Tiny particles in blood may reveal heart transplant rejection without a biopsy

NCT ID NCT07673536

Recruiting now Diagnosis Sponsor: Laurenz Kopp Fernandes Source: ClinicalTrials.gov ↗

First seen Jun 29, 2026 · Last updated Jul 02, 2026 · Updated 3 times

Summary

This study looks at whether proteins carried by tiny particles called extracellular vesicles in the blood can signal when a heart transplant is being rejected. Researchers will track 30 heart transplant patients over 15 months, comparing protein patterns in those with and without rejection. The goal is to find a reliable, non-invasive way to diagnose rejection earlier than current methods allow.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

extracellular vesicle protein profiling (diagnostic test)

What this could lead to

If successful, this could lead to a simple blood test to detect heart transplant rejection early, reducing the need for invasive heart biopsies.

What could go wrong

This is a small, early-stage study (30 participants) focused on finding protein patterns, not yet proving the test works in practice. The identified markers may not be reliable enough for routine use.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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