WEIGHT LOSS

This study tests a new procedure called BEAM (Bariatric Endoscopic Antral Myotomy) to help people with obesity lose weight. The procedure uses a tube down the throat to make small cuts in the stomach muscle, aiming to change how the stomach empties. Twenty adults with a BMI betwe…

This study tests whether two probiotic supplements, TCI378 and TCI507, can help adults lose weight and improve blood fats. 96 participants with a BMI of 24 or higher (or high body fat) take one capsule daily for two months. Researchers will measure changes in body fat, cholestero…

This study uses brain scans (fMRI) to see how the weight-loss drug lorcaserin changes activity in brain areas that control appetite and food intake. Forty obese adults will receive either lorcaserin or a placebo pill. Researchers will also measure changes in body composition. The…

This study tests a new daily pill, aleniglipron, in 58 adults with type 2 diabetes who are overweight or obese. The main goal is to check if the drug is safe and tolerable at different doses. Researchers will also measure weight loss and blood sugar changes. The study is not yet …

This phase 3 trial is testing a weekly injection called VK2735 to help people with type 2 diabetes who are overweight or obese lose weight. About 1,100 participants will receive either the drug or a placebo for 78 weeks. The study measures how much weight they lose and whether th…

This study tests whether a parent-only weight loss program followed by a family healthy lifestyles program works better than the family program alone. It involves 480 rural families with a child aged 6-11 who is overweight and a parent with a BMI between 25 and 50. The goal is to…

This study tests whether a gamified mobile health program, including a neurotraining video game, can help overweight men lose weight. 228 men will use either a standard mHealth app or a fully gamified version with team competition and digital rewards. The goal is to see if gamifi…

This study is testing a smartphone app that uses artificial intelligence and cognitive behavior therapy to help people with obesity lose weight and improve their health. About 100 adults aged 18 to 65 with a BMI of 27 or higher will use the app for 12 months. The app tracks food …

This study will follow 5,000 adults who have had endoscopic procedures for weight loss, such as stomach stapling through a scope or gastric balloons. Researchers will track weight, blood pressure, diabetes, and cholesterol for up to 10 years to see how well these procedures work …

This study tests an experimental drug called VK2735, given as a weekly injection, to help people with obesity or overweight lose weight. About 4500 adults without diabetes will receive either the drug or a placebo for 78 weeks. The main goal is to see how much weight they lose an…

This study tests whether a weight loss program delivered through a patient portal (like a health app) helps overweight adults lose more weight than standard health education. About 250 participants will be randomly assigned to either the active program or a comparison group. The …

This study was designed to treat toddler obesity by improving the food environment at home. Parents would take part in a free online nutrition program and could also take weight-loss medication. The goal was to help both parent and child lose weight. However, the study was withdr…

This study looks at whether taking a daily multivitamin can prevent vitamin and mineral deficiencies in people using GLP-1 drugs (like tirzepatide) for weight loss. About 246 adults with obesity who have been on a stable GLP-1 dose for at least 3 months will be randomly assigned …

This study evaluates a weight-loss program for children aged 2-18 with obesity in Denmark. The program involves diet changes, physical activity, and counseling for the whole family. Researchers will track changes in BMI and motivation to see if the program helps kids achieve a he…

This study compares time-restricted eating (eating only between 12pm-8pm) to daily calorie restriction for weight loss and colorectal cancer risk reduction in 193 obese adults aged 45-70. Participants follow their assigned diet for 6 months, then a maintenance phase for another 6…

This study tests whether a weight loss program for overweight or obese women (and their partners) before pregnancy can reduce the risk of their child becoming overweight. 240 couples are randomly assigned to either a very low-calorie diet and counseling or no intervention. The ma…

This study tests whether a drug called anamorelin, combined with physical activity and nutritional counseling, can reduce severe fatigue in people with advanced solid tumors that have spread or returned. About 129 participants with incurable cancers and high fatigue levels will r…

This study looks at whether mirtazapine, a drug often used for depression, can improve appetite in people with advanced cancer who have lost weight and have little desire to eat. About 98 patients will receive either mirtazapine or a placebo for 29 days. Researchers will track ch…

This study looks at how the liver burns fat and makes sugar in people with NASH (a serious liver disease linked to obesity) who are planning to have weight-loss surgery. Researchers will use special scans to measure liver function before and after surgery in 30 adults. The goal i…

This study follows 500 obese adults to see how different factors like diet, exercise, stress, and sleep affect weight loss. Researchers collect blood tests, measurements, and questionnaires at the start and during follow-up. The goal is to find patterns that could lead to more pe…

This study aims to find biomarkers that identify people at risk of a disproportionate drop in resting metabolic rate during and after weight loss. Sixty participants with obesity will follow a 6-month meal replacement program with lifestyle advice. Their resting metabolic rate an…