Diet study reveals why some lose more weight than others

NCT ID NCT07012226

Completed Knowledge-focused Sponsor: Shahid Beheshti University of Medical Sciences Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This completed study looked at how a low-calorie diet changes the activity of certain genes in white blood cells and affects heart health markers in 60 people with high triglycerides and overweight. Researchers compared those who lost more weight to those who lost less, to understand differences in gene expression and blood fat levels. The goal was to learn more about why some people respond better to diet changes.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Low-calorie diet
What this could lead to: If successful, this research could help explain why some people respond better to calorie-restricted diets than others, potentially leading to more personalized dietary advice for managing high triglycerides.
What could go wrong: This is a small, completed observational study, not a treatment trial. The findings are exploratory and may not lead to direct clinical changes or apply to everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

hypertriglyceridemia Obesity obesity disorder Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HYPERTRIGLYCERIDAEMIA OBESITY AND OVERWEIGHT

Contacts and locations

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Locations

Nutrition Clinic located in the Faculty of Nutrition Sciences, Shahid Beheshti University of Medical Sciences

Tehran, Tehran Province, Iran

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