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Diet study reveals why some lose more weight than others

NCT ID NCT07012226

Knowledge-focused Sponsor: Shahid Beheshti University of Medical Sciences Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This completed study looked at how a low-calorie diet changes the activity of certain genes in white blood cells and affects heart health markers in 60 people with high triglycerides and overweight. Researchers compared those who lost more weight to those who lost less, to understand differences in gene expression and blood fat levels. The goal was to learn more about why some people respond better to diet changes.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Low-calorie diet
What this could lead to
If successful, this research could help explain why some people respond better to calorie-restricted diets than others, potentially leading to more personalized dietary advice for managing high triglycerides.
What could go wrong
This is a small, completed observational study, not a treatment trial. The findings are exploratory and may not lead to direct clinical changes or apply to everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

60 people

The number who actually took part.

Started

Jun 2025

Finished

Jan 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Mild to moderate hypertriglyceridemia (TG=150-500 mg/dL) * Body mass index (BMI) greater than 25 * Not using fibrates Exclusion Criteria: * Advanced chronic kidney disease patients * Patients with liver cirrhosis * Unwillingness to continue cooperating with the study * Any change in the treatment plan during the study, including changes in the type and dose of medications taken or the start of medications that affect blood lipids

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Conditions

The condition(s) this trial relates to.

hypertriglyceridemia Obesity obesity disorder Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Hypertriglyceridaemia Obesity and overweight

Contacts and locations

Locations

  • Nutrition Clinic located in the Faculty of Nutrition Sciences, Shahid Beheshti University of Medical Sciences

    Tehran, Tehran Province, Iran

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