Tiny particles in blood may reveal heart transplant rejection without a biopsy
NCT ID NCT07673536
First seen Jun 29, 2026 · Last updated Jul 02, 2026 · Updated 3 times
Summary
This study looks at whether proteins carried by tiny particles called extracellular vesicles in the blood can signal when a heart transplant is being rejected. Researchers will track 30 heart transplant patients over 15 months, comparing protein patterns in those with and without rejection. The goal is to find a reliable, non-invasive way to diagnose rejection earlier than current methods allow.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- extracellular vesicle protein profiling (diagnostic test)
- What this could lead to
- If successful, this could lead to a simple blood test to detect heart transplant rejection early, reducing the need for invasive heart biopsies.
- What could go wrong
- This is a small, early-stage study (30 participants) focused on finding protein patterns, not yet proving the test works in practice. The identified markers may not be reliable enough for routine use.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Deutsches Herzzentrum der Charité, Department vor cardio-thoracic and vascular surgery
RECRUITINGBerlin, State of Berlin, 13353, Germany
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