Lifestyle overhaul may ease diabetic nerve pain

NCT ID NCT01565317

Completed Disease control Sponsor: Joslin Diabetes Center Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at whether a 12-week intensive lifestyle program focused on weight loss and diabetes control could improve diabetic peripheral neuropathy, a common nerve complication. Fifty adults with diabetes and a BMI between 30 and 45 took part. The program included diet, exercise, and behavioral support. Researchers measured nerve function using a device that checks the sural nerve.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: lifestyle modification program (diet, exercise, behavioral support)
What this could lead to: If successful, this could show that intensive lifestyle changes and weight loss can help manage or improve diabetic nerve damage.
What could go wrong: This is a small, completed study with only 50 participants. Results may not apply to everyone with diabetes, and lifestyle changes can be hard to maintain long-term.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

diabetic neuropathy diabetic polyneuropathy type 2 diabetes mellitus Weight Loss

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIABETIC POLYNEUROPATHY WEIGHT LOSS

Contacts and locations

Locations

Joslin Diabetes Center

Boston, Massachusetts, 02215, United States

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