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Can shedding pounds reshape the legs? a study tracks joint alignment after Weight-Loss surgery

NCT ID NCT07794566

Knowledge-focused Sponsor: Marmara University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 31, 2026 · Last updated Sep 04, 2026 · Updated 3 times

Summary

This observational study follows adults with morbid obesity who undergo bariatric surgery to see if substantial weight loss changes the alignment of their hips, knees, and ankles. Researchers measure leg alignment using standing X-rays before surgery and at 3, 6, and 12 months after. The goal is to understand how the weight-bearing system of the lower limbs responds to major weight loss, which may inform future research on joint health and arthritis.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Bariatric surgery (as part of routine care, not assigned by the study)
What this could lead to
If weight loss changes leg alignment, this could inform future treatments for joint pain and arthritis in people with obesity.
What could go wrong
This is a small observational study, so results may not apply to everyone. Bone shape may not change with weight loss, and the study does not test any treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 30 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2026

Expected to finish

Aug 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adults with morbid obesity undergoing bariatric surgery as part of routine clinical care will be prospectively enrolled and followed. Lower-extremity coronal alignment and mechanical-axis parameters will be evaluated using standardized standing full-length lower-extremity radiographs obtained before surgery and at approximately 3, 6, and 12 months after surgery. Serial measurements will be used to evaluate longitudinal changes in hip-knee-ankle alignment and related femoral, tibial, and knee joint-line parameters during postoperative weight loss.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 18 years or older. * Patients with morbid obesity who are scheduled to undergo bariatric surgery according to routine clinical indications. * Ability to stand independently for standardized weight-bearing lower-extremity radiographic assessment. * Availability of an appropriate preoperative standing full-length lower-extremity radiograph allowing assessment of the hip, knee, and ankle centers. * Planned postoperative clinical and radiographic follow-up at approximately 3, 6, and 12 months. * Ability and willingness to participate in the prospective follow-up protocol. Exclusion Criteria: * Previous lower-extremity corrective osteotomy, joint arthroplasty, or major reconstructive surgery that substantially alters mechanical alignment. * Previous fracture malunion or major skeletal deformity involving the pelvis, femur, tibia, knee, or ankle that prevents representative mechanical-axis assessment. * Neurological or neuromuscular disorders substantially affecting standing lower-extremity alignment. * Inability to obtain technically adequate standardized standing full-length lower-extremity radiographs. * Pregnancy at a time when radiographic assessment would otherwise be required. * Major lower-extremity trauma or surgery occurring during follow-up that may independently alter mechanical alignment. * Incomplete or unavailable radiographic data required for longitudinal analysis.

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Conditions

The condition(s) this trial relates to.

arthritic joint disease morbid obesity Obesity obesity disorder Weight Loss

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Arthritis Limb deformities OBESE

Contacts and locations

Locations

  • Department of Orthopaedic Surgery and Traumatology, Marmara University, Pendik Training and Research Hospital, İstanbul, Turkey

    Istanbul, Pendik, 34899, Turkey (Türkiye)

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