Fasting at night may cut cancer risk in people with blood disorder precursors

NCT ID NCT05565638

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether fasting for at least 14 hours each night could help overweight people with early blood cancer conditions (MGUS, smoldering myeloma) lose weight and possibly lower their cancer risk. Twenty-three participants were randomly assigned to either the fasting program or a healthy lifestyle education group for 4 months. The main goal was to see changes in body composition, with secondary measures of blood markers related to cancer progression.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

prolonged nightly fasting (behavioral intervention)

What this could lead to

If this works, it could point toward a simple lifestyle change—extending the nightly fast—to help prevent blood cancer in people with early warning signs.

What could go wrong

This is a very small, early study (23 participants) testing weight loss, not cancer directly. The fasting intervention may be hard to stick with long-term, and any cancer benefit is uncertain.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

Fasting monoclonal gammopathy of uncertain significance Smoldering Multiple Myeloma smoldering plasma cell myeloma Waldenstrom macroglobulinemia Weight Loss plasma cell myeloma prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Dana Farber Cancer Institute

    Boston, Massachusetts, 02115, United States