WEIGHT LOSS

This study tests a device called Orbera365, a balloon placed in the stomach to help people with obesity lose weight. About 144 adults with a BMI between 28 and 50 who have not succeeded with diet and exercise will take part. The balloon is inserted without surgery and left for up…

This study will test if a procedure called endoscopic sleeve gastroplasty (ESG) using the OverStitch NXT system is safe and helps obese adults lose weight. About 136 Asian participants with a BMI of 27.5 or higher will be enrolled. The main goal is to see if at least 5% of total …

This study tests a 10-week behavioral program to help people maintain weight loss after stopping GLP-1 or other anti-obesity medications. 64 adults who lost at least 15% of their body weight on these drugs will be followed for 6 months. The program includes meal plans, gym member…

This study tests whether giving a daily probiotic supplement to 180 healthy, full-term babies born by C-section can help them gain weight, have fewer digestive problems like colic and spitting up, and develop a healthier gut. The babies will receive either one of two probiotic bl…

This study aims to find the best combination of four dietary strategies—limiting high-calorie foods, eating within a set time window, increasing protein, and increasing fiber—for weight loss in adults with overweight or obesity. Over 12 weeks, 208 participants will track their we…

This study in Côte d'Ivoire tests whether giving mothers a cash reward for breastfeeding until their child is 24 months old increases breastfeeding rates and improves child and maternal health. About 1040 mothers will either receive the cash incentive or just educational material…

This study aims to adapt a community weight loss program called TOPS for breast cancer survivors. Researchers will first hold focus groups with survivors to review and improve program materials, then test the tailored program with 25 women. The goal is to see if the program helps…

This study looks at how two common weight loss methods—GLP-1 medications and bariatric surgery—change pelvic floor symptoms like bladder leaks, urgency, and prolapse in women. About 200 women aged 18-89 with a BMI of 30 or higher will join. The goal is to help doctors choose the …

This study will use ultrasound to take pictures of the stomach in 10 patients who are having weight-loss surgery. The goal is to learn how the stomach looks before and after the operation. Patients will be asleep during the imaging, so there is little discomfort.

This early-stage study looks at how the body processes HRS9531, a drug for diabetes and weight loss, in people with mild or moderate liver issues compared to those with healthy livers. About 24 adults will receive a single dose to measure drug levels and check for side effects. T…

This study explores whether daytime fasting during Ramadan, alone or with moderate aerobic exercise, can help overweight adults lose body fat and improve heart health. About 30 participants will be randomly assigned to fasting only or fasting plus supervised exercise. Measurement…