George Washington University

This trial tests whether taking inulin, a type of dietary fiber, for two weeks can improve cardiovascular health, muscle function, and the balance of gut and vaginal bacteria in perimenopausal women who are overweight or have obesity. Participants will take either inulin or a pla…

This pilot trial tests whether intravenous zanamivir, a drug already used for flu, can reduce vascular permeability — the dangerous blood vessel leakage that is the main cause of death in dengue fever. About 74 people with dengue and warning signs will receive either zanamivir or…

This study looks at how long hormone-blocking therapy given before surgery (neoadjuvant endocrine therapy) affects breast cancer in people with early-stage disease. About 90 participants will receive therapy for different lengths of time, from weeks up to a year. Researchers want…

This study tests whether sending text message reminders can help homeless people with uncontrolled type 2 diabetes better manage their condition. One hundred participants will receive SMS prompts for medications and appointments. The goal is to see if this simple approach lowers …

This study tests whether a 6-month lifestyle program (diet, exercise, coaching) or the drug metformin is better for weight loss in mothers who recently had gestational diabetes. Sixty women who gave birth in the last year will join. Participants track their activity and weight, a…

This study tests a suicide prevention program called HAVEN-Connect in African American churches. The program teaches youth and adults skills to build supportive relationships, find purpose, and seek help. Researchers will enroll 240 participants from predominantly Black churches …

This study tests a community program in Washington, DC that offers youth aged 12-16 training and mentoring to pursue non-violent life paths, supported by a social media campaign. Researchers will survey 1000 participants and track local violence data to see if the program reduces…

This study compares different doses of iron in daily prenatal supplements to see which best prevents moderate to severe anemia in pregnant women. Pregnant women under 20 weeks gestation are randomly assigned to receive a supplement with 30 mg, 45 mg, or 60 mg of iron daily until …

This study tests whether combining a community-mobilisation program (SASA! Together) with a women's economic empowerment program (Moyo Olemekeza) can reduce intimate partner violence in Malawi. About 1700 women aged 18-49 in food-insecure households will take part. The goal is to…

This study tests a community-mobilisation program called SASA! Together to prevent intimate partner violence in Malawi. About 4800 women and men aged 18-49 who have been in a romantic relationship will take part. The program works with entire communities to change attitudes and b…

This study tests whether taking CoQ10 and glutathione before and after heart surgery can prevent acute kidney injury, a common complication. 242 adults scheduled for elective heart surgery will receive either the supplements or a placebo. The goal is to see if these mitochondrial…

This trial tests whether teaching people how to do everyday tasks soon after wrist fracture surgery improves their recovery. Participants who had surgery for a broken wrist will either receive standard post-surgery instructions or additional guidance on performing daily activitie…

This study compares two types of nerve blocks for pain relief after lung cancer surgery. One block is done before surgery near the spine, the other during surgery between the ribs. Researchers will measure pain scores and how much additional pain medication patients need. The goa…

This study tests whether injecting a numbing medicine (bupivacaine) near the spine can reduce pain and the need for opioid painkillers after lung surgery. Researchers will track pain scores and medication use in 70 adults undergoing lung tumor removal. The goal is to find a safer…

This study looks at whether doing daily activities early after a wrist fracture (treated with a cast) helps people recover better. 64 adults will be split into two groups: one gets instructions on how to safely use their injured hand, the other gets only cast care advice. Researc…

This study tests whether a single injection of a long-acting anesthetic (Exparel) can control pain as well as a catheter that delivers continuous anesthetic after leg fracture surgery. Ninety adults with closed leg fractures will receive either the single shot or the catheter bef…

This study aims to collect saliva samples from 1,000 people with a lab-confirmed diagnosis of MuSK myasthenia gravis, a rare autoimmune condition that weakens muscles. By comparing genetic information, researchers hope to identify variations linked to the disease. The findings co…

This study is following over 267,000 pregnant women in low- and middle-income countries to understand what factors lead to complications like stillbirth, maternal death, and preterm birth. Researchers will collect data on health risks and outcomes to create a large, harmonized da…

This study is testing whether giving healthy adults a controlled dose of whipworm eggs is safe and can cause a mild infection. Researchers will try different egg doses in 18 volunteers to find the best balance of safety and infection. The goal is to create a reliable human infect…

This study follows 3,600 overweight or obese teenagers who are at high risk for developing type 2 diabetes. Researchers will monitor changes in blood sugar, insulin, and other factors over time to learn how the disease starts. No treatments or medications are given—the goal is si…

This study looks at whether putting a warning label on foods with non-sugar sweeteners (like diet drinks) changes what Brazilian parents buy for their children. About 1,068 parents will pick items like yogurt and cereal bars for their kids, either seeing no label, a Mexican-style…

This study tests a program to help families in Armenia and Georgia create smoke-free homes, aiming to reduce secondhand smoke exposure and tobacco use. About 550 adults who smoke at home or live with a smoker will take part. The program is delivered through local community partne…

This study looks at whether avoiding non-nutritive sweeteners (like those in diet sodas) during pregnancy and breastfeeding can lower babies' risk of obesity and improve mothers' blood sugar control. About 324 pregnant women who regularly consume these sweeteners will be split in…

This long-term study follows 19,000 people with or at risk for HIV in Washington, DC to track their health outcomes and quality of care. Researchers will monitor viral suppression rates and new infections over up to 10 years. The goal is to find ways to improve HIV treatment and …