New weekly shot could help shed pounds in major obesity trial

NCT ID NCT07311850

Ongoing Disease control Sponsor: Pfizer Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 24, 2026 · Updated 4 times

Summary

This large phase 3 trial is testing a new once-weekly injection called MET097 for weight loss in 3501 adults with obesity or overweight (but without diabetes). Participants will receive either the drug or a placebo for up to 84 weeks. The main goal is to see how much weight people lose after 64 weeks of treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: MET097 (a once-weekly injection that mimics a natural hormone to help with weight loss)
What this could lead to: If it works, this could offer a new, convenient once-weekly treatment option for significant and sustained weight loss in people with obesity or overweight.
What could go wrong: This is a phase 3 trial, but results are not yet known. Weight loss may be modest for some, and side effects like nausea or rare thyroid tumors are possible. It is not a cure for obesity.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OBESITY AND OVERWEIGHT

Contacts and locations

Locations

Advanced Clinical Research

Miami, Florida, 33156, United States
Agentura science pro s.r.o.

Olomouc, 77900, Czechia
Alliance Research Institute

Canoga Park, California, 91304, United States
AmBeNet GmbH

Leipzig, 4107, Germany
Ashfields Primary Care Center

Sandbach, Cheshire, CW11 1EQ, United Kingdom
Bodyline Medical Clinic Warrington Civia Health

Paddington, WA1 3TZ, United Kingdom
Bodyline Medical Clinic, Crosby Civia Health

Liverpool, L22 4QQ, United Kingdom
Bodyline Medical Clinic, St Helens Civia Health

St Helens, WA9 1AF, United Kingdom
Bodyline Medical Clinic, Stoke-on-Trent Civia Health

Stoke-on-Trent, ST1 5TL, United Kingdom
CCR Ostrava

Ostrava, 702 00, Czechia
CDG Studienambulanz Hartard

Munich, Bavaria, 80809, Germany
Cardio D&R Košice

Košice, 040 22, Slovakia
Cedar Health Research

Dallas, Texas, 75251, United States
CenExcel Rocky Mountain Clinical Research, LLC

Englewood, Colorado, 80113, United States
CenExel CBH Health

Gaithersburg, Maryland, 20877, United States
CenExel FCR - ForCare Clinical Research

Tampa, Florida, 33613, United States
CenExel iResearch, LLC

Savannah, Georgia, 31405, United States
Centricity Research Etobicoke Endocrinology

Etobicoke, Ontario, M9R 4E1, Canada
Centricity Research Mirabel Multispecialty (Centricity Research)

Mirabel, Quebec, J7J 2K8, Canada
Centru Medical "GRANDMED"

Oradea, 410032, Romania
Centrul Medical Mediab - Mediab Srl

Târgu Mureş, 540142, Romania
Centrum Badan Klinicznych PI-House Sp. z o.o.

Gdansk, 80-546, Poland
Centrum Medyczne Pratia Gdynia

Gdynia, 81-338, Poland
Centrum Medyczne Pratia Katowice

Katowice, 40-081, Poland
Centrum Terapii Współczesnej J.M. Jasnorzewska Spółka Komandytowo-Akcyjna

Lodz, 90-338, Poland
Centrum medyczne Pratia Bydgoszcz

Bydgoszcz, 85-796, Poland
Civia Health Goodlettsville

Goodlettsville, Tennessee, 37072, United States
Civia Health Memphis

Memphis, Tennessee, 38117, United States
Civia Health Nashville

La Vergne, Tennessee, 37086, United States
Civia Health Sunderland

Hendon, CITY of Sunderland, SR1 1PB, United Kingdom
Civia Health_Boots Birmingham

Birmingham, B4 7TA, United Kingdom
Civia Health_Boots Nottingham

Nottingham, NG1 3QS,, United Kingdom
Clifton Medical Centre

Rotherham, S651DA, United Kingdom
Clinical Innovations, Inc dba CITrials

Riverside, California, 92506, United States
Clinical Research Professionals

Chesterfield, Missouri, 63005, United States
Collaborative Neuroscience Research, LLC

Garden Grove, California, 92845, United States
DIABEDA s.r.o.

Bratislava, 831 06, Slovakia
Dallas Clinical Research Center (Pillar Clinical Research)

Richardson, Texas, 75080, United States
DelRicht Research

Atlanta, Georgia, 30329, United States
Diabetespraxis Dr. Braun

Berlin, 13187, Germany
Diabeteszentrum Hamburg-West

Hamburg, 22607, Germany
Diagnostic Consultative Center Aleksandrovska

Sofia, 1431, Bulgaria
ETG Siedlce

Siedlce, 08-110, Poland
Ecg Médica S.L.

Valencia, 46015, Spain
Edumed s.r.o.

Náchod, 54701, Czechia
Ekamed Sp. z o. o.

Lublin, 20-718, Poland
Etg Warszawa

Warsaw, 02-677, Poland
Eximia EquiHealth Research

Durham, North Carolina, 27704, United States
Fakultní nemocnice Královské Vinohrady

Prague, 100 34, Czechia
Forum Austin (Civia Health)

Austin, Texas, 78758, United States
Forum Health Cary

Cary, North Carolina, 27511, United States
Fundatia Dr Victor Babes

Bucharest, 30303, Romania
Future Medical Research (Civia Health)

Longwood, Florida, 32750, United States
FutureMeds Berlin

Berlin, 10629, Germany
FutureMeds Birmingham

Birmingham, B21 9RY, United Kingdom
FutureMeds Frankfurt/Offenbach

Offenbach, 63065, Germany
FutureMeds Gdynia

Gdynia, 81-384, Poland
FutureMeds Glasgow McCafferty House

Glasgow, Scotland, G20 7BE, United Kingdom
FutureMeds Krakow

Krakow, 31-501, Poland
FutureMeds Liverpool

Bromborough, CH62 6EE, United Kingdom
FutureMeds Lodz

Lodz, 91-393, Poland
FutureMeds London

London, NW10 2PB, United Kingdom
FutureMeds Newcastle upon Tyne

Newcastle upon Tyne, NE6 1SG, United Kingdom
FutureMeds Olsztyn

Olsztyn, 10-165, Poland
FutureMeds Teesside

Stockton-on-Tees, TS19 8PE, United Kingdom
FutureMeds Warszawa Centrum

Warsaw, 00-215, Poland
FutureMeds Warszawa Targowek

Warsaw, 03-291, Poland
FutureMeds Wroclaw

Wroclaw, 53-673, Poland
Futuremeds S.R.L., Brasov

Brasov, 500388, Romania
Futuremeds S.R.L., Craiova

Criaova, 200115, Romania
Futuremeds S.R.L., Galati

Galati, 800183, Romania
Futuremeds Spain Cadiz

Chiclana de la Frontera, 11139, Spain
Futuremeds Spain Madrid

Madrid, 28003, Spain
Futuremeds Spain Sevilla

Seville, 41012, Spain
GLRI El Paso Research

El Paso, Texas, 79936, United States
Gemeinschaftspraxis Dres. H.Kittner und K.Hartig

Naunhof, 04683, Germany
Hassman Research Institute

Marlton, New Jersey, 08053, United States
Headlands Research

Scottsdale, Arizona, 85260, United States
Hightech Medical Services S.R.L (Centrul pentru Studiul Metabolismului)

Bucharest, 011053, Romania
Hospital Universitario Virgen de la Victoria

Málaga, Málaga, 29010, Spain
Hospital Virgen del Camino

Sanlúcar de Barrameda, 11540, Spain
Hospital Vithas Sevilla

Castilleja de la Cuesta, 41950, Spain
IRMED

Piotrkow Trybunalski, 97-300, Poland
Institutul Clinic Fundeni

Bucharest, 022328, Romania
Institutul National de Endocrinologie "C.I. Parhon"

Bucharest, 011863, Romania
Instytut Diabetologii.sp.z.o.o.

Warsaw, 02-117, Poland
JAL s.r.o

Trnava, 91701, Slovakia
Kiltearn Medical Centre

Nantwich, CW5 5NX, United Kingdom
Klinische Forschung Berlin-Mitte GmbH

Berlin, 10117, Germany
Klinische Forschung Dresden GmbH / Pratia

Dresden, 01069, Germany
Klinische Forschung Hamburg GmbH / Pratia

Hamburg, 20253, Germany
Klinische Forschung Karlsruhe GmbH

Karlsruhe, 76137, Germany
LMC Diabetes & Endocrinology - Bayview (Centricity Research Toronto LMC Multispecialty)

Toronto, Ontario, M4G 3E8, Canada
MC Nevromedics Ltd.

Veliko Tarnovo, 5005, Bulgaria
MEDI-DIA s.r.o

Sabinov, 083 01, Slovakia
MHAT Botevgrad

Botevgrad, 2140, Bulgaria
MHAT Sveta Karidad EAD

Plovdiv, 4004, Bulgaria
Medical Center - Clinic Nova EOOD

Varna, 9020, Bulgaria
Medical Center 4Life EOOD

Burgas, 8018, Bulgaria
Medical Center Berbatov

Yambol, 8600, Bulgaria
Medical Center Futuremeds EOOD

Plovdiv, 4000, Bulgaria
Medical Center Hera EOOD

Sofia, 1510, Bulgaria
Medical Center New Polyclinic Gabrovo Ltd.

Gabrovo, 5300, Bulgaria
Medical Center Zdrave 1

Kozloduy, 3320, Bulgaria
Medical Centre Pratia Clinic EOOD

Varna, 9020, Bulgaria
Medical group Kosice s.r.o.

Košice, 04001, Slovakia
Medicome Sp. z o.o. Oświęcimskie Centrum Badań Klinicznych

Oświęcim, 32-600, Poland
Medislim GmbH

Weinheim, 69469, Germany
Medispektrum s.r.o.

Bratislava, 85101, Slovakia
Medivasa s.r.o

Žilina, 010 01, Slovakia
Medizentrum Essen Borbeck

Essen, 45355, Germany
Metabolica Sp. z o.o., NZOZ METABOLICA Ośrodek Badań Klinicznych

Tarnów, 33-100, Poland
Minimed S.R.L.

Bacau, 600237, Romania
Multiprofile Hospital for Active Treatment Dobrich AD (MHAT Dobrich AD)

Dobrich, 9300, Bulgaria
NZOZ Centrum Medyczne KERmed

Bydgoszcz, 85-231, Poland
Nemocnice Jihlava

Jihlava, 58601, Czechia
Nuevas Tecnologías en Diabetes y Endocrinología S.L.

Seville, 41003, Spain
Oviedo Medical Research

Oviedo, Florida, 32765, United States
Palmetto Internal Medicine

Mauldin, South Carolina, 29662, United States
Pantheon Clinical Research

Bountiful, Utah, 84010, United States
Panthera Biopartners Limited - Enfield

Enfield, EN3 4GS, United Kingdom
Panthera Biopartners Limited - Glasgow

Glasgow, G51 4TY, United Kingdom
Panthera Biopartners Limited - Preston

Preston, PR2 9QB, United Kingdom
Panthera Biopartners Limited - Rochdale

Rochdale, OL11 4AU, United Kingdom
Panthera Biopartners Limited - Sheffield

Sheffield, S2 5FX, United Kingdom
Panthera Biopartners Limited - York

York, YO24 4LJ, United Kingdom
Peninsula Headlands LLC

Rolling Hills, California, 90274, United States
Poliklinika Váš Lekár

Bratislava - Ružinov, 91109, Slovakia
Praktyka Lekarska Ewa Krzyzagorska

Poznan, 61-655, Poland
Pratia Brno,s.r.o

Brno, 60200, Czechia
Pratia Chojnice

Chojnice, 89-600, Poland
Pratia Pardubice

Pardubice, 53002, Czechia
Praxis Reinfeld Mitte

Holstein, 23858, Germany
Praxis am Markt - Dr. Bernd Becker

Essen, 45355, Germany
Prevencia - 2000 - Medical Center for Prehospital Medical Care OOD

Stara Zagora, 6000, Bulgaria
Primary clinical Research

Papillion, Nebraska, 68046, United States
Quality Clinical Research Inc

Omaha, Nebraska, 68114, United States
ResTrial s.r.o.

Prague, 18100, Czechia
Research Centers of America

Hollywood, Florida, 33024, United States
Sahana Optometry PLLC dba Family Eye Wellness

Holly Springs, North Carolina, 27540, United States
Santa Familia PTG Lodz

Lodz, Łódź Voivodeship, 90-302, Poland
Sc Gensan Srl/Policlinica Astra

Sibiu, 550371, Romania
Southmead Hospital

Bristol, BS10 5NB, United Kingdom
Studienzentrum FMZ Radowsky

Leipzig, Saxony, 4179, Germany
Summit Headlands LLC

Portland, Oregon, 97210, United States
Synexus Glasgow Clinical Research Centre

Bellshill, ML4 3NJ, United Kingdom
Synexus Manchester Clinical Research Centre

Manchester, M15 6SE, United Kingdom
Synexus Midlands Clinical Research Centre

Birmingham, B15 2SQ, United Kingdom
Synexus Polska Sp z o.o.

Gdansk, 80-382, Poland
Synexus Polska Sp. Z O.O. Oddzial W Katowicach

Katowice, 40-040, Poland
Synexus Polska Sp. z o.o. Oddzial w Gdyni

Gdynia, 81-537, Poland
Synexus Polska Sp. z o.o., Oddzial w Czestochowie

Częstochowa, 42-202, Poland
Synexus Polska Sp. z o.o., Oddzial w Lodzi

Lodz, 90-127, Poland
Synexus Polska Sp. z o.o., Oddzial w Warszawie

Warsaw, 02-672, Poland
Synexus Polska Sp. z o.o., Oddział w Poznaniu

Poznan, 60-702, Poland
Synexus Polska Sp. z o.o., Oddział we Wrocławiu

Wroclaw, 50-381, Poland
Synexus/Trialmed Prague

Prague, 120 00, Czechia
TMA Headlands LLC

Wilmington, North Carolina, 28403, United States
TMA Headlands LLC - Wilmington

Wilmington, North Carolina, 28403, United States
Tatratrial s.r.o.

Rožňava, 048 01, Slovakia
The Wharton Medical Clinic Clinical Trials Inc

Hamilton, Ontario, L8L 5G8, Canada
Trialmed CRS

Piotrkow Trybunalski, 97-300, Poland
Tribe Clinical Research LLC. - Spartanburg

Spartanburg, South Carolina, 29301, United States
Tribe Clinical Research LLC.- Greenville

Greenville, South Carolina, 29607, United States
Upgrade Performance Institute

Elkhorn, Nebraska, 68022, United States
Velocity Clinical Research Germany

Berlin, 10787, Germany
Zdrowie Osteo Medic sc L i A Racewicz, A i J Supronik

Bialystok, 15-351, Poland
Zentrum für klinische Forschung

Cologne, 51069, Germany
Zentrum für klinische Forschung Allgäu-Oberschwaben

Wangen, 88239, Germany
Zentrum für klinische Studien Bad Homburg

Bad Homburg, 61348, Germany

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