Can online therapy rewire the Brain's pain response in fibromyalgia?

NCT ID NCT07054333

Recruiting now Knowledge-focused Sponsor: Karolinska Institutet Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study aims to objectively measure how internet-based exposure-based cognitive behavioral therapy (Exp-CBT) affects pain regulation in people with fibromyalgia. About 45 participants will undergo pain tests before and after 10 weeks of online therapy to see if their pain thresholds, tolerance, and pain inhibition change. The goal is to understand the mechanisms behind the treatment, not to test its effectiveness directly.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Internet-delivered exposure-based cognitive behavioral therapy (Exp-CBT)
What this could lead to: If successful, this study could reveal how online therapy changes the brain's pain processing, leading to more effective treatments for fibromyalgia.
What could go wrong: This is a small, early mechanistic study with no control group, so results may not prove cause and effect or apply to all patients. The therapy may not work for everyone.

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Conditions

The condition(s) this trial relates to.

fibromyalgia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

FIBROMYALGIA

Contacts and locations

Locations

Karolinska Institutet
RECRUITING

Solna, 17177, Sweden
Nobels väg 9, Neuro
RECRUITING

Stockholm, Stockholm County, 171 77, Sweden

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