George Washington University

This study tests whether adding an immune-boosting drug called eftilagimod alpha to standard chemotherapy before surgery can completely eliminate tumors in people with early-stage hormone receptor-positive, HER2-negative breast cancer. About 50 participants will receive the drug …

This study will give 130 pregnant women in Tanzania two different types of prenatal supplements—one with multiple micronutrients (MMS) and one with just iron and folic acid (IFA)—to see which one they like better and causes fewer side effects. Each woman will try both supplements…

This study tests an oral drug called glycerol tributyrate in 24 adults with MELAS or LHON-Plus, two rare mitochondrial diseases that cause severe symptoms like strokes and vision loss. The trial is open-label (everyone gets the drug) and uses each person as their own control over…

This study aims to help 400 male commercial minibus drivers in Nigeria use HIV self-testing and long-acting injectable medications for both HIV treatment and prevention. Drivers will be trained as peer educators to promote these tools among their community. The goal is to make it…

This study tests a new tool to help people in emergency departments and urgent care start and continue taking PrEP, a daily pill that prevents HIV. About 120 people who are eligible for PrEP will use the tool, which is designed to address their medical and social needs. The goal …

This study tests whether adding a ChatGPT-powered chatbot (BeFreeBot) to a standard text-message smoking cessation program helps people quit smoking more effectively. About 150 US adults who smoke will be split into two groups: one gets the usual text messages, the other gets the…

This pilot study will test a World Health Organization stress management course called Self-Help Plus in Colombia. The course uses audio guides and an illustrated booklet over five sessions, led by trained community members. Researchers will enroll 40 adults to see if the program…

This study tests whether sending text messages can encourage homeless adults aged 45-75 to complete colorectal cancer screening. About 588 participants from shelter clinics in New York City will be randomly assigned to receive SMS reminders or standard care. The goal is to see if…