WEIGHT LOSS

This study is testing whether adding a special amino acid supplement to a low-calorie diet helps people with severe obesity lose weight while keeping their muscle mass. Researchers will compare two groups: one gets the supplement with their diet, and the other gets a placebo. The…

This study is checking if the weight-loss drug tirzepatide causes older adults to lose too much muscle along with fat, which could lead to weakness. Researchers will give 20 obese adults over age 50 tirzepatide for six months and measure their muscle mass, strength, and walking a…

This 12-month study is testing whether limiting daily eating to a 10-hour window helps people maintain recent weight loss. It will compare this time-restricted eating approach to general weight maintenance advice in 110 adults. The goal is to see which method is better at prevent…

This study is testing whether exercising before breakfast (fasted) is better for heart health and weight loss than exercising after eating. Researchers will compare the two approaches over a 16-week supervised exercise program with 40 adults who have overweight or obesity. They w…

This pilot study is testing a new smartphone app designed to help teens with obesity manage their weight. The app is based on a theory that suggests replacing unhealthy eating habits with positive coping behaviors. Researchers will enroll 38 adolescents to test the app's usabilit…

This study is testing whether a non-surgical, endoscopic procedure called TORe, combined with intensive lifestyle coaching, helps people lose weight again after they have regained it following gastric bypass surgery. It will compare this combined approach to lifestyle coaching al…

This study aims to find out if a 6-month lifestyle program or the medication metformin works better for weight loss in mothers who recently had gestational diabetes. Researchers will enroll 60 postpartum women and track their weight, diet, and activity. The goal is to help contro…

This study is testing whether a new medication called aleniglipron is safe and helps with weight loss and blood sugar control in adults with type 2 diabetes who are overweight or have obesity. About 50 participants will take either the drug or a placebo (inactive pill) daily for …

This study is testing if a coordinated weight loss program for a parent and child together works better than separate programs. It involves 90 families where both the child and a parent are overweight. Researchers will compare three approaches: the child's program alone, both pro…

This study is testing if changing gut bacteria with a short course of antibiotics can help people keep weight off after successful dieting. Researchers will enroll 200 adults with obesity who first complete a personalized weight loss program. Participants will then receive either…

This study aims to see if a specific probiotic (LC-19) can help with weight loss and improve metabolism as effectively as the medication semaglutide. It will involve 140 adults, most of whom are overweight or obese, who will follow a diet and lifestyle plan while also taking eith…

This study is testing whether a new injectable medication called VK2735 can help people with type 2 diabetes lose weight and better manage their condition. About 1,100 adults who are overweight or obese will receive either the medication or a placebo injection for 78 weeks. Resea…

This study aims to find the best weight loss medication for people with bipolar disorder by first identifying their specific eating patterns, like 'emotional hunger' or 'hungry gut.' Researchers will match 100 participants to one of three FDA-approved weight loss drugs or a no-me…

This study aims to see if people maintain significant weight loss five or more years after having an Endoscopic Sleeve Gastroplasty (ESG), a non-surgical procedure that reduces stomach size. Researchers will collect past data and conduct one new visit with 100 adults who had the …

This study is testing whether a minimally invasive endoscopic procedure to reduce stomach size, combined with lifestyle changes, is better than lifestyle changes alone for treating a serious fatty liver disease called MASH in people with obesity. Researchers will compare the two …

This study is testing a 6-month program that combines personal coaching with smartphone apps and activity trackers to help young adults lose weight. Researchers want to see if this tech-supported approach is more effective than standard methods. About 140 participants will track …

This study aims to find the best second surgery for people who have regained weight after an initial gastric sleeve procedure. Researchers will compare three different types of follow-up surgeries in 234 participants to see which one leads to the most weight loss, the fewest comp…

This study is testing whether a gentle, non-invasive electrical stimulation to a specific part of the brain can help people eat less and lose weight. Overweight adults will receive either real or fake stimulation while following a reduced-calorie diet for several weeks. Researche…

This study is testing whether one-on-one virtual coaching from a dietitian helps active-duty military women lose weight gained during pregnancy more effectively than standard postpartum care. It will follow 74 first-time mothers for a year after birth, tracking their weight, diet…

This study is testing whether a daily gummy containing a special inactivated microorganism (a postbiotic) can help people who are overweight or obese. For 12 weeks, 114 participants will follow general nutrition advice and take either the postbiotic gummy or a placebo gummy. Rese…

This study aims to find the best combination of support methods to help people maintain weight loss after they've lost weight. Researchers will test four different approaches—including limiting food variety, home exercises, buddy support, and coping workshops—in various combinati…

This study is testing a medication called efsubaglutide alfa to see if it can help people who are still obese six months after having metabolic (weight loss) surgery. It will involve 60 participants who will receive either the real drug or a placebo (dummy treatment) to compare r…

This study aims to find the best family-centered program to help Hispanic parents and children lose weight and prevent obesity. Researchers are testing a mobile health intervention that uses text messages and video calls to promote healthy eating and activity habits. The program …

This study is testing if a drug called megestrol acetate can help people with locally advanced colon or rectal cancer avoid losing weight during chemotherapy given before surgery. The trial will involve 60 patients, with half receiving the drug alongside their standard chemo and …

This study looks back at medical records to see if the amount of IV fluids a mother receives during labor is linked to how much weight her newborn loses in the first two days. It focuses on babies who are fed only formula. The goal is to better understand this common weight loss …

This study aims to understand how weight loss and improved diabetes control after bariatric surgery affect brain function and thinking. Researchers will follow 120 participants, testing their memory and brain scans before surgery, after 12 weeks, and at 18 months. They will also …

This study aims to understand how popular GLP-1 weight loss medications change a person's relationship with food. Researchers will use a virtual reality buffet to observe the food choices of 25 adults before and after they start taking the medication. The goal is to learn how the…

This study aims to understand the effects of rapid weight loss through dehydration on combat athletes. Researchers will measure how this practice impacts sleep quality, mental sharpness, and muscle performance during maximum effort. The findings are intended to help athletes, coa…