WEIGHT LOSS

This small pilot study tested the safety of a swallowable intra-gastric balloon (IGBalloon) for weight loss in 5 people with obesity. Participants swallowed up to 5 balloons over 8 weeks, with regular check-ups including blood tests and endoscopies. The study also looked at weigh…

This study followed 543 adults aged 18-60 who had bariatric surgery at four hospitals in Norway. Each hospital used a different surgical method, allowing researchers to compare how well each approach helped with weight loss and type 2 diabetes remission. The goal was to find whic…

This study tested a salmon protein supplement called ProGo in 14 healthy overweight adults. Participants took either ProGo or whey protein daily for 8 weeks. Researchers measured changes in blood health, body fat, and self-reported hair, skin, and nail quality. The goal was to se…

This study looked at whether eating only during a 10-hour window each day and doing high-intensity interval training three times a week can improve health in people with metabolic syndrome. Two hundred adults took part for 16 weeks. Researchers measured changes in metabolic syndr…

This study looked at whether a 12-week intensive lifestyle program focused on weight loss and diabetes control could improve diabetic peripheral neuropathy, a common nerve complication. Fifty adults with diabetes and a BMI between 30 and 45 took part. The program included diet, e…

This study tested a 16-week online program called Sleep GOALS to help new mothers lose weight by improving their sleep, diet, and physical activity. Forty postpartum women with a BMI over 25 and poor sleep were enrolled. The program provided strategies and self-monitoring tools t…

This study tested a 'digi-physical' approach for families with children or teens living with obesity. Participants either received standard in-person care or a mix of digital tools (an app for tracking health and chatting with caregivers) plus fewer in-person visits. The goal was…

This completed phase 4 trial tested whether a rapid weight loss program using semaglutide (Ozempic/Wegovy) plus a very low calorie diet can help people with idiopathic intracranial hypertension (IIH), a condition where high pressure in the skull causes headaches and vision proble…

This study looked at whether liraglutide, a drug used for diabetes and weight loss, can help people who are still obese 6 months after metabolic surgery lose more weight. 100 participants received liraglutide injections for 24 weeks along with diet and exercise guidance. The goal…

This study looked at whether weight-loss surgery (vertical sleeve gastrectomy) can improve kidney, heart, and pancreas function in teens aged 12-21 with type 2 diabetes and obesity. Researchers measured blood flow to the kidneys, kidney filtering ability, and insulin production b…

This study looked at whether giving people personalized lifestyle advice based on their genetic test results (SNP testing) helps them lose more weight than standard advice. Overweight or obese Korean adults were followed for about 17 months. The goal was to see if tailoring diet …

This study tested a 24-week program that combines WeightWatchers behavioral coaching with prescription GLP-1 medications like Wegovy, Mounjaro, or Zepbound. 180 adults with obesity or weight-related conditions participated. Researchers measured weight loss and related outcomes at…

This study tested a 12-month healthy lifestyle program for 112 youth aged 8-18 with serious emotional disturbance who were overweight or obese. Participants worked with a health coach to improve diet and physical activity, with parents involved. The goal was to see if this approa…

This study compares two surgeries—One Anastomosis Gastric Bypass and Duodenojejunostomy—for treating Superior Mesenteric Artery Syndrome (SMAS), a rare condition where the duodenum is compressed, causing severe nausea, vomiting, and weight loss. Twenty participants were randomly …

This completed study compared two popular diets for weight loss in 120 obese adults. One group followed intermittent fasting (eating only between 1 PM and 9 PM), while the other followed a traditional Mediterranean diet. Both diets cut about 500 calories per day. The goal was to …

This study tested whether an online family skills training program is practical and well-liked for Black adults trying to lose weight. 21 participants joined with a family member. The program focused on healthy eating and activity habits.

This study tested a new weight loss program called Med-South, which adapts the Mediterranean diet for Southern tastes, against the popular WW (Weight Watchers) program. Over 360 adults with obesity participated for 2 years, with researchers tracking weight loss, blood markers, an…

This study tested whether a virtual reality (VR) diet program is a practical way to help people with fatty liver disease lose weight. Twenty adults with fatty liver were randomly assigned to receive diet counseling either in person or through a VR headset. The VR program, called …

This study tested whether lifestyle coaching delivered through a patient portal helps adults maintain weight loss. 269 participants who had already lost at least 5% of their body weight were randomly assigned to receive either coaching plus tracking tools or tracking tools alone …

This study tested three different weight loss strategies in 110 adults with chronic spinal cord injury who were overweight. The strategies included portion-controlled meals, enhanced self-monitoring with technology, and a tailored lifestyle program called GLB-SCI. The goal was to…

This study tested an experimental daily pill, VK2735, to help adults with obesity or overweight (plus a weight-related health issue) lose weight. About 280 participants took either the pill or a placebo for 13 weeks. The main goal was to see how much weight they lost and if the p…

This study tested whether fasting for at least 14 hours each night could help overweight people with early blood cancer conditions (MGUS, smoldering myeloma) lose weight and possibly lower their cancer risk. Twenty-three participants were randomly assigned to either the fasting p…

This study looked at whether a three-month diet and exercise program before IVF could improve live birth rates in overweight and obese women. 197 women were randomly assigned to either the weight loss group or a control group. The goal was to see if losing weight beforehand leads…

This completed study looked at three ways to help people aged 65 and older with type 2 diabetes improve their physical and metabolic health. One group did home-based circuit resistance training, another followed a plant-based Mediterranean diet, and the third took the diabetes dr…

This study tested whether using social networks could help Hispanic and Somali immigrants in Minnesota lose weight and lower heart disease risk. About 475 people took part, and researchers tracked weight, waist size, and heart health over 6 to 12 months. The goal was to see if fr…

This study tested whether a fully automated digital program could help people with prediabetes lose weight and lower their blood sugar as effectively as a program led by a human coach. About 368 adults with prediabetes and overweight took part. The goal was to see which approach …

This study tested whether a mindfulness-based training program could help adults who had lost weight keep it off. 48 participants, including those who had bariatric surgery or lost weight through medical or lifestyle programs, took part. The goal was to see if focusing on eating …

This study tested a program where community health workers led group sessions to help South Asian adults with pre-diabetes lose weight. Nearly 1,000 participants took part. The goal was to see if this approach could help them lose at least 5% of their body weight and reduce their…

This completed study tested a daily supplement combining a postbiotic and a prebiotic in 20 adults aged 18-65 with a BMI between 25 and 30. Participants took the supplement for 60 days and reported changes in appetite, cravings, energy, mood, and quality of life through a mobile …

This study tested whether following a very low calorie diet before bariatric surgery helps patients lose more weight and feel more satisfied. 85 adults who were eligible for surgery took part. Researchers compared the very low calorie diet to standard dietary advice.

This study tested whether combining two types of dermal fillers—Sculptra and Restylane—can improve cheek volume, wrinkles, and skin quality in 41 adults with moderate-to-severe cheek aging. Participants had a history of weight loss or were taking GLP-1 medications. They received …

This study looked at whether adding mindfulness and acceptance skills to standard weight loss counseling helps people lose more weight. 276 adults with overweight or obesity participated. Researchers tested three specific skills: awareness, acceptance, and values clarity, to see …

This study tested whether a mobile app (Care4Today®) helps people with severe obesity lose weight before gastric bypass surgery. 142 adults used either the app or standard care. The goal was to see if the app leads to more weight loss and better patient knowledge and satisfaction…

This completed pilot trial tested whether adding a low-carb, high-protein diet (like Atkins) helps people lose more weight while taking the injectable drug semaglutide. 60 overweight or obese adults were randomly assigned to follow either a low-carb or low-fat diet for 3 months. …

This study looked at whether eating high-fiber snack bars could reduce stomach symptoms like nausea, bloating, and gas in adults taking GLP-1 weight-loss medications (such as Ozempic or Mounjaro). Fifty participants tried three different fiber bars and one low-fiber bar over seve…

This pilot study tested whether giving ondansetron (Zofran) before drinking bowel-cleansing liquid helps children have a cleaner colon and feel less sick. 41 kids aged 2 to 20 took either ondansetron or a placebo before their colonoscopy. The study measured bowel cleanliness and …

This pilot study tested whether shared medical visits (group doctor appointments) plus cooking classes help people manage their weight. 43 adults with obesity from a weight management center were randomly assigned to either group visits with cooking classes or online modules abou…

This study looked at why many families leave pediatric weight management programs early. Researchers used data from over 1,200 children and their parents to build a tool that predicts dropout. The goal is to help programs keep families engaged and improve long-term health outcome…

This study collects and stores medical data from adults who had robotic bariatric surgery between 2018 and 2019. The goal is to build a database that helps doctors understand how well this type of surgery works for weight loss and related health issues. By analyzing real-world ou…

This study looked at how often people eat and whether it affects weight loss. Researchers followed 30 overweight adults aged 18 to 65. They tracked eating habits, calories, and weight to better understand the link between meal timing and losing weight.

This study looked at how common cardiac cachexia (unintentional weight loss) is in people with advanced heart failure and how it affects their outcomes. Researchers followed about 200 patients for one year to compare survival and hospitalizations between those with and without th…

This study looked at whether adding moderate aerobic exercise during Ramadan fasting helps overweight adults lose more fat and improve heart health compared to fasting alone. Twenty-eight participants were split into two groups: one only fasted, the other fasted and exercised fiv…

This pilot study looked at how weight loss affects bone density in overweight or obese men. 44 men either followed a reduced-calorie diet to lose weight or maintained their weight for 6 months. Researchers measured changes in bone density and quality to see if weight loss has any…

This study looked at how different amounts of protein in the diet affect bone health when overweight or obese postmenopausal women lose weight. Researchers measured changes in bone density and quality, as well as diet quality. The goal was to learn, not to treat or cure any disea…

This study looked at how a short period of rapid weight loss combined with exercise changes blood cells and immune cells in nine elite male wrestlers. The wrestlers lost about 4.3% of their body weight over five days, and blood samples were taken before and after exercise. The go…

This study aims to understand why some people gain or lose weight more easily than others. Researchers will measure how the body's energy use changes during overeating and dieting in 83 healthy adults. Participants will stay in the hospital for 10 weeks, undergoing tests like met…

This study looked at whether eating only during a 9-hour window each day (time-restricted eating) affects bone health, weight, and gut bacteria in overweight or obese older women. 49 postmenopausal women were randomly assigned to either eat within a 9-hour window or a 12-hour win…

This study used smartphone surveys and Fitbit trackers to figure out what causes people to slip up on their diet and exercise goals during a weight loss program. About 119 adults with overweight or obesity participated in a remote behavioral weight loss program. The goal is to us…

This completed study looked at how muscle energy use differs in women with ovarian or endometrial cancer who are losing weight, depending on their body mass index (BMI). Researchers took blood samples, muscle biopsies, and fat tissue from 70 women during surgery. The goal was to …

This study looked at how stress, behavior, and social factors affect weight loss and heart health in people from disadvantaged backgrounds. 15 adults with overweight or obesity took part. Researchers measured weight, waist size, and heart health over time to understand what helps…