Gut bacteria tweak may curb weight regain
NCT ID NCT06681246
First seen Jun 27, 2026 · Last updated Aug 12, 2026 · Updated 2 times
Summary
This study explores whether changing gut bacteria with antibiotics can help people keep weight off after losing at least 10% of their body weight. 200 adults with a BMI between 28 and 35 will take either antibiotics or a placebo for 10 days. Researchers will track weight, microbiome changes, and blood sugar responses to see if this approach could prevent the common cycle of weight regain.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Antibiotics (Augmentin) or placebo
- What this could lead to
- If it works, this could point toward a new way to prevent weight regain after dieting by targeting gut bacteria.
- What could go wrong
- This is an early exploratory study, not a treatment trial. Antibiotics can have side effects and may not prevent weight regain. Results may not apply to everyone.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for OBESITY are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Weizmann Institute of Science
RECRUITINGRehovot, Israel
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a new stomach and gut bypass surgery tackle obesity and diabetes?
- Can a Two-Drug combo tip the scales against obesity?
- Can Weight-Loss surgery change how medications work?
- Coffee grounds probiotic could reshape gut health and fight inflammation
- Can shedding pounds reboot the Heart's exercise engine?
- Can stomach surgery alter how painkillers work?