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Associations between physical activity and sedentary behavior profiles and carotid intima-media thickness in adolescents with obesity

NCT ID NCT07811115

NEW Sponsor: University of Avignon Source: ClinicalTrials.gov ↗

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Recruiting now This study
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By invitation only
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Completed
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Stopped early
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Cancelled
Cancelled before anyone took part.

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Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
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When the status isn't known

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Status unknown
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First seen Sep 09, 2026 · Last updated Sep 09, 2026

Summary

Physical activity behaviors are key and modifiable factors of cardiovascular health from childhood. They encompass both physical activity, defined as any bodily movement produced by skeletal muscles that results in energy expenditure, and sedentary behavior, characterized by low energy expenditure while awake. Studying these behaviors in their diversity, beyond a simple active-inactive opposition, allows for a better understanding of their effects on health. In adolescents, high levels of sedentary behavior and low levels of physical activity are both associated with an increased risk of overweight or obesity. Current recommendations advocate for at least 60 minutes of moderate-to-vigorous physical activity per day and the reduction of sedentary time. However, more than 80% of French adolescents do not meet these recommendations, a trend that is even more pronounced and problematic among those living with obesity. Pediatric obesity is associated with early alterations in vascular health. Carotid intima-media thickness (cIMT), measured by ultrasound, is a recognized biomarker of future cardiovascular risk. Several studies have shown that sustained physical activity is associated with lower cIMT and better endothelial function, independently of body size. However, the methodological limitations of current studies, and the lack of data specific to adolescents with obesity, highlight the need for further research. This project aims to better understand, in adolescents with obesity, the associations between physical activity and sedentary behavior profiles and physical fitness, on the one hand, and structural parameters, particularly cIMT, and vascular functional parameters known for their value as subclinical biomarkers of cardiovascular risk, on the other hand.

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Study facts

What this study's own registry entry says, in plain language.

Participants

About 108 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2024

Expected to finish

Sep 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adolescents were recruited from the specialized pediatric obesity center (COPS) at the Institut Saint-Pierre (Palavas les Flots, 34)

Ages

11 to 18 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * The parent(s) or legal guardian(s) must have provided parental consent, and the adolescent must have provided their assent. * The adolescent must be affiliated with or covered by a health insurance scheme. * The adolescent must be aged between 11 and 18 years. * The participant must have a Body Mass Index (BMI) Z-score corresponding to obesity (reference: Rolland-Cachera et al., 1991 growth charts). Exclusion Criteria: * The adolescent has a contraindication to physical activity (joint, cardiac, or other). * The adolescent is participating in another study. * The adolescent is within an exclusion period determined by a previous study. * The parent(s) or legal guardian(s) or the adolescent refuses to sign the parental consent or assent form, respectively. * It is not possible to provide the adolescent or the parent(s) or legal guardian(s) with the required information for informed consent.

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Conditions

The condition(s) this trial relates to.

Motor Activity Obesity Patient Compliance Sedentary Behavior

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Obese adolescents

How to take part

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  1. The places running it

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  2. The official record

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    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • Institut Saint Pierre

    RECRUITING

    Palavas-les-Flots, 34250, France

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