Can a lifestyle program beat a pill for Post-Diabetes weight loss?

NCT ID NCT06948825

Recruiting now Disease control Sponsor: George Washington University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a 6-month lifestyle program (diet, exercise, coaching) or the drug metformin is better for weight loss in mothers who recently had gestational diabetes. Sixty women who gave birth in the last year will join. Participants track their activity and weight, attend online group sessions, and may get extra support like free groceries. The goal is to find the most effective way to help these mothers lose weight and improve their health.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Metformin (a diabetes medication) and a lifestyle program (diet, exercise, and coaching)
What this could lead to: If it works, this could show that a lifestyle program is as good as or better than metformin for helping mothers lose weight after gestational diabetes, pointing toward a non-drug option.
What could go wrong: This is a small, early-phase study with only 60 people. Results may not apply to everyone, and weight loss can be hard to maintain. Metformin can cause stomach upset.

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Conditions

The condition(s) this trial relates to.

gestational diabetes Weight Loss

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GESTATIONAL DIABETES MELLITUS IN PREGNANCY POSTPARTUM CARE WEIGHT LOSS

Contacts and locations

Locations

Milken Institute School of Public Health - The George Washington University
RECRUITING

Washington D.C., District of Columbia, 20052, United States

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