WEIGHT LOSS

This study tested if weight-loss surgery (vertical sleeve gastrectomy) could improve pancreas, kidney, and heart health in teens aged 12-21 with type 2 diabetes and severe obesity. Researchers measured kidney function, blood flow, and insulin production before and after surgery. …

This study tested an experimental daily pill called VK2735 for weight loss in 280 adults who are obese or overweight with a weight-related health issue like high blood pressure. Participants took the pill or a placebo for 13 weeks to see how much weight they lost and if it was sa…

This study involved 100 adults who were still obese 6 months after weight-loss surgery. Researchers compared starting the drug liraglutide early versus later to see which timing leads to greater weight loss and health improvements. The goal is to find the best way to help patient…

This study tested whether a mobile app (Care4Today®) helps people with severe obesity lose more weight before gastric bypass surgery compared to standard care. 142 adults aged 18-65 who qualified for surgery used the app or followed the usual pre-surgery plan. The goal was to see…

This study tested whether a weight-loss drug (semaglutide) combined with a very low-calorie diet could help people with idiopathic intracranial hypertension (IIH), a condition where high pressure in the brain causes headaches and vision problems. 38 adults with newly diagnosed II…

This study looked at whether giving overweight or obese adults personalized lifestyle advice based on their genetic test results (SNP testing) helps them lose more weight than standard advice. About 53 Korean adults took part over roughly 17 months. The goal was to see if tailori…

This study tested whether adding mindfulness, acceptance, and values-clarity techniques to standard weight loss counseling helps adults with overweight or obesity lose more weight. 276 adults aged 18-70 with a BMI between 27 and 50 took part. Researchers compared different combin…

This study tested a weight maintenance program delivered through a patient portal. Adults who had already lost at least 5% of their body weight were randomly assigned to track their weight, diet, and activity with or without coaching from routine healthcare staff. The goal was to…

This study tested whether fasting for a longer period each night could help overweight or obese people with early signs of blood cancer (MGUS, smoldering multiple myeloma, or smoldering Waldenstrom macroglobulinemia) lose weight and possibly lower their cancer risk. Twenty-three …

This study looked at whether eating only during a specific window each day (time-restricted eating) combined with short, intense exercise (high-intensity interval training) can improve health markers in people with metabolic syndrome. 200 overweight or obese adults with metabolic…

This study looked at three ways to help older adults (65+) with type 2 diabetes improve their body composition and physical function: circuit resistance training (home exercises), a plant-based Mediterranean diet, or the drug empagliflozin. One hundred participants were assigned …

This study tested a 12-month healthy weight program for 112 youth aged 8-18 with serious emotional disturbance who were overweight or obese. The program included a health coach who worked with both the child and parents to improve diet and physical activity. The goal was to reduc…

This study looked at whether a program that combines WeightWatchers behavioral coaching with prescription weight-loss drugs (Wegovy, Mounjaro, or Zepbound) helps people lose weight. 180 adults with obesity or weight-related health issues took part for 24 weeks. Researchers measur…

This study tested whether an online family skills training program is practical and well-liked by Black adults trying to lose weight. 21 participants joined with a family member and attended online sessions. The goal was to see if this approach could support healthier eating and …

This study tested whether a blend of digital tools (video sessions and a health app) plus standard in-person care works as well as in-person care alone for children and teens with obesity. About 100 families in Sweden took part. The goal was to see if the digital-physical approac…

This study tested two surgeries for a rare condition where an artery squeezes the small intestine, causing severe nausea, vomiting, and weight loss. 20 adults were randomly assigned to one of two operations and followed for a year. The goal was to see which surgery better relieve…

This study tested a new weight loss program called Med-South, which adapts the Mediterranean diet for Southern tastes, against the popular WW (Weight Watchers) program. Over 2 years, 360 adults with obesity were randomly assigned to one of the two programs. Researchers measured w…

This study tested three different weight loss strategies in 110 adults with chronic spinal cord injury who were overweight. The goal was to see which approach—prepackaged meals, better self-monitoring, or a combined program—helped people lose weight and improve their health. The …

This study tested whether using existing social networks could help Hispanic and Somali immigrants in Minnesota lose weight and improve heart health. About 475 participants joined, and researchers measured weight, waist size, and other health markers over 6 to 12 months. The goal…

This study looked at whether losing weight and making major lifestyle changes can help people with type 2 diabetes who have nerve damage in their feet (diabetic peripheral neuropathy). Researchers measured nerve speed and strength in 50 adults before and after the program. The go…

This study tested a virtual reality (VR) diet program for people with fatty liver disease. The program, called IVAN, teaches healthy eating through an interactive VR experience. 20 adults used the program along with video counseling to see if it could help them lose weight and ea…

This study tested two popular diets—intermittent fasting (eating only during an 8-hour window) and the Mediterranean diet (balanced meals and snacks)—in 120 adults with obesity. Both groups cut 500 calories per day. After 4 weeks, researchers measured weight and body mass index c…

This study tested whether group medical appointments with food deliveries help people manage their weight better than online programs. 43 adults with obesity were randomly assigned to either attend 8 weeks of group visits with cooking classes or complete online nutrition modules,…

This study tested whether a fully automated digital program could help people with prediabetes lose weight and lower blood sugar as effectively as standard programs led by human coaches. About 368 adults with prediabetes and overweight participated. The goal was to find a more ac…

This study tested whether a mindfulness-based training program could help adults who had already lost weight avoid regaining it. 48 participants, including people who had bariatric surgery or lost weight through medical or lifestyle programs, took part. The approach focused on ch…

This study tested a program that connects community resources with doctor's offices to help South Asian adults with pre-diabetes lose weight. The goal was to prevent diabetes by helping participants lose at least 5% of their body weight in 6 months. Nearly 1,000 people took part …

This study tested a 16-week online program called Sleep GOALS to help new mothers lose weight by improving their sleep, diet, and physical activity. Forty women who were 3 to 6 months postpartum and overweight joined the study. The program provided strategies and support through …

This study looked at whether following a very low calorie diet before bariatric (weight-loss) surgery can help patients lose more weight before the operation and feel happier with their care. A total of 85 adults who were eligible for bariatric surgery took part. Researchers meas…

This study tested whether ondansetron, a common anti-nausea medication, helps children aged 2 to 20 better tolerate the bowel preparation needed before a colonoscopy. The goal was to see if it improves bowel cleanliness and reduces discomfort like pain, bloating, nausea, and vomi…

This study looked at how different fiber snack bars affect stomach and bowel symptoms in adults who are already taking weight loss medications like Mounjaro, Ozempic, or Saxenda. Fifty participants tried three types of fiber bars and a control bar for one week each, reporting sym…

This study tested whether using two different injectable treatments together—Sculptra and Restylane—can safely improve cheek fullness and skin quality in adults with moderate-to-severe cheek wrinkles and midface volume loss. 41 participants, some taking weight-loss medications, r…

This study looked at whether adding a low-carb, high-protein diet (like Atkins) to the weight-loss drug semaglutide helps people lose more weight. Sixty overweight or obese adults were split into two groups: one followed the low-carb diet, the other a low-fat diet, for 3 months. …

This study looked at whether losing weight before in vitro fertilization (IVF) helps overweight and obese women have a live birth. Researchers followed 197 women aged 20-36 who were trying to get pregnant for the first time with IVF. Some women followed a diet and exercise progra…

This study looked at how short-term rapid weight loss and exercise change blood cells and immune markers in 9 elite male wrestlers. Participants lost about 4.3% of their body weight over five days. Blood samples were taken before and after exercise, both with and without weight l…

This study looked at whether eating only within a 9-hour window each day (time-restricted eating) plus cutting calories is better for bone health, weight loss, and gut bacteria than just cutting calories alone. The study involved 49 overweight or obese postmenopausal women. Resea…

This study looked at how losing weight affects bone health in overweight or obese men. Researchers measured changes in bone density and quality. The goal was to better understand the relationship between weight loss and bone strength.

This study looked at why many families leave pediatric weight management programs early. Researchers used data from over 1,200 children and their parents to build a tool that predicts dropout. The goal is to help programs keep families engaged and improve long-term health.

This study looked at why people have trouble sticking to a diet and exercise plan during a weight loss program. Researchers used smartphone surveys and Fitbits to track 119 adults with overweight or obesity. The goal was to find out what causes these slip-ups in daily life, so fu…

This study looked at how muscle cells produce energy in women with ovarian or endometrial cancer who have lost weight. Researchers compared women of different body sizes (BMI) to see if muscle metabolism differs. The goal was to better understand the biology behind cancer-related…

This research study looked at how stress, behavior, and social factors affect weight loss and heart health in people from disadvantaged backgrounds. Fifteen adults with overweight or obesity took part. The goal was to learn more about what helps or hinders weight management in th…

This study aimed to understand why some people gain or lose weight more easily than others. Researchers measured how participants' bodies burned calories during periods of controlled overeating and fasting. The goal was to see if these measurements could predict an individual's w…