Can we predict weight loss slowdown? new study seeks biomarkers

NCT ID NCT05139420

Ongoing Knowledge-focused Sponsor: Medical College of Wisconsin Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study aims to find biomarkers that identify people at risk of a disproportionate drop in resting metabolic rate during and after weight loss. Sixty participants with obesity will follow a 6-month meal replacement program with lifestyle advice. Their resting metabolic rate and hormone levels will be measured over 18 months to understand why some people's metabolism adapts more than others.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: meal replacement program and lifestyle advice
What this could lead to: If successful, this could help identify people at risk of metabolic slowdown during weight loss, leading to more personalized weight management strategies.
What could go wrong: This is an observational study with only 60 participants, so results may not apply to everyone. It does not test a new treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder Weight Loss

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OBESITY WEIGHT LOSS

Contacts and locations

Locations

Medical College of Wisconsin

Milwaukee, Wisconsin, 53226, United States

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Other studies related to the condition(s) this trial covers.