Unlocking the genetic roots of fibromyalgia's pain puzzle
NCT ID NCT04624581
First seen Aug 05, 2026 · Last updated Aug 06, 2026 · Updated 1 time
Summary
This study investigates whether genetic differences and altered pain processing contribute to fibromyalgia, a condition marked by widespread pain and increased sensitivity to painful stimuli. Researchers will compare 260 adults with fibromyalgia to a matched control group, measuring pain thresholds via a nerve reflex test and analyzing genetic variations. The goal is to better understand the biological mechanisms behind fibromyalgia, which could inform future diagnostic or treatment strategies.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Electrophysiological measurement of reflex nociceptive flexion threshold (RIII reflex) using Nicolet Vicking device
- What this could lead to
- If successful, this research could uncover genetic markers that help explain why fibromyalgia develops, potentially leading to more personalized diagnosis or treatment approaches.
- What could go wrong
- This is an observational study, so it won't test a treatment. The findings may not directly translate into new therapies, and genetic associations may be complex and require further validation.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
CHU de Clermont-Ferrand
Clermont-Ferrand, 63000, France
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