Fasting test may unlock personalized obesity treatment

NCT ID NCT06874270

Terminated Knowledge-focused Sponsor: University Hospital Schleswig-Holstein Source: ClinicalTrials.gov ↗

First seen Jul 07, 2026 · Last updated Jul 08, 2026 · Updated 1 time

Summary

This study explores whether a 24-hour fast can identify two metabolic types in people with severe obesity: 'thrifty' (whose metabolism slows significantly) and 'spendthrift' (whose metabolism stays steady). Researchers will track weight loss during a 12-week very-low-calorie diet and a 12-week maintenance phase to see if the thrifty type loses less weight. The goal is to develop a simple test that personalizes obesity therapy based on an individual's unique metabolism.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could lead to a simple test that helps doctors choose the most effective weight loss plan for each person with severe obesity.
What could go wrong: This is a small, early-stage study with only 35 participants. The metabolic types identified may not reliably predict weight loss success in larger, more diverse groups.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Fasting morbid obesity Obesity obesity disorder Overweight Weight Loss

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OBESITY AND OVERWEIGHT

Contacts and locations

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Locations

University Hospital Schleswig-Holstein

Kiel, Schleswig-Holstein, 24105, Germany

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