Irccs Azienda Ospedaliero-universitaria Di Bologna

This small study tests a new technique to mark suspicious lung nodules before surgery. Using a special imaging system, doctors place a tiny marker near the nodule through a breathing tube, avoiding a needle through the chest. The goal is to make it easier for surgeons to find and…

This study looks at two ways to trigger ovulation in women with cancer who are freezing their eggs before starting cancer treatment. One method uses a single drug (GnRH-a), the other uses a combination of two drugs (GnRH-a plus hCG). The goal is to see which approach collects mor…

This study looks at whether using two antibiotics together is more effective than one for treating Enterococcus faecalis bloodstream infections. Researchers will also analyze patients' gut bacteria to see how it affects treatment success. About 510 adults with this infection will…

This study looks at three different forms of levothyroxine (a thyroid hormone replacement) in 120 children with congenital hypothyroidism. Researchers want to see if a new oral solution works better or safer than the current liquid drops or tablets. The goal is to ensure normal g…

This study tests whether a fecal microbiota transplant (FMT) can help people with advanced liver cancer whose disease got worse on standard therapy. Participants will receive FMT along with the same cancer drugs they previously took. The goal is to see if this approach can restor…

This study tests a new way to scan men with high-risk prostate cancer using a special PET/CT tracer. The approach adds a delayed pelvic image without a second CT scan, reducing radiation exposure and saving time. Researchers will check if the image quality stays good enough to fi…

This study is testing whether measuring how well a pregnant woman's blood vessels work can help predict dangerous conditions like preeclampsia and high blood pressure. Researchers will use two non-invasive devices and blood/urine tests in 400 first-time mothers during early and m…

This study is developing a computer program that can listen to a newborn's heartbeat using a digital stethoscope and tell if it sounds normal or not. The goal is to catch serious heart problems early, reduce false alarms, and lower healthcare costs. Researchers will record heart …

This study looks at whether genetic material from lung cancer cells can be collected from a lung wash (bronchoalveolar lavage) instead of a traditional needle biopsy. Researchers will compare the genetic test results from the wash fluid to those from standard biopsy samples in 10…

This study tests if a doctor-led counseling program, plus two smartphone apps, can help older adults (60+) who have had a liver or kidney transplant eat better and be more active. Sixty participants will first get lifestyle advice, then use the apps for 12 weeks. The main goal is…

This study compares two breathing therapy techniques—standard therapy versus a device called Simeox—in 40 adults with bronchiectasis (a lung condition causing mucus buildup). The goal is to see which method better improves lung function, breathing, and mucus clearance. Participan…

This study looks at information already collected from 600 people with multiple myeloma. Researchers will combine genetic, clinical, and imaging data to find patterns and build computer models that may predict how the disease will progress or respond to treatment. No new tests or…

This study collects medical and genetic information from 520 people with multiple myeloma to better understand why the disease progresses or comes back. Researchers will analyze DNA and RNA from patient samples to find patterns linked to treatment response. The goal is to create …

This study aims to create a national map of cutaneous lymphoma in Italy by collecting data from about 1,000 patients. Researchers will look at medical records and follow patients for two years to see how common these rare skin cancers are and if they are linked to environmental f…

This study looks at whether a new way of scoring whole-body MRI scans can reliably measure bone inflammation in children with a rare condition called CRMO. Researchers will compare the MRI scores from different doctors and also check if the scores match the child's symptoms. The …

This study is for 100 people with early-stage lung cancer who will have surgery. Researchers will measure cancer cells in the blood and lymph nodes to see if these levels can predict if the cancer will come back. The goal is to better understand how lung cancer spreads and improv…

This study looks at cholesterol and blood sugar levels in 200 people with Noonan syndrome and related conditions, aged 2 to 35. Researchers want to see if these levels differ by age, sex, or genetic cause. No treatment is given—the goal is to gather information to improve future …

This study looks at 300 children with central precocious puberty (early puberty) to see how often it happens on its own versus with a brain development condition. Researchers will compare the children's growth and diagnosis details. The goal is to better understand the link betwe…

This study looks at children who received radiation therapy for cancer to understand their risk of developing thyroid nodules or thyroid cancer later in life. Researchers will track 2,550 participants to find out how common these thyroid problems are and what factors increase the…

This study aims to understand how common antibiotic-resistant bacteria are in the gut of people using PrEP (HIV prevention medication). Researchers will collect samples from 200 HIV-negative adults aged 18-45 during routine check-ups. The goal is to gather data that could lead to…

This study aims to find genetic markers that make some women more likely to experience early menopause after chemotherapy for breast cancer or Hodgkin lymphoma. Researchers will analyze stored ovarian tissue from 50 women who had fertility preservation before treatment. The goal …

This study looks at two ways to help cancer patients preserve their ability to have children before treatments like chemotherapy. One method freezes both ovarian tissue and eggs, while the other freezes only eggs. Researchers will compare how many eggs are retrieved in each group…

This study looks at 520 children and teens with a rare condition called 46, XY DSD, where a person's chromosomes (XY) don't match their physical sex development. Researchers will collect genetic and physical information to better understand the condition. The goal is to learn mor…

This study looks at children born in Italy between 2016 and 2020 who were found to have biotinidase deficiency through newborn screening. Researchers want to see if there is a link between the specific gene changes and the symptoms or lab results. The goal is to better understand…

This study looks back at 200 patients who received a large metal implant in their lower leg between 2020 and 2023. Researchers want to learn how many get infections and what factors increase that risk. No new treatments are tested—the goal is simply to gather information to impro…

This study aims to see if advanced imaging techniques, like special ultrasound and MRI, can find heart damage earlier in children, teens, and young adults who have had cancer treatment. Researchers will follow 400 participants to track heart problems that may appear during or aft…

This study examines the LEF-1 protein in tissue samples from 350 adults with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). The goal is to see if measuring LEF-1 helps doctors diagnose these diseases more accurately and identify new markers for prognosis …

This study aims to find genetic reasons why some children have permanent congenital hypothyroidism even though their thyroid gland is in the right place. Researchers will analyze DNA from 350 children born between 2003 and 2023 in the Emilia-Romagna region of Italy. The goal is t…

This study watches 500 people who are offered weight-loss drugs like Wegovy or Mounjaro. It aims to understand who accepts the prescription and why, based on their health history and lifestyle. For those who start the drugs, researchers will track how well the treatment works and…

This study looks at how to better track blood pressure and fluid loss in babies (3-8 months old) having skull surgery for craniosynostosis. Researchers will compare standard monitoring with a newer method called PRAM to see which gives a clearer picture of the baby's condition du…

This study looks at how gut bacteria and the immune system interact in children and adults receiving stem cell transplants or CAR-T therapy. Researchers will collect stool and blood samples before and after treatment to find patterns linked to complications like infections or gra…

This study looks at 60 people with rare lymphomas that are hard to tell apart—either a type of Hodgkin lymphoma missing a key marker (PAX5) or a similar-looking T-cell lymphoma (ALCL). Researchers will examine the cells' features and genetics to find patterns that help make a cle…

This study looks at how chemical changes to DNA, called methylation, differ in brain, thyroid, and endometrial cancers. By analyzing tumor samples from 180 people, researchers hope to create better ways to classify these cancers and find new targets for diagnosis. The goal is to …

This study looks at 25 adults with COPD and high carbon dioxide levels who need a breathing machine at night. Researchers want to see if problems breathing during sleep can predict how well the machine works over 6 to 12 months. The goal is to better understand who benefits most …

This study looks at newborns who lose too much salt due to rare hormone problems that look like a common condition (congenital adrenal hyperplasia) but are not caught by standard newborn screening. Researchers will track 25 patients to find out how often these rare conditions hap…

This study follows 500 transgender adults who have been on gender-affirming hormone therapy for at least one year. Researchers will measure changes in blood pressure, cholesterol, body composition, and other heart health markers. The goal is to understand long-term cardiovascular…

This study looks for biological markers (biomarkers) in the blood or stool that can help doctors predict how severe gut graft-versus-host disease (GvHD) will become and whether a patient will respond to treatment. GvHD is a serious complication that can occur after a stem cell tr…

This study watches how doctors in Italy use different methods to make the liver grow bigger before surgery for liver tumors. About 2,000 patients will be followed to see which techniques work best for liver growth, survival, and safety. The goal is to learn from real-world practi…

This study uses advanced heart MRI scans to look at blood flow in people with different types of hypertrophic cardiomyopathy (thick heart muscle), including rare forms like Anderson-Fabry disease and cardiac amyloidosis. Researchers will also study first-degree relatives and gene…

This study looks at whether certain substances in the placenta (called sFlt-1 and PlGF) can help doctors know if a baby is in distress during labor. Researchers will monitor 428 pregnant women and compare these markers with standard heart-rate tracings. The goal is to find a bett…

This study looks at whether a type of scan called PSMA PET can help doctors predict how well advanced prostate cancer will respond to treatments like hormone therapy or chemotherapy. Researchers will track 1,300 men with advanced prostate cancer to see if scan results, such as th…

This study is gathering information from 11,000 people who have had a heart attack or heart muscle injury. Researchers will look at what happens to patients over time, including death rates and major heart problems. The goal is to learn more about these conditions so doctors can …

This study looks at how air pollution particles get into the bodies of non-smokers with lung cancer, COPD, or leukemia, and compares them to healthy volunteers. Researchers will use advanced microscopes and chemical tests to find these particles in blood and tissue samples. The g…

This study watches 60 adults with CRE infections (a type of drug-resistant bacteria) who are already receiving one or two antibiotics. Researchers measure drug levels in the blood to see if they hit targets that kill the bacteria. The goal is to learn the best way to use these dr…

This study is not testing a new treatment. Instead, it will follow about 400 adults with advanced heart failure who already need a mechanical heart pump. Researchers will track survival rates and complications over five years to learn how well these pumps perform in real-world us…

This study follows 60 girls with classic galactosemia, a rare genetic condition that prevents the body from breaking down galactose. Researchers want to understand why many of these girls experience early ovarian failure and delayed puberty. By measuring hormone levels and tracki…