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Could a diabetes drug ease pressure in the brain?

NCT ID NCT06027567

Completed Disease control Sponsor: Rigmor Højland Jensen Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed phase 4 trial tested whether a rapid weight loss program using semaglutide (Ozempic/Wegovy) plus a very low calorie diet can help people with idiopathic intracranial hypertension (IIH), a condition where high pressure in the skull causes headaches and vision problems. 38 participants with new-onset IIH and a BMI of 27 or higher were randomly assigned to either standard diet counselling or the intensive program. The study measured weight change and intracranial pressure to see if the approach could reduce symptoms.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Semaglutide (also known as Ozempic, Wegovy) combined with a very low calorie diet and dietician counselling
What this could lead to
If successful, this could offer a new weight-loss-based treatment to reduce intracranial pressure and improve symptoms in people with idiopathic intracranial hypertension.
What could go wrong
This is a small, completed phase 4 trial with only 38 participants, so results may not apply to everyone. The very low calorie diet is intense and may be hard to follow, and semaglutide can cause side effects like nausea and vomiting.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

intracranial hypertension Obesity obesity disorder optic papillitis pseudotumor cerebri Weight Loss

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

IDIOPATHIC INTRACRANIAL HYPERTENSION INTRACRANIAL PRESSURE OBESITY PAPILLEDEMA PSEUDOTUMOR CEREBRI SYNDROME WEIGHT LOSS

Contacts and locations

Locations

  • Danish Headache Center, Department of Neurology, Rigshospitalet

    Glostrup Municipality, 2600, Denmark

  • Headache clinic, Department of Neurology, Odense University Hospital

    Odense, Odense, 5000, Denmark

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