OBESITY AND OVERWEIGHT

This study tests whether two plant extracts, Cissus quadrangularis and Dichrostachys glomerata, can help overweight and obese adults control their appetite and weight. The extracts are thought to work by boosting a natural hormone (GLP-1) that signals fullness and by blocking an …

This study is testing different combinations of diet and exercise to find the best weight loss plan for people with prediabetes who also have physical or mobility disabilities. Thirty participants will start with either a high or reduced carbohydrate diet. After four weeks, those…

This study tests an investigational drug called efsubaglutide alfa in 1,003 overweight or obese adults. Participants receive either the drug or a placebo injection to see how much weight they lose over 18 to 48 weeks. The goal is to find out if the drug is safe and effective for …

This early-stage study tests a new drug called HCR-188 in 48 overweight or obese adults to see if it is safe and how the body processes it. Participants receive either the drug or a placebo as injections. The goal is to gather initial safety data, not to treat obesity at this poi…

This study tests whether eating more plant-based foods or taking polyphenol supplements (like green tea and berry extracts) can help overweight adults lose weight and improve heart health. 99 participants will follow a calorie-restricted diet for 12 weeks, with one group eating e…

This study looks at how brown adipose tissue (brown fat) changes when young adults with obesity follow a calorie-restricted diet to lose 8-10% of their body weight. Researchers will use PET-CT scans and molecular tests to measure brown fat activity and compare it to a group maint…

This study tests whether infusing a natural hormone called LEAP2 can reduce how the brain reacts to pictures of food in people with obesity. Twenty-eight men with a BMI between 30 and 50 will receive either LEAP2 or a placebo on two separate days and undergo brain scans. The goal…