghum rice instead of white rice for one week could improve health in people with prediabetes. Twenty-six police officers with prediabetes took part. Half ate sorghum rice, and half ate white rice. The researchers measured changes in a hormon…

This early-stage study tested a single dose of an investigational drug called HDM1005 in 65 healthy adults who were overweight or had obesity. The main goal was to check if the injection is safe and how the body processes it. Researchers also looked at changes in weight and other…

This study tested whether repetitive transcranial magnetic stimulation (rTMS) can help overweight and obese adults lose weight and reduce food cravings. Fifty participants received either real rTMS, fake rTMS, or no treatment over 5 weeks. The goal was to see if stimulating a spe…

This study tested a ChatGPT-supported online group program to help overweight female nurses manage emotional and binge eating. Forty-four nurses participated in a randomized trial, with the intervention group attending online sessions guided by a self-help program and ChatGPT. Th…

This study examines why some people with obesity find it hard to lose weight, while lean individuals struggle to gain weight. Researchers measure how the body uses energy during fasting and after a special low-protein meal. By comparing these responses, they aim to identify diffe…

This study tested whether raising ketone levels—either through a ketogenic diet or a ketone supplement—can improve markers of obesity-related disease risk in overweight adults. Sixty-nine participants followed either a keto diet or took a ketone drink for four weeks. Researchers …

This study examined the link between obesity and iron deficiency anemia in 165 nonpregnant Indonesian women aged 19-29. Participants took daily iron-folic acid supplements for 90 days. Researchers compared iron levels between overweight/obese and normal-weight women to see if wei…

This study looked at how eating ultra-processed versus unprocessed foods changes the body's stress hormone (cortisol) levels. Twenty healthy men ate two different meals with the same calories and nutrients, and researchers measured their blood cortisol and other metabolic markers…

This study tested whether showing calorie information on alcohol or reducing serving sizes can lower how much people drink. Over 300 regular drinkers took part in a real-world pub quiz setting. Researchers measured alcohol units and total calories consumed during the evening.

This completed study looked at how a low-calorie diet changes the activity of certain genes in white blood cells and affects heart health markers in 60 people with high triglycerides and overweight. Researchers compared those who lost more weight to those who lost less, to unders…

This study looked at 36 adults with severe obesity who had laparoscopic sleeve gastrectomy, a type of weight-loss surgery. Researchers measured blood levels of a hormone called Phoenixin-14, which is thought to influence appetite, before and after the procedure. The goal was to s…