Probiotics vs. Weight-Loss drug: which helps you shed pounds?
NCT ID NCT06989177
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether a probiotic (Lactobacillus paracasei) or the drug semaglutide can help overweight or obese adults lose weight and improve metabolism. Over 12 weeks, 140 participants will follow a reduced-calorie diet and lifestyle program while taking one of these or a placebo. The goal is to see which approach works best for weight loss and long-term health.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Lactobacillus paracasei LC-19 (a probiotic) and semaglutide (a weight-loss drug)
- What this could lead to
- If successful, this could show that a specific probiotic helps with weight loss and metabolic health, offering a natural alternative or complement to drugs like semaglutide.
- What could go wrong
- This is a small, early-stage trial (140 people) with no phase designation. Results may not apply to everyone, and probiotics often have modest effects. Side effects or lack of long-term benefit are possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences
RECRUITINGHangzhou, Zhejiang, 310024, China
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