Fibromyalgia

This study tests a new way to help people with chronic non-cancer pain who have been on long-term opioids. Instead of usual care, a team of doctors, pharmacists, physiotherapists, and psychologists works with the patient to create a personalized plan. The goal is to reduce pain i…

This study tests whether counseling plus a muscle relaxant (tizanidine) can help adults who have used opioids for a long time reduce their pain medication after elective surgery. About 375 participants will be randomly assigned to one of three groups: the combo treatment, counsel…

This study follows 2,000 people with chronic pain who are implanted with Abbott neurostimulators (spinal cord or dorsal root ganglion stimulators). Researchers will track side effects, device problems, and how well the devices control pain over time. It is an observational study,…

This pilot study tests whether artificial intelligence can recognize pain by analyzing facial expressions in people with fibromyalgia. Researchers will compare 61 fibromyalgia patients with 61 healthy volunteers. They will also check saliva samples for biological markers of pain.…

This study compares an online program called Veteran ACT for Chronic Pain (VACT-CP) to another online pain program, Online Pain School, for veterans with chronic pain. The goal is to see which program better helps veterans improve their daily functioning, manage pain, and enhance…

This study tests whether a non-invasive device that stimulates a nerve in the ear can help people with fibromyalgia. Participants use the device for 30 minutes daily over four weeks. The goal is to see if it reduces pain, fatigue, and other symptoms by calming the body's stress r…

This early-phase study tests whether MDMA-assisted therapy can reduce pain in 20 adults with fibromyalgia. Participants receive MDMA combined with psychotherapy and undergo brain scans to see how the drug affects pain and the bond between patient and therapist. The goal is to und…

This study is testing a new type of spinal cord stimulator that automatically adjusts its signal based on how your nerves respond. It aims to improve pain relief and quality of life for 25 adults with long-term, hard-to-treat pain in the trunk or limbs. The device is already appr…

This study tests whether core shamanism—sessions with drumming, rattling, and discussion—can help reduce pain and other symptoms in women with fibromyalgia. Twenty-five participants will attend up to five sessions while researchers measure pain, heart rate, breathing, and brain a…

This study compares two drugs, pregabalin and mirogabalin, to see which works better for fibromyalgia pain. About 674 adults with moderate to severe fibromyalgia who haven't tried these medications will take one of the drugs for several weeks. The main goal is to see how many peo…

This study investigates whether drinking plasma-activated water—water treated with light and nano gold particles to create smaller water clusters—can safely improve symptoms in people with fibromyalgia, a condition causing widespread pain. Researchers will measure changes in bloo…

This study tests whether dance therapy can help teens aged 12-20 with chronic pain feel better and move more freely. 160 participants will either attend weekly dance sessions for 15 weeks or receive standard care. The goal is to see if dancing reduces pain intensity and fear of m…

This study tests whether sleeping with a weighted blanket (about 10% of your body weight) can help adults with chronic pain feel better. About 44 people will use the blanket every night for 5 weeks and report changes in pain, sleep, and daily activities. The goal is to see if thi…

This study tests three types of injections for people with chronic neck and shoulder muscle pain caused by trigger points. It compares platelet-rich plasma (PRP), a mix of PRP and steroid, and steroid alone to see which works best. 150 adults aged 18-65 with a single active trigg…

This study tests two non-invasive treatments—connective tissue massage and vagus nerve stimulation—alone or together, in 66 women with fibromyalgia. The goal is to see if these methods improve pain, sleep, fatigue, and quality of life. Participants will be randomly assigned to on…

This study tests whether acupuncture can make opioid painkillers more effective for people with fibromyalgia. About 45 adults who already take daily opioids will receive either real acupuncture or a sham (fake) version. Researchers will measure pain changes after an opioid dose t…

This study tests whether a non-invasive brain stimulation technique called rTMS can reduce pain and depression in people with fibromyalgia. About 36 adults with chronic pain, some also depressed, will receive either real or sham (fake) rTMS to two brain areas. Researchers will tr…

This study tests whether a non-invasive procedure called vestibulocortical stimulation (VCS) can reduce pain and improve quality of life in people with fibromyalgia. VCS involves gently irrigating the ear canal with temperate water using a plastic syringe. The trial will compare …

This study tests whether using a bright light device for one hour each morning, combined with a consistent sleep schedule, can improve symptoms of fibromyalgia—a condition causing widespread pain and fatigue. Researchers at the University of Michigan are recruiting 390 adults wit…

This study tests whether adding foot reflexology to standard physical therapy can reduce pain and improve sleep in women with fibromyalgia. Sixty women aged 18–65 will receive either standard therapy alone or standard therapy plus foot reflexology twice a week for six weeks. Rese…

This study tests whether a noninvasive ultrasound device can reduce pain in people with fibromyalgia. 180 adults will receive either real or sham ultrasound to a brain area linked to pain, over four sessions in one month. Researchers will track pain scores and symptom impact for …

This study tests a small, FDA-cleared device that gently stimulates nerves in the ear to reduce pain and improve daily function in 240 veterans with fibromyalgia. Half will get the real device, half a sham, and researchers will track pain levels and brain activity over 24 weeks. …

This study tests whether taking oral magnesium can reduce pain and other symptoms in people with fibromyalgia who haven't gotten better with standard treatments. About 86 adults aged 18-65 will be randomly assigned to receive magnesium or a placebo. The main goal is to see if mag…

This study compares two online treatments for chronic pain: an 8-week cognitive behavioral therapy program (16 hours total) and a single 2-hour pain relief skills class. Researchers want to see which works better for reducing pain intensity and interference. The study will enroll…

This study tests a short behavioral treatment delivered over Zoom to help adults with fibromyalgia, lupus, chronic pelvic pain, or chronic low back pain. The goal is to reduce pain, disability, and related issues like anxiety or depression. Participants will learn strategies to m…

This study looks at whether adding esketamine to standard fibromyalgia treatments can reduce pain more quickly and effectively. About 92 adults with fibromyalgia who haven't gotten enough relief from other treatments will take part. Researchers will compare pain levels between th…

This study tests a psychosomatic program for people with fibromyalgia, a condition causing widespread pain. The program combines group talks to reframe how patients think about their symptoms, plus museum therapy. Researchers aim to see if this approach reduces distress and impro…

This study is tracking 970 adults with chronic pain who receive an Inceptiv™ spinal cord stimulator, a device that sends mild electrical pulses to the spine to block pain signals. Researchers want to see if at least half of patients get significant pain relief and better quality …

This study tests whether a device that gently stimulates a nerve in the ear (transcutaneous vagus nerve stimulation) can help people with chronic fatigue from fibromyalgia or long COVID get more benefit from exercise. 60 adults who still feel very tired after a standard exercise …

This study explores whether structured dog-assisted therapy can reduce pain, anxiety, and depression in people with fibromyalgia. Sixty adults with confirmed fibromyalgia will attend 10 sessions with a therapy dog and complete surveys on pain, mood, and daily function. Researcher…

This study tests whether a traditional Chinese herbal formula called Yishen Shujin Decoction can reduce pain and improve quality of life in people with fibromyalgia. One hundred adults with fibromyalgia will receive either the herbal formula or a placebo for 12 weeks, and researc…

This study tests whether an 8-week program of mindfulness and body awareness, held in a university museum, can reduce pain and improve quality of life for women with fibromyalgia. About 44 women will be randomly assigned to either the museum program or a control group. The goal i…

This study looks at whether yoga-based occupational therapy can improve body awareness and daily function in adolescents aged 11-21 with chronic pain. Participants will attend 8-12 weekly yoga sessions and complete questionnaires before and after treatment. The goal is to see if …

This study compares two behavioral programs for people with chronic pain, chronic insomnia, and long-term opioid use. One program uses cognitive behavioral therapy for insomnia (CBT-I), the other is standard treatment. The goal is to see if improving sleep can also reduce opioid …

This study looks at whether adding osteopathic care (a type of hands-on therapy) to a flexible low-FODMAP diet can further reduce IBS symptoms in people with fibromyalgia. About 96 adults will receive either real or sham osteopathic sessions alongside the diet. Researchers will t…

This study tests a group-based parent training program called SPACE-Pain, originally developed for anxiety, to see if it is feasible and acceptable for parents of children aged 10-17 with chronic pain. The program teaches parents to reduce accommodation while staying warm and sup…

This study is testing whether a painless brain stimulation technique called tDCS can reduce chronic pain in 100 military members and veterans. Participants will receive tDCS while taking part in a behavioral health program, and researchers will track changes in pain levels and da…

This study tests whether very short, controlled exercise sessions (called microdoses) can help women with fibromyalgia feel better. Researchers will measure changes in muscle strength, pain, and quality of life in 36 women. The goal is to find a gentle, effective exercise plan th…

This study looks at how three different levels of physical activity—45, 90, or 150 minutes per week—affect arthritis symptoms like pain and mobility. Researchers will enroll 285 adults with arthritis, rheumatoid arthritis, gout, fibromyalgia, osteoarthritis, or lupus. Participant…

This study tests whether low-dose metformin, a common diabetes drug, can improve symptoms of fibromyalgia by reducing inflammation in the nervous system. 72 adults with fibromyalgia will take metformin or a placebo daily for 8 weeks. Researchers will measure changes in pain, fati…

This study tests a high-CBD, low-THC sublingual product against a placebo in 25 adults with chronic pain conditions like arthritis or injury-related pain. Over 9 weeks, researchers will track pain levels, medication use, quality of life, and thinking skills to see if CBD offers r…

This study tests whether a 6-week group pain education program can help people with chronic pain become more active, feel less pain, and have lower depression. Fifty adults with pain lasting over 3 months will attend weekly 2-hour sessions covering sleep, stress, exercise, pain s…

This study tests a faster form of brain stimulation (accelerated TMS) for people with long-term chronic pain that hasn't improved with medication. Researchers will use a smart algorithm to choose the best spot to stimulate each person's brain, based on their individual pain patte…

This study compares two different exercise programs combined with dietary advice to see which better reduces symptoms in people who have both fibromyalgia and irritable bowel syndrome. Researchers will enroll 30 adults aged 30 to 65 with moderate to severe IBS and confirmed fibro…

This study tests a non-invasive brain stimulation technique called deep rTMS to see if it can reduce chronic pain from nerve damage or fibromyalgia. About 70 adults with daily pain will receive either real or fake (sham) treatment over 3 months. The goal is to measure pain relief…

This study tests whether a digital sleep therapy program (Sleepio) can improve quality of life and movement in 142 adults with fibromyalgia who also have trouble sleeping. Participants will use the program at home for 10 weeks and wear devices to track sleep and activity. Researc…

This early-stage study tests whether psilocybin, the active ingredient in magic mushrooms, can help reduce pain, fatigue, and other symptoms in people with fibromyalgia. Researchers will enroll 30 women aged 25-65 who have had widespread pain for at least a year. The goal is to s…

This study looks at whether combining mindfulness training (MBSR) with an open-label placebo—a pill that patients know has no active drug—is a practical way to help people with chronic pain. Researchers will randomly assign 45 adults to receive either mindfulness alone, the place…

This study is testing whether an online course can help people with multiple sclerosis, long COVID, fibromyalgia, or cancer-related fatigue adopt healthier diets and self-care habits. Researchers will measure changes in quality of life, fatigue, and mental health. The goal is to …

This study looks at whether walking outdoors, with help from a treadmill and a mobile app, can improve heart and lung function and quality of life in women with fibromyalgia. About 54 women aged 25-55 who haven't exercised regularly will take part. The goal is to see if this appr…

This study tests a non-invasive brain stimulation technique called HD-tDCS for people with chronic pain that hasn't improved with other treatments. 144 participants will be randomly assigned to receive either real (anodal or cathodal) or sham (placebo) stimulation over five sessi…

This study tests whether personalized exercise and a gentle nerve stimulation device can reduce pain, improve sleep, and ease fatigue in people with fibromyalgia. About 75 adults with fibromyalgia and chronic fatigue will be split into three groups: one gets exercise plus standar…

This study tests whether a team of five pain specialists—including doctors, psychologists, pharmacists, dietitians, and physical therapists—can help veterans with chronic pain feel better and get more out of life. About 150 veterans will either join the program right away or wait…

This study compares two medications, pregabalin and a newer drug called crisugabalin, to see which works better for easing fibromyalgia pain. Over 1,100 adults with moderate to severe fibromyalgia will take one of the two drugs, and researchers will measure how many get at least …

This Phase 3 study tests whether AXS-14 (esreboxetine) can help manage fibromyalgia symptoms like pain and fatigue. About 620 adults with fibromyalgia will take the drug or a placebo daily. The study uses a 'randomized withdrawal' design to see how long the drug's effects last.

This study looks at whether adding magnesium sulfate to a standard lidocaine injection can better relieve pain and improve muscle function in people with myofascial pain dysfunction syndrome (chronic jaw muscle pain). About 28 adults with active trigger points will receive either…

This study tests a smartphone app called QoLibri designed to help people with chronic pain manage their symptoms and improve their quality of life. About 410 adults with moderate or worse pain lasting over 3 months will be randomly assigned to use the app right away or after a wa…

This study is testing a new, noninvasive ultrasound device to see if it can reduce pain and other symptoms in people with fibromyalgia. About 50 adults with fibromyalgia will receive 6 treatment sessions over 2 weeks. Researchers will measure pain levels and symptom impact using …

This study compares taking pregabalin alone versus pregabalin plus venlafaxine for fibromyalgia, a condition causing widespread pain and fatigue. Researchers want to see if the combination provides better pain relief without more side effects. The study will enroll 750 adults wit…

This study compares a video-based exercise program (using Nintendo Switch Ring Fit Adventure) to a standard home exercise program in women aged 30-70 with fibromyalgia. The goal is to see if the game-based approach improves pain, balance, mobility, and quality of life more than t…

This study looks at whether teaching older adults about how pain works, combined with supervised exercise, can reduce chronic pain and improve daily life. One hundred people aged 65 and older with pain lasting over 3 months will be split into three groups: exercise only, exercise…

This study compares a home-use brain stimulation device (tDCS) to the drug duloxetine for treating fibromyalgia in 610 women. Participants use the device daily for 4 weeks or take duloxetine, both combined with exercise and pain education. The goal is to see if tDCS works as well…

This study tests if a type of talk therapy called Emotional Awareness and Expression Therapy (EAET) can help reduce widespread pain in people with lupus. Thirty adults with lupus and fibromyalgia or chronic pain will attend 8 weekly online sessions. Researchers will check if the …

This study tests a single online class called Empowered Relief, delivered in Spanish to adults with chronic pain. The class teaches pain relief skills, and participants fill out surveys right after, at 2 weeks, and at 1 month. The goal is to see if the class is helpful and satisf…

This study tests whether two natural supplements—silymarin (from milk thistle) and a hesperidin/diosmin combination (from citrus)—can reduce pain and improve quality of life in people with fibromyalgia. About 90 adults with fibromyalgia will take one of the supplements or a place…

This study is testing a smartphone app called Digital SPA, designed with input from teens, to help adolescents aged 12–17 manage chronic pain. The app uses Acceptance and Commitment Therapy techniques to reduce pain interference and emergency room visits. About 195 teens and thei…

This study tests whether a combination of psilocybin (the active ingredient in magic mushrooms) and talk therapy can help adults with chronic pain safely reduce or stop their opioid painkillers. Ten participants will receive one or two psilocybin sessions over 8 weeks, with follo…

This study tests a personalized approach to magnetic brain stimulation for people with chronic pain. Instead of a one-size-fits-all treatment, researchers will use each person's brain signals to customize the stimulation. The goal is to improve pain relief for the 90 participants…

This study tests whether adding a nasal spray drug called dexmedetomidine to the standard medication pregabalin can better relieve pain in people with fibromyalgia. The trial will enroll 400 adults with moderate to severe fibromyalgia who haven't found relief from non-drug treatm…

This study tests whether adding a gentle, non-invasive brain stimulation technique called tDCS to a structured pain coping program can help people with fibromyalgia feel better. About 68 adults with fibromyalgia will take part. They will all go through the same program of pain ed…

This study compares pregabalin alone versus pregabalin plus desvenlafaxine for treating fibromyalgia, a condition causing widespread pain and fatigue. Researchers will enroll 384 adults with moderate to severe pain that hasn't improved with non-drug treatments. The goal is to see…

This study compares pregabalin alone versus pregabalin plus toludesvenlafaxine for fibromyalgia, a condition causing widespread pain and fatigue. Researchers will enroll 384 adults with moderate to severe pain that hasn't responded to non-drug treatments. The goal is to see if th…

This study tests whether a 6-week virtual reality exercise program can help people with fibromyalgia manage their symptoms better than standard exercise. 80 adults with fibromyalgia will be randomly assigned to either the VR exercise group or a regular exercise group. The goal is…

This study compares two short behavioral therapies—mindfulness (B-MORE) and cognitive-behavioral therapy (CBT)—for adults with chronic pain. Both treatments are just two hours long and offered in English or Spanish. The goal is to see if these brief programs are practical and acc…

This study tests whether energy healing (a hands-off therapy that aims to balance the body's energy) can reduce pain in women with fibromyalgia. Twenty-five participants will receive both real and fake (sham) energy healing while their brain activity is scanned with fMRI. The goa…

This study tests whether combining cognitive training with electroacupuncture can reduce pain in people with fibromyalgia. Researchers will use brain scans to see if the treatment improves how patient and clinician brains sync up. The trial enrolls 100 adults with fibromyalgia an…

This study tests a new program called PREP-Y, designed to help adolescents aged 12-17 with chronic musculoskeletal pain become more physically active and better manage their pain. The program includes four weekly virtual sessions teaching resilience skills like motivation and cop…

This study is testing whether herbal medicine and vitamin IV therapy can reduce symptoms of anxiety, fibromyalgia, arthritis, chronic pain, and high blood pressure. Researchers plan to enroll 25 people and measure improvements in health and quality of life. The approach uses natu…

This study tests whether a non-invasive brain stimulation technique called rTMS can improve symptoms of major depression and chronic pain at the same time. Fifty-four adults with moderate depression and pain will receive 30 sessions of active rTMS over several weeks. Researchers …

This study tests whether low doses of psilocybin, the active ingredient in magic mushrooms, can reduce pain in people with fibromyalgia. Thirty-five adults will receive a placebo and two different low doses on separate days. Researchers will measure pain tolerance and self-report…

This study is testing a full-body suit that delivers mild electrical pulses to muscles. The goal is to see if it safely reduces spasticity, overactive reflexes, and pain in people with neurological conditions like multiple sclerosis or fibromyalgia. Fifteen adults will try both t…

This study tests whether adding shiatsu—a gentle Japanese bodywork therapy—to standard medical care can improve quality of life for children aged 10 to 18 with chronic non-inflammatory pain. About 40 participants will receive one 30-minute shiatsu session per week for six weeks a…

This study tests whether a gentle hands-on treatment called osteopathic manual therapy can reduce jaw pain and improve jaw function in people with fibromyalgia. About 114 adults with both conditions will receive either real or sham therapy. Researchers will measure pain, jaw move…

This study follows 105 adults with chronic pain, nerve damage, or slow wound healing from cancer treatments. They receive ozone therapy as an add-on to their usual care. Researchers track changes in quality of life, anxiety, and depression to see if ozone therapy helps.

This study evaluates a questionnaire called the Emotional Allodynia Questionnaire (AEQ), which measures how people with fibromyalgia react emotionally to everyday social cues. Researchers want to see if the tool can reliably identify fibromyalgia and tell it apart from other type…

This study asks 200 adults with chronic pain about their preferences between pain relief and common side effects like drowsiness, nausea, or addiction risk. Participants rate how much each side effect bothers them compared to the benefit of pain relief. The goal is to help doctor…

This study tests whether a special band-aid (called the A-Band) and a smartwatch can measure pain in women with chronic pain using AI. About 115 women with chronic pain and healthy women will wear the devices for a week and report their pain levels. The goal is to see if the devi…

This study will look at the medical records of 15,000 people with chronic pain to see how well different treatments, like spinal cord stimulation, worked for them. The goal is to learn which approaches provide the best pain relief. No new treatments are being tested; instead, res…

This study uses brain scans (fMRI) and sensory tests to explore how different types of chronic pain affect the brains of children and teens aged 10-17. Researchers hope to find shared and unique brain patterns across conditions like migraines, fibromyalgia, and abdominal pain. Th…

This study looks at how mindfulness meditation and self-hypnosis work in the brains of adults aged 60 and older who have had chronic pain for at least 3 months. Participants will be randomly assigned to mindfulness, hypnosis, or story listening, and will undergo brain scans and E…

This study looks at how long-term opioid therapy changes brain and spinal cord activity in women with chronic pain. Researchers will compare brain scans of women with chronic pain and/or opioid use to healthy women. The goal is to find new ways to treat chronic pain without relyi…

This study uses a special PET scan to measure brain inflammation in people with fibromyalgia, chronic fatigue syndrome, multiple sclerosis, and healthy volunteers. Researchers want to see if those with pain and fatigue have higher levels of brain inflammation. The study does not …

This study compares two widely used drug classes—anti-convulsants and anti-depressants—for treating chronic pain in 450 real-world patients. Unlike typical trials that exclude many patients, this one includes people with other health issues to get results that apply to more peopl…

This study looks at 600 teens and young adults (ages 14-26) with conditions like juvenile arthritis, fibromyalgia, or past surgeries to understand why some develop long-lasting pain while others don't. Researchers will examine pain sensitivity, immune markers, and social factors …

This study explores how dopamine, a brain chemical linked to motivation, influences chronic pain. Ten adults with chronic pain will receive two dopamine-boosting drugs (methylphenidate and carbidopa-levodopa) or a placebo, then undergo brain scans to measure changes in key pain-r…

This study investigates how colored light affects pain by scanning the brains of 60 people—half with chronic musculoskeletal pain (like fibromyalgia) and half healthy. Participants will view different light patterns while their brain activity is measured, and some will also recei…

This study looks at whether a type of IV line called a midline catheter can be used safely and effectively for repeated lidocaine infusions in an outpatient clinic. About 500 adults with chronic pain will receive ten lidocaine infusions through a midline catheter. Researchers wil…

This study looks at how pain is processed in people with fibromyalgia and rheumatoid arthritis, two conditions that cause long-term pain. Researchers will measure pressure pain thresholds in 150 adults to compare pain mechanisms. The goal is to better understand the differences a…

This study looks at why exercise often makes pain and fatigue worse for people with chronic widespread pain or fibromyalgia. Researchers will test if applying a mild electrical current to the brain (tDCS) during exercise can change how pain-related genes work. 120 participants (6…

This study looks at whether forward head posture (a common issue) is linked to worse fibromyalgia symptoms. Researchers will measure the angle of the neck in 134 adults with fibromyalgia and compare it to their symptom severity using a questionnaire. The goal is to better underst…

This study looks at two proteins in the blood—S100B and BDNF—to see if they are linked to pain sensitivity and poor sleep in people with fibromyalgia. Researchers will compare 60 women with fibromyalgia to healthy women. The goal is to better understand what causes fibromyalgia s…

This study aims to improve how doctors diagnose and treat chronic muscle and joint pain by using simple questionnaires and pain sensitivity tests. Researchers will study 250 adults with conditions like osteoarthritis, fibromyalgia, chronic low back pain, or inflammatory arthritis…

This observational study is working to create a more objective way to measure pain in children with juvenile idiopathic arthritis, lupus, or fibromyalgia. Researchers will follow 90 participants for one year, collecting data during regular clinic visits. The goal is to develop a …

This study aims to create a large e-cohort of 5,000 chronic pain patients using a smartphone app called eDOL. The app lets patients report their pain, treatments, and daily life, while doctors can monitor them through a web platform. The goal is to better understand chronic pain …

This study looks at how brain networks synchronize in people with fibromyalgia, a condition causing widespread pain. Researchers will use EEG and fMRI to measure brain activity and test a gentle brain stimulation technique called HD-tDCS. The goal is to understand pain processing…

This study is collecting information from 200 people with cerebral palsy, multiple sclerosis, stroke, fibromyalgia, or similar nerve disorders to see how the EXOPULSE Suit affects their balance and risk of falling over time. Participants will be followed routinely, and researcher…

This study is observing 120 people with chronic pain to learn how to design a more effective pain clinic. Researchers will track pain levels, medication use, and overall well-being. The goal is to understand what patients need, not to test a new treatment.

This study tests whether spinal cord stimulation can create artificial sensations, like tingling, and how changing stimulation settings affects those sensations. Ten adults with chronic pain who are already scheduled for spinal cord stimulation will participate. The goal is to be…

This research study collects health information from 10,000 people with brain inflammation conditions like Long COVID, ME/CFS, and autoimmune diseases. Participants use a smartphone app to share symptoms, health history, and wearable data. The goal is to find disease subtypes and…

This study looks at whether people with HIV have chronic pain because their bodies don't make enough natural painkillers (opioid peptides). Researchers will test pain sensitivity in 200 adults (with and without HIV) using heat, touch, and pressure. The goal is to understand the c…

This study looks at whether mothers who have fibromyalgia and also care for a child with ADHD experience a higher disease burden. Researchers will compare 50 such mothers with 50 mothers who have fibromyalgia but whose children have no psychiatric conditions. The goal is to under…

This study aims to find out if spinal cord stimulation (SCS) truly reduces pain or if the effect is just due to patients' expectations. Twenty-five adults with chronic pain who already have an SCS implant will take part in four test sessions. During each session, the stimulator w…

This study looks at whether taking prescription opioids for chronic pain changes the brain structure of adults aged 65 and older. Researchers will use MRI scans to measure brain changes over time. The goal is to understand the risks of long-term opioid use on brain health.

This study looks at how chronic knee pain and fibromyalgia change the way nerves talk to muscles. Researchers will test pain sensitivity, muscle activity, and physical function in 135 adults. No treatment is given—the goal is to better understand the role of the central nervous s…

This study tests a new way to adjust spinal cord stimulation in 15 adults with chronic pain who already have spinal cord implants. Researchers will use electrical recordings called ECAPs to find the best stimulation settings. The goal is to see if this approach is feasible and ac…

This study looks at whether keeping a regular sleep schedule can improve heart and metabolic health in healthy adults aged 18-40, and also in people with chronic pain. Over 12 weeks, researchers will measure changes in sleep timing, blood pressure, heart rate, and other health ma…

This study tests whether people with fibromyalgia can learn to control their own brain activity using real-time brain scans (fMRI) to reduce pain. Participants will either receive cognitive behavioral therapy or fibromyalgia education over 8 weeks. The goal is to see if self-regu…

This study looks at how mood, brain inflammation, and exercise are linked to pain in 60 veterans with fibromyalgia. Participants will do a 6-week supervised walking program and complete pain, mood, and blood tests. The goal is to understand these connections and design a better e…

This study explores whether a sham (fake) neurofeedback system in virtual reality can change brain activity related to attention. About 35 adults with rumination or chronic pain will undergo EEG recordings while experiencing positive, negative, or no feedback. The goal is to see …

This study checks if a computer algorithm can correctly identify the cause of chronic pain, just like a pain specialist would. About 200 adults with pain lasting at least one month will have their symptoms and history analyzed by both the algorithm and a doctor. The goal is to se…

This study uses a smartphone app called SOMA to track daily mood, pain, and activity in 800 people with acute or chronic pain over four months. The goal is to find patterns that predict whether acute pain becomes chronic, or if chronic pain flares up. A smaller group will also ha…

This study looks at how central sensitization—a heightened pain response common in fibromyalgia—might be linked to cognitive problems like memory and concentration issues. Researchers will assess 100 adults with fibromyalgia using questionnaires and cognitive tests. The goal is t…

This study aims to find out how common small fiber neuropathy is in people with fibromyalgia compared to those with other chronic pain conditions and healthy volunteers. Researchers will use skin biopsies and other tests to check for nerve damage. The goal is to better understand…

This study looks at how central sensitization—a heightened pain response in the brain—relates to balance problems in people with fibromyalgia. Researchers will compare 75 fibromyalgia patients to healthy individuals using pain tests and a special balance device. The goal is to un…

This study aims to objectively measure how internet-based exposure-based cognitive behavioral therapy (Exp-CBT) affects pain regulation in people with fibromyalgia. About 45 participants will undergo pain tests before and after 10 weeks of online therapy to see if their pain thre…