WEIGHT LOSS

This study tests whether matching weight-loss medications to a person's specific obesity type (like 'hungry brain' or 'emotional hunger') helps people with bipolar disorder lose weight safely. About 100 adults aged 18-65 will take one of three FDA-approved drugs or join a weight-…

This study looks at people who had a sleeve gastrectomy but regained weight. It compares three different follow-up surgeries to see which one helps them lose the most weight with the fewest side effects. The goal is to find the best option for long-term weight control and better …

This study tests whether a daily postbiotic gummy, combined with nutritional advice, can help overweight or obese adults lose body fat and improve metabolism. About 114 participants will be randomly assigned to receive either the active gummy or a placebo for 12 weeks. Researcher…

This study looks at whether time-restricted eating (eating only during a set window each day) can help adults who have recently lost weight avoid gaining it back. Researchers will track changes in weight and body fat over 12 months in 110 participants. The goal is to find a simpl…

This study looks at whether adding protein supplements to a weight-loss plan (diet and the drug semaglutide) helps overweight or obese adults lose more weight, keep muscle, and avoid gaining weight back. About 140 people will take part, with some getting just diet, some diet plus…

This study aims to find the best combination of strategies to help people maintain weight loss after losing weight. Over 500 adults with obesity will first lose weight through a 16-week program, then try different support methods—like limiting food variety, home strength training…

This early-phase study tests whether semaglutide, a drug used for diabetes and weight loss, can help reduce alcohol use in adults who have had weight-loss surgery and also struggle with alcohol use disorder. Ten participants will take the medication for three months and be follow…

This study looks at whether a program where parents and children work together can help them lose weight and be healthier. About 90 families will take part, with parents joining a weight loss program while their children also get support. The goal is to see if this team approach …

This study looks at whether a 6-month lifestyle program or the medication metformin is better for helping mothers lose weight after having a baby and dealing with gestational diabetes. About 60 women who gave birth in the last 3 to 12 months and have a BMI between 25 and 45 will …

This study looks at whether people who had a procedure called endoscopic sleeve gastroplasty (ESG) to help with obesity keep the weight off for five years or more. Researchers will follow 100 adults who had ESG at least five years ago to measure their weight loss. The goal is to …

This study looks at whether a probiotic called Lactobacillus paracasei LC-19 can help overweight or obese adults lose weight and improve metabolism. About 140 people will take part, with some receiving the probiotic, some receiving the weight-loss drug semaglutide, and others a p…

This study looks at whether a strict low-carbohydrate diet combined with lifestyle guidance can help obese men (BMI 30 or higher) lose weight and improve their fertility. About 98 men aged 22-40 and their partners will take part. The goal is to see if weight loss leads to better …

This study looks at whether doing aerobic exercise before eating (fasted) is better for heart health and weight loss than exercising after a meal. Over 16 weeks, 40 adults with obesity will follow an exercise program either fasted or fed. Researchers will measure changes in body …

This study tests whether adding sleep health coaching to a diet and exercise program can help lower blood pressure and improve overall health. Researchers will work with 150 adults in underserved NYC neighborhoods who have high blood pressure. Participants will attend group sessi…

This study explores whether changing gut bacteria with antibiotics can prevent weight regain after losing at least 10% of body weight. Researchers will give antibiotics or a placebo to 200 adults with obesity (BMI 28-35) and track weight and microbiome changes. The goal is to fin…

This study looks at whether extra help from a dietitian can help active duty women lose weight and get fit after their first baby. About 74 women will either get virtual diet coaching or standard care for a year. The goal is to see if more women can meet military weight and fitne…

This study tests if the drug efsubaglutide alfa can help people who are still obese 6 months after metabolic surgery lose more weight. About 60 adults aged 18-55 with a BMI of 28 or higher will receive either the drug or a placebo. The main goal is to see how much weight they los…

This study looks at whether a procedure called TORe, combined with intensive lifestyle changes, helps people who have regained weight after gastric bypass surgery lose weight again. About 108 adults who regained at least 20% of their lost weight will be randomly assigned to eithe…

This study tests whether a minimally invasive stomach-shrinking procedure (endoscopic sleeve gastroplasty) combined with lifestyle changes is better than lifestyle changes alone for treating a serious liver condition called MASH in people with obesity. The procedure reduces stoma…

This study tests a family-centered program to help Hispanic families lose weight and prevent obesity. Over 1,300 parents and their children ages 8-12 will receive text messages and support to build healthy habits. The goal is to find the best way to help families achieve lasting …

This study tests a new weight loss program for young adults ages 18 to 40 who are overweight or obese. It combines a smartphone app with behavioral coaching to help participants lose weight over 6 months. The goal is to find better ways to help young people manage their weight an…

This study is testing a smartphone app designed to help teenagers with obesity lose weight. The app is based on the idea that replacing unhealthy eating habits with healthy coping skills can lead to weight loss. About 38 teens aged 14-21 will try the app and provide feedback on h…

This study tests whether a mild electrical current applied to the scalp (TDCS) can reduce food intake and help with weight loss. About 148 obese adults aged 18-60 will receive either real or fake TDCS sessions three times a week for four weeks, while also following a reduced-calo…

This study tests whether megestrol acetate, a drug that boosts appetite, can prevent weight loss in people with locally advanced colorectal cancer who are receiving chemotherapy before surgery. About 60 adults will be randomly assigned to get either megestrol acetate or a placebo…

This study tests whether adding a special mix of essential amino acids and carboxylic acids (EAA-AC) to a low-calorie, low-protein diet helps people with severe obesity lose more weight and maintain muscle mass. Sixty adults aged 45-65 with a BMI over 35 will be randomly assigned…

This study looks at how GLP-1 medications (like Ozempic) affect people's feelings about food and what they choose to eat. Researchers will use a virtual reality buffet to measure changes in food selection before starting the medication and after three months. The goal is to under…

This study looks at how quickly losing water weight affects combat athletes' sleep quality, mental sharpness, and muscle strength. Researchers will monitor 12 athletes before and after rapid weight loss using sleep trackers, strength tests, and thinking tasks. The goal is to unde…

This study looks at how losing weight and improving diabetes after bariatric surgery changes brain function and thinking skills. Researchers will also test if a non-invasive nerve stimulation device, started 30 days after surgery, can further improve brain health. The study invol…

This study looks at whether eating peanuts every day can improve bone health, metabolism, and physical function in overweight older adults (ages 50-75) who are trying to lose weight. Participants will be randomly assigned to eat either a daily peanut snack or a nut-free snack for…

This study looks at whether intravenous (IV) fluids given to mothers before delivery are linked to how much weight newborns lose in their first two days. Researchers will review medical records of 200 mothers and their full-term, formula-fed babies. The goal is to understand if I…

This study creates a registry to collect information on endoscopic bariatric therapies (EBTs), which are non-surgical procedures for weight loss. Researchers will review medical charts and follow up to 9,999 participants for one year to measure weight changes and track any side e…

This study examines how GLP-1 receptor agonists (like semaglutide) affect taste perception, food preferences, and eating behaviors in adults with obesity. Researchers will review medical records and surveys from 150 participants treated at Italian clinics for at least 12 weeks. T…

This study looks at tiny particles released by fat cells, called adipocyte-derived extracellular vesicles (Ad-EVs), and how they relate to blood vessel function in people with obesity. Researchers will compare normal-weight and obese adults, then test whether weight loss improves…

This study looks at how adding exercise to a weight loss plan changes belly fat and metabolism in ways that may keep you healthier even if you regain some weight. Researchers will compare two groups of adults with obesity: one that loses weight through diet and exercise, and anot…

This study looks at how tirzepatide, a weight-loss drug, affects muscle mass and strength in adults aged 50 and older with obesity. Researchers want to know if losing weight with this drug also causes harmful muscle loss that could lead to weakness or frailty. Twenty participants…