Could a biweekly shot rival weekly Weight-Loss drugs?

NCT ID NCT06737042

Completed Disease control Sponsor: Gan and Lee Pharmaceuticals, USA Source: ClinicalTrials.gov ↗

First seen Jul 16, 2026 · Last updated Jul 17, 2026 · Updated 1 time

Summary

This study tests an experimental drug called GZR18, given as an injection every two weeks, to help people with obesity or overweight lose weight. It compares three doses of GZR18 against a placebo and an existing weekly weight-loss drug, tirzepatide. Participants do not have type 2 diabetes. The main goal is to see how much weight is lost after 36 weeks of treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: an experimental GLP-1 drug called GZR18
What this could lead to: If successful, this could offer a new, less frequent injection option for weight management in people with obesity or overweight.
What could go wrong: This is an early Phase 2 trial, so results may not confirm effectiveness or safety. Side effects common to GLP-1 drugs (nausea, vomiting) are possible.

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder Overweight Weight Loss

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OBESITY AND OVERWEIGHT

Contacts and locations

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Locations

3Sync Research - PCRS Network

Lake Worth, Florida, 33460, United States
Ark Clinical Research Ark-Fountain Valley

Fountain Valley, California, 92708, United States
Ark Clinical Research Ark-Long Beach

Long Beach, California, 90815, United States
Clever Medical Research - PCRS Network

Miami, Florida, 33126, United States
Clinedge - Central Valley Research, LLC

Modesto, California, 95350, United States
Clinvax Katy Research Center

Katy, Texas, 77493, United States
ERG - Ohio Clinical Trials

Columbus, Ohio, 43212, United States
ERG - Woodland Int'l Research Group

Little Rock, Arkansas, 72211, United States
ERG - Woodland Research Northwest

Rogers, Arkansas, 72758, United States
East Coast Institute for Research - ECIR Jacksonville (Southside)

Jacksonville, Florida, 32216, United States
East Coast Institute for Research ECIR Jacksonville (Headquarters) University

Jacksonville, Florida, 32216, United States
Elligo Clinical Research Center - Austin

Austin, Texas, 78704, United States
Endeavor Clinical Trials

San Antonio, Texas, 78229, United States
KUR Research - Trinity @ Bessemer, AL Site Network

Bessemer, Alabama, 35022, United States
KUR Research - Trinity @ Centreville Site Network

Centreville, Alabama, 35042, United States
KUR Research @ Columbia Site Network

Columbia, Maryland, 21045, United States
Populace Health, LLC - CTI Clinical Research Center

Cincinnati, Ohio, 45212, United States
Populace Health, LLC - Catalina Research Institute

Montclair, California, 91763, United States
Populace Health, LLC - Elixia SISU

Springfield, Massachusetts, 01103, United States
Populace Health, LLC - Vector Clinical Trials

Las Vegas, Nevada, 89128, United States

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