Ketone pills vs. keto diet: which lowers disease risk better?

NCT ID NCT06668168

Completed Knowledge-focused Sponsor: University of Bath Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether raising ketone levels—either through a ketogenic diet or a ketone supplement—can improve markers of obesity-related disease risk in overweight adults. Sixty-nine participants followed either a keto diet or took a ketone drink for four weeks. Researchers measured changes in blood proteins, gene activity, and other health indicators to see if ketones themselves, apart from diet, offer protective benefits.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Ketone monoester supplement and ketogenic diet
What this could lead to: If successful, this could help identify whether raising ketone levels safely reduces the risk of obesity-related diseases like heart disease or diabetes.
What could go wrong: This is a small, short-term study (69 people, 4 weeks) looking at blood markers, not actual disease outcomes. Results may not translate to long-term health benefits or apply to broader populations.

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Conditions

The condition(s) this trial relates to.

nutritional disorder Obesity obesity disorder Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NUTRITION OBESITY AND OVERWEIGHT

Contacts and locations

Locations

University of Bath

Bath, BA2 7AY, United Kingdom

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