Ketone pills vs. keto diet: which lowers disease risk better?

NCT ID NCT06668168

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether raising ketone levels—either through a ketogenic diet or a ketone supplement—can improve markers of obesity-related disease risk in overweight adults. Sixty-nine participants followed either a keto diet or took a ketone drink for four weeks. Researchers measured changes in blood proteins, gene activity, and other health indicators to see if ketones themselves, apart from diet, offer protective benefits.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Ketone monoester supplement and ketogenic diet

What this could lead to

If successful, this could help identify whether raising ketone levels safely reduces the risk of obesity-related diseases like heart disease or diabetes.

What could go wrong

This is a small, short-term study (69 people, 4 weeks) looking at blood markers, not actual disease outcomes. Results may not translate to long-term health benefits or apply to broader populations.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

nutritional disorder Obesity obesity disorder Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • University of Bath

    Bath, BA2 7AY, United Kingdom