Could african plant extracts be the next Weight-Loss breakthrough?
NCT ID NCT06827002
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether two plant extracts, Cissus quadrangularis and Dichrostachys glomerata, can help overweight and obese adults control their appetite and weight. The extracts are thought to work by boosting a natural hormone (GLP-1) that signals fullness and by blocking an enzyme (DPP-4) that breaks it down. Researchers will measure changes in GLP-1 levels, DPP-4 activity, food intake, body weight, and other health markers over time.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Cissus quadrangularis extract (CQR-300®) and Dichrostachys glomerata extract (Dyglomera®)
What this could lead to
If successful, these plant extracts could offer a natural option to help manage weight and improve metabolic health by mimicking some effects of existing GLP-1 drugs.
What could go wrong
This is an early-phase trial (Phase 1/2) with only 248 participants, so results may not apply broadly. The extracts are not yet proven to work in humans, and side effects are still being studied.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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University of Yaounde 1
Yaoundé, Centre Region, 00237, Cameroon