OBESITY AND OVERWEIGHT

This study is testing a new injectable medication called efsubaglutide alfa to see if it helps adults with overweight or obesity lose weight. About 200 participants will receive either the drug or a placebo (a dummy injection) for 22 weeks to compare results. Researchers will mea…

This pilot study is testing a new smartphone app designed to help teens with obesity manage their weight. The app is based on a theory that suggests replacing unhealthy eating habits with positive coping behaviors. Researchers will enroll 38 adolescents to test the app's usabilit…

This study is testing a simple weight loss program designed specifically for college students. The program focuses on making small, manageable changes to eating habits rather than major lifestyle overhauls. Researchers want to see if offering this program through campus health ce…

This study is testing whether a daily postbiotic supplement can help overweight adults lose weight and improve their metabolic health. Researchers will compare the supplement to a placebo in 80 participants over 12 weeks. They will measure changes in weight, food cravings, blood …

This study is testing if a weekly injection called tirzepatide, which is approved for weight loss and diabetes, can also help people reduce heavy alcohol use. It will involve 42 adults who have alcohol use disorder and are overweight or obese. Participants will receive either the…

This study is testing whether a lifestyle program combining a Mediterranean diet, reduced calories, and physical activity can help middle-aged adults with metabolic syndrome lose weight and improve their heart health markers. Researchers will compare this program to standard heal…

This study is testing whether eating a daily serving of broccoli microgreens (young broccoli plants) for two weeks can help improve health in obese breast cancer survivors. Researchers want to see if this simple dietary addition is easy for people to stick to and if it can positi…

This study is testing if a medication called tirzepatide, which is approved for weight loss and diabetes, can also help reduce chronic inflammation in people living with HIV who are overweight or obese. It will involve 12 adults with well-controlled HIV who will receive weekly in…

This study compares two surgical approaches for patients needing revision weight-loss surgery. Researchers will track 200 patients to see if robotic surgery leads to fewer complications, less pain, and better recovery than traditional laparoscopic surgery. The study focuses on sa…

This study compares two training programs designed to help community health centers provide better weight management care to Medicaid patients. It will train doctors, dietitians, and other health workers at clinics across the country. The research will measure which training appr…

This study is testing whether eating fresh watermelon every day for six weeks can improve gut health, heart health, and body composition in young adults who are overweight or have obesity. Researchers will compare people eating watermelon to a group eating a different low-fat sna…

This is a first-in-human study to test the safety and effects of an experimental drug called WVE-007 in adults with overweight or obesity. The drug is given as an injection under the skin. The main goal is to see how well the body tolerates it and how it behaves in the bloodstrea…

This study aims to see if adding short daily stair climbing to regular brisk walking lowers high blood pressure more effectively than walking alone in inactive adults who are overweight and have hypertension. It will involve 450 participants split into three groups: one combining…

This study is testing a new weekly injection called MET097 to see how well it helps people with obesity or overweight lose weight and improve related health measures. It will involve about 3,500 adults who have weight-related health issues like high blood pressure or sleep apnea,…

This study is testing whether adding a sleep improvement program to standard weight management helps teens with obesity. Researchers will compare two groups: one gets standard care (diet and exercise advice), and the other gets standard care plus therapy sessions to improve sleep…

This study is testing if the medication tirzepatide can help adults with obesity and binge-eating disorder. Researchers will compare it against a placebo (inactive shot) and another active medication, lisdexamfetamine. All participants will also receive a guided self-help therapy…

This study is testing whether adding yoga to a standard diet and exercise program helps people with overweight or obesity lose more weight. Researchers will compare a program with aerobic exercise plus yoga to one with just aerobic exercise. They will also check if the yoga group…

This study is testing a personalized approach to help people with prediabetes and disabilities lose weight to prevent type 2 diabetes. It starts participants on either a high or low-carb diet, then adjusts their plan after 4 weeks if they aren't losing enough weight. The goal is …

This study compares three different support programs to help pregnant women maintain a healthy weight during pregnancy and after giving birth. Researchers want to see which approach works best at helping women return to their pre-pregnancy weight by 12 months after delivery. The …

This study is testing if a personalized diet plan works better than standard healthy eating advice to prevent type 2 diabetes. Researchers will enroll 240 overweight adults and use a computer model to group them by their metabolism and body type. One group will get a diet custom-…

This study tests a 6-month phone and video call program designed to help older adults with chronic knee or hip arthritis pain. The program coaches participants on increasing daily movement, reducing sitting time, and healthy eating to manage weight. Researchers want to see if thi…

This study is testing whether a daily 16-hour fasting window (eating only during 8 hours) helps women going through menopause—either naturally or after hormone therapy for breast cancer—lose weight, reduce menopausal symptoms, and improve overall health. Researchers will compare …

This study aims to track the long-term health of over 4,000 adults in Shanghai to understand how heart, kidney, and metabolic conditions like diabetes and high blood pressure develop and interact over time. It is a follow-up to health data collected from the same group of people …

This study aims to understand how a special type of body fat, called brown fat, changes when people lose weight through dieting. Researchers will compare a weight maintenance diet to a calorie-restricted diet in 30 young adults with obesity. They will use advanced scans and detai…

This study aims to understand how gut bacteria process food and how that process is different in young people with obesity and insulin resistance. Researchers will measure how the body breaks down fat and makes sugar after participants ingest a special carbohydrate. The goal is t…

This study aims to understand why ultra-processed foods might cause weight gain by measuring how many calories the gut absorbs from them. Researchers will compare two diets—one high and one low in ultra-processed foods—in 20 adults with obesity. They will analyze stool samples to…

This study aims to understand why some children break bones after minor falls. Researchers will compare 100 children (ages 3-15) who broke a bone to those who had a similar fall but did not break a bone. They will check blood levels of vitamin D and other bone markers, measure we…