WEIGHT LOSS

This study tests whether a gentle electrical current applied to a brain area involved in fullness can reduce food intake and promote weight loss. Over 4 weeks, 148 obese adults will receive either real or fake stimulation while following a reduced-calorie diet. The goal is to see…

This study tests a temporary stomach balloon called Orbera365 to help people with obesity lose weight. About 144 adults with a BMI between 28 and 50 who have not succeeded with diet and exercise will get the balloon. The main goal is to see if at least 5% of body weight is lost a…

This study tests whether a minimally invasive procedure called endoscopic sleeve gastroplasty (ESG), which reduces stomach size by 70%, can help reverse fatty liver disease (MASH) in people with obesity. Researchers will compare ESG plus lifestyle changes to lifestyle changes alo…

This study compares weight loss using semaglutide (a drug) versus a calorie-restricted diet in 100 people with obesity and heart failure with reduced ejection fraction. The goal is to see which approach better improves peak oxygen uptake, a measure of exercise capacity, after 52 …

This study tests a procedure called transoral outlet reduction (TORe) combined with intensive lifestyle changes for people who have regained weight after gastric bypass surgery. About 108 participants will be randomly assigned to either receive the TORe procedure plus lifestyle c…

This study tests a personalized program to help people who have lost weight keep it off. About 30 adults who lost at least 7% of their body weight in the past 6 months will receive weekly texts, surveys, and possibly health coaching over 26 weeks. The goal is to see if this appro…

This small pilot study at Yale tests whether semaglutide (a drug used for diabetes and weight loss) can help people who have had bariatric surgery and now struggle with alcohol use disorder. Ten adults will take the drug for three months and be followed for three more months to s…

This study tests a coordinated weight loss program where parents and children work together to eat healthier, be more active, and support each other. About 90 families will join, with parents attending their own program while kids take part in a pediatric weight management clinic…

This study tests whether adding sleep health coaching to a diet and exercise program can improve heart health, especially blood pressure. About 150 adults with high blood pressure from underserved NYC neighborhoods will take part. The program includes sleep education, a Fitbit tr…

This study tests whether a strict low-carbohydrate diet combined with lifestyle guidance can help obese men (BMI 30+) lose weight and improve their fertility. Researchers will track weight, semen quality, and reproductive outcomes in 98 men aged 22-40. The goal is to find a non-d…

This study tests whether adding an essential amino acid supplement (EAA-AC) to a low-calorie, low-protein diet helps people with severe obesity lose weight while keeping muscle mass. Sixty participants aged 45-65 with a BMI over 35 will be randomly assigned to receive either the …

This study compares two ways of doing aerobic exercise: before eating (fasted) versus after eating (fed). Over 16 weeks, 40 adults with obesity will follow a supervised exercise program. Researchers will measure changes in body fat, blood fats, blood pressure, and appetite hormon…

This study looks at whether adding protein supplements to a weight-loss plan (diet plus the drug semaglutide) helps overweight or obese adults lose more weight, keep muscle, and avoid gaining weight back. About 140 people will take part in a 3-month program and be followed for 6 …

This study tests whether a probiotic (Lactobacillus paracasei) or the drug semaglutide can help overweight or obese adults lose weight and improve metabolism. Over 12 weeks, 140 participants will follow a reduced-calorie diet and lifestyle program while taking one of these or a p…

This study tests whether matching specific weight-loss medications (Wegovy, Contrave, or Qsymia) to a person's obesity type (e.g., 'hungry brain' or 'emotional hunger') helps people with bipolar disorder lose weight safely. One hundred adults with bipolar or schizoaffective disor…

This study tests whether a daily postbiotic gummy, combined with healthy eating advice, can help overweight or obese adults lose body fat and improve metabolic health. Over 12 weeks, 114 participants will be randomly assigned to receive either the postbiotic or a placebo gummy, a…

This study tests a drug called efsubaglutide alfa to help people who are still obese six months after weight-loss surgery lose more weight. About 60 adults aged 18 to 55 with a BMI of 28 or higher will take the drug or a placebo. The main goal is to see how much weight they lose …

This study tests whether a 6-month lifestyle program (diet, exercise, coaching) or the drug metformin is better for weight loss in mothers who recently had gestational diabetes. Sixty women who gave birth in the last year will join. Participants track their activity and weight, a…

This study aims to find the best combination of strategies to help people maintain weight loss after losing at least 5% of their body weight. Over 500 participants will first lose weight through a 16-week program, then be assigned to different packages of four methods: eating few…

This study looks at whether time-restricted eating (eating only during a set window each day) can help adults who have recently lost weight keep it off and avoid regaining fat. About 110 adults aged 25-65 who lost at least 5% of their body weight in the last 3 months will be rand…

This study tests whether combining lifestyle coaching with a smartphone app helps young adults (ages 18-40) who are overweight or obese lose weight. All 140 participants will receive diet and exercise goals and coaching. Researchers will measure weight change after 6 months to se…

This study tests whether virtual dietary counseling helps active duty women lose weight after their first pregnancy and meet military fitness standards. Seventy-four women will be randomly assigned to receive either intensive diet coaching or standard postpartum care for one year…

This study follows 234 people who regained weight after a sleeve gastrectomy and are now getting a revision surgery. The goal is to compare three procedures—SADI-S, RYGB, and OAGB—to see which leads to the most weight loss, fewest complications, and best nutritional outcomes. Par…

This study tests a family-centered program to help Hispanic families lose weight and prevent obesity. About 1,319 parents and their children ages 8-12 will take part. The program uses text messages and family support to encourage healthy eating and activity.

This pilot study tests a smartphone app called BrainWeighve that helps teens aged 14-21 with obesity lose weight by replacing overeating with healthier coping behaviors. The study enrolls 38 participants to test the app's feasibility and satisfaction over 4 months. It is an early…

This study tests whether megestrol acetate, a drug that boosts appetite, can help patients with locally advanced colorectal cancer avoid weight loss during chemotherapy. About 60 adults will receive either the drug or a placebo alongside their standard treatment. The goal is to s…

This study looks at people who had an endoscopic sleeve gastroplasty (ESG) at least 5 years ago to see if they kept the weight off. Researchers will measure total body weight loss at the 5-year mark. The goal is to understand the long-term success of this weight-loss procedure.

This study investigates how exercise affects the structure and function of fat tissue in adults aged 18-40 with obesity or metabolic syndrome. Participants are randomly assigned to either an exercise program or a sedentary control group. All undergo a 10% weight loss phase, then …

This early-stage study looks at how the body processes HRS9531 injection in people with mild or moderate liver issues compared to those with healthy livers. Researchers will measure drug levels and check for side effects in 24 participants. The goal is to understand if liver func…

This study looks at whether eating peanuts every day can improve bone health, metabolism, and physical function in overweight or obese adults aged 50-75 during a 6-month weight loss program. Participants will be randomly assigned to eat either a daily peanut snack or a nut-free s…

This study looks back at medical records of 150 adults aged 18-60 who took GLP-1 drugs like semaglutide for weight loss. Researchers want to understand how these drugs change taste perception, food preferences, and eating behaviors. The goal is to learn more about why these medic…

This study looks at tiny particles released from fat cells, called extracellular vesicles, and how they relate to blood vessel function in people with obesity. Researchers will compare normal-weight and obese adults, then have obese participants follow a 12-week weight loss diet.…

This study collects information from medical records and patient visits to see how well endoscopic bariatric therapies (EBTs) work for weight loss and if they are safe. It includes adults who have had or plan to have an EBT within six months. The goal is to track weight changes a…

This study looks at what happens inside your fat tissue when you lose weight with or without exercise. 68 adults with obesity will lose 10% of their body weight through diet, with some also doing moderate exercise. Researchers will measure insulin sensitivity, fat breakdown, and …

This study looks at how tirzepatide, a weight-loss drug, affects muscle mass and strength in adults aged 50 and older with obesity. Researchers want to know if losing weight with this drug also causes harmful muscle loss that could lead to frailty. Twenty participants will take t…

This study looks at how quickly losing weight through dehydration (using a sauna) affects combat athletes' sleep quality, thinking skills, and leg strength. Twelve athletes with prior weight-cutting experience will be monitored before and after losing 3% of their body weight. The…

This study looks at how losing weight and improving diabetes after bariatric surgery changes brain function and thinking skills. Researchers will also test if a non-invasive nerve stimulation device, started 30 days after surgery, can further improve brain health. The study invol…

This study explores whether changing gut bacteria with antibiotics can help people keep weight off after losing at least 10% of their body weight. 200 adults with a BMI between 28 and 35 will take either antibiotics or a placebo for 10 days. Researchers will track weight, microbi…

This study explores whether intravenous (IV) fluids given to mothers during labor are linked to how much weight formula-fed newborns lose in their first two days. Researchers will review medical records of 200 mothers and their full-term babies at a French hospital. The goal is t…

This study looks at how GLP-1 medications (like Ozempic or Wegovy) affect people's attitudes toward food and what they choose to eat. Researchers will use a virtual reality buffet to measure food selections before starting the medication and again after three months. The goal is …