Can we predict weight loss slowdown? new study seeks biomarkers
NCT ID NCT05139420
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study aims to find biomarkers that identify people at risk of a disproportionate drop in resting metabolic rate during and after weight loss. Sixty participants with obesity will follow a 6-month meal replacement program with lifestyle advice. Their resting metabolic rate and hormone levels will be measured over 18 months to understand why some people's metabolism adapts more than others.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
meal replacement program and lifestyle advice
What this could lead to
If successful, this could help identify people at risk of metabolic slowdown during weight loss, leading to more personalized weight management strategies.
What could go wrong
This is an observational study with only 60 participants, so results may not apply to everyone. It does not test a new treatment.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Medical College of Wisconsin
Milwaukee, Wisconsin, 53226, United States