WEIGHT LOSS

This study is testing a smartphone app that uses artificial intelligence and cognitive behavior therapy to help people with obesity lose weight and improve body composition. The app tracks food and mood through photos and provides personalized guidance. One hundred adults aged 18…

This study looks at whether taking a daily multivitamin can prevent vitamin and mineral deficiencies in people using GLP-1 weight-loss drugs like tirzepatide. About 246 adults who have been on these drugs for at least 3 months will either receive a multivitamin or a placebo for 1…

This study tested two probiotics, TCI378 and TCI507, to see if they help adults lose weight. About 96 adults with a BMI of 24 or higher or high body fat took part. Researchers measured changes in body fat, cholesterol, and other health markers over time.

This study tests an experimental drug called VK2735 to help people with obesity or overweight lose weight. About 4500 adults without diabetes will receive weekly injections of the drug or a placebo for 78 weeks. The main goal is to see how much weight they lose and if the treatme…

This study tests whether a weight loss program delivered through a patient portal can help overweight adults lose more weight than standard education. About 229 participants will be randomly assigned to either an active coaching group or a comparison group. The goal is to see if …

This study was designed to treat toddler obesity by improving what toddlers eat. Parents would join a free online nutrition program and could also take weight-loss medication. The goal was to help both the parent and toddler lose weight. However, the study was withdrawn before an…

This study looks at how well a weight-loss program works for children and teens with obesity. About 700 kids aged 2 to 18 who are overweight will take part in a program run by their local municipality or hospital. The goal is to help them lose weight and build healthier habits du…

This study tests whether a game-like mobile app, combined with brain-training games, can help overweight men lose weight and keep it off. About 228 men will use either a standard weight-loss app or a gamified version with team challenges and rewards. The goal is to see if making …

This study tests a new medication called aleniglipron in adults with type 2 diabetes who are also overweight or obese. The main goal is to see if the drug is safe and tolerable at different doses. Researchers will also check if it helps with weight loss and blood sugar control. A…

This study tests a new weekly injection called VK2735 to help adults with type 2 diabetes who are overweight or obese lose weight. About 1,100 participants will receive either the drug or a placebo for 78 weeks. The main goal is to see how much weight they lose and if the treatme…

This study tests whether a parent-only program followed by a parent-child program works better for weight loss than the parent-child program alone. It involves 480 rural families with children aged 6-11 who are overweight. Families participate via video calls, and researchers tra…

This study looks at whether helping overweight or obese women lose about 10% of their body weight before getting pregnant can lower the chance of their baby being born with too much body fat or becoming overweight in early childhood. About 240 women (and their partners, if they c…

This study looks at whether mirtazapine, a drug often used for depression, can improve appetite in people with advanced cancer who are losing weight. About 98 patients will receive either mirtazapine or a placebo for 15 to 29 days. The goal is to see if it helps with appetite, sl…

This study tests whether a drug called anamorelin, combined with physical activity and nutritional counseling, can lessen severe fatigue in people with advanced solid tumors that have spread or come back. About 129 participants will receive the drug and support for several weeks.…

This study looks at how the weight-loss drug lorcaserin changes brain activity related to appetite and food intake. About 40 adults with obesity will have brain scans and body composition tests. The goal is to understand which brain areas the drug affects, not to test if it works…

This study aims to find biological markers in the blood that can identify people whose metabolism slows down more than expected during weight loss. Researchers will measure resting metabolic rate and hormone levels in 60 adults with obesity over 18 months. The goal is to understa…

This study will follow 5,000 adults who have had an endoscopic procedure for weight loss or to fix a previous weight-loss surgery. Researchers will track changes in weight, blood pressure, diabetes, and cholesterol over 10 years. The goal is to learn how well these procedures wor…

This study looks at how the liver burns fat and produces sugar in people with NASH (a serious fatty liver disease) who are planning to have weight-loss surgery. Researchers will use special scans to measure these liver functions before and after surgery. The goal is to understand…

This study follows 500 adults with obesity who are trying to lose weight. Researchers collect information like body measurements, blood tests, and lifestyle habits to find out what helps people succeed. The goal is to create personalized weight loss plans based on each person's u…