Can a High-Protein diet and weight training prevent muscle loss while on Weight-Loss drugs?
NCT ID NCT07700030
First seen Jul 13, 2026 · Last updated Jul 14, 2026 · Updated 1 time
Summary
This study investigates whether adding a high-protein diet and supervised resistance training to the weight-loss medication tirzepatide helps preserve muscle mass better than a high-protein diet alone. Adults aged 30–60 with a BMI between 27 and 37 who are about to start tirzepatide will be randomly assigned to one of two groups. The goal is to see if the combination approach can reduce muscle loss and improve strength during weight loss.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- high-protein diet and resistance training
- What this could lead to
- If successful, this could show that combining a high-protein diet with resistance training helps people lose fat while keeping more muscle during weight-loss medication use.
- What could go wrong
- This is a small, early-stage study with only 32 participants, so results may not apply widely. The diet and exercise program require strict adherence, which may be challenging for some.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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NYU Langone Health
New York, New York, 10016, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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