Fibromyalgia

This study tested whether adding Dermabond (a medical glue) to stitches helps keep spinal cord stimulator leads from moving after placement. 57 adults with chronic pain had their leads secured either with stitches alone or with stitches plus glue. The main goal was to measure how…

This study tested whether breathing pure oxygen in a pressurized chamber (hyperbaric oxygen therapy) works better than standard medications (Cymbalta or Lyrica) for fibromyalgia triggered by emotional trauma. 48 adults completed the trial, and researchers measured symptom improve…

This study tested two tools to help older adults (65+) on long-term opioid therapy use painkillers more safely. The PainTracker tool helps doctors focus on improving daily function and mental health, while the Opioid Misuse Measure screens for risky opioid use. Researchers studie…

This study tests four virtual coaching sessions to help veterans with chronic pain use their own cannabis products more effectively. Participants will learn strategies to manage pain and related symptoms. The goal is to see if this coaching improves pain relief and satisfaction.

This study tested a 16-session web-based resistance training program for people with fibromyalgia. Researchers measured balance, muscle performance, and symptoms in 13 adults. The goal was to see if a home-based exercise program could improve physical function and ease fibromyalg…

This study tested a 24-session program for 100 adults with fibromyalgia. The program brings together nurses, doctors, physiotherapists, nutritionists, and mental health experts to teach self-management skills. Researchers measured quality of life, pain impact, and mood over 12 mo…

This study looked at whether adding a gentle electrical nerve stimulation (TENS) to cognitive behavior therapy (CBT) and standard medicines could reduce pain and improve quality of life in 60 postmenopausal women with fibromyalgia. Participants were split into three groups: one r…

This study tested whether sound therapy using weighted tuning forks, combined with relaxation, could reduce pain in women with fibromyalgia. Forty women aged 30 to 60 took part, attending three weekly sessions. Researchers compared pain levels before and after sessions between th…

This study looked at how the brain processes pain in people with fibromyalgia compared to healthy individuals. Researchers tested whether a non-invasive procedure called transcranial magnetic stimulation (TMS), which uses magnetic pulses to stimulate the brain, could reduce pain …

This study tested whether tailoring magnetic brain stimulation to each person's brain signals can better relieve chronic pain. Researchers measured brain activity before treatment to customize the stimulation. 90 adults with chronic pain took part. The goal was to see if this per…

This study tested whether a non-invasive, FDA-approved device called cranial electrical stimulation (CES) can reduce chronic pain in veterans with fibromyalgia. Fifty veterans received either real CES or a placebo treatment for several weeks. Researchers used brain scans and pain…

This study tested whether doing exercise in a virtual reality headset can improve quality of life, thinking, and mood in people with fibromyalgia. Thirty adults with fibromyalgia took part in a crossover trial where everyone tried both virtual reality exercise and regular exercis…

This study looked at whether classical massage can reduce pain and improve daily function in people with myofascial pain syndrome, a condition that causes muscle knots and radiating pain. Sixty adults aged 30–50 with active trigger points in the upper back took part. Researchers …

This study looked at whether aerobic dance exercises can improve symptoms and quality of life in women with fibromyalgia. Forty-four women were split into two groups: one did aerobic dance sessions led by a physiotherapist, and the other did standard postural exercises. Researche…

This study tested whether a daily probiotic supplement could reduce pain, fatigue, and cognitive issues in women with fibromyalgia. 97 participants took either a multi-strain probiotic or a placebo for 12 weeks. Researchers measured changes in pain, sleep, mood, and quality of li…

This study tested whether stimulating a nerve in the ear (taVNS) can help people with fibromyalgia feel better and exercise more. 90 adults with fibromyalgia were split into three groups: one-sided stimulation, both ears, or just a home exercise program. Over two weeks, researche…

This study tested whether a digital sleep therapy program called Sleepio can improve quality of life, sleep, and thinking in people with fibromyalgia. 80 participants were randomly assigned to use Sleepio or receive standard sleep advice. Researchers measured changes in symptoms …

This study tested whether a short motivational interview combined with self-management techniques could help Hungarian teens aged 12-18 who have had chronic pain for at least 3 months. The program included a 30-minute in-person session plus two follow-up phone calls. Researchers …

This study tested whether breathing pure oxygen in a pressurized chamber (hyperbaric oxygen therapy) could reduce pain and improve quality of life in people with fibromyalgia, compared to standard medications like Cymbalta or Lyrica. Seventy-six adults with fibromyalgia and a his…

This study from Harvard University tested whether mindfully noticing changes in pain throughout the day can help people with chronic pain feel more in control and reduce pain intensity. 300 adults with chronic pain for at least six months were split into groups that either paid c…

This completed study tested whether hyperbaric oxygen therapy (HBOT) combined with creative art psychotherapy can help women with fibromyalgia who have a history of psychological trauma. Thirty women received 60 sessions of HBOT plus psychotherapy. Researchers measured pain sensi…

This study tested whether personalized health coaching can improve daily life for Veterans suffering from long-term pain and related symptoms. Researchers enrolled 260 Veterans with chronic multisymptom illness (like fibromyalgia) and measured changes in pain and disability. The …

This study tested a smartphone app and website called iCanCope with Pain, designed to help teens and young adults (ages 15-25) manage chronic pain. The app lets users track pain, sleep, mood, and activity, set goals, and learn coping strategies. The goal was to see if the program…

This completed study looked at how well radiofrequency ablation (a procedure that uses heat to calm pain nerves) works for people with chronic pain. 298 participants were treated with a Boston Scientific device and then rated their improvement. The goal was to see real-world resu…

This study tested whether a slow, gentle back massage can help women with fibromyalgia feel less pain and fatigue. 48 women took part, receiving 30-minute massages three times a week. The goal was to see if this simple, drug-free approach could improve daily comfort.

This study tested two at-home digital programs for chronic pain: a virtual reality (VR) program and a self-guided online course. 330 adults with chronic pain used one of the programs for 8 weeks. Researchers measured changes in pain intensity and how pain affected daily life. The…

This study looked at whether indoor physical activity can improve symptoms in people with both fibromyalgia and irritable bowel syndrome (IBS). Researchers measured changes in gut and pain symptoms, intestinal health, and psychological well-being in 165 participants. The goal was…

This study tested a 10-week education program designed to help Korean Americans with chronic pain. The program taught coping strategies and pain management skills in group sessions held at community centers. Researchers wanted to see if the program was feasible and acceptable, an…

This study tested two treatments for vestibulodynia, a chronic pain condition affecting the vulvar area. 209 women received either a lidocaine/estradiol cream, the antidepressant nortriptyline, both, or a placebo. The goal was to see which approach best reduces pain and improves …

This study tested a brief, three-session program for people with chronic pain and a history of stressful or traumatic experiences. The goal was to see if the program was practical and helpful. Fifty adults participated, and the study focused on whether people would join, complete…

This study tested a phone-based version of the Walk With Ease program for 267 adults with arthritis, gout, fibromyalgia, rheumatoid arthritis, osteoarthritis, or lupus. Participants followed a 6-week walking program delivered by phone, and researchers measured changes in pain, ph…

This study tested whether adding a gentle manual therapy called strain counterstrain to standard physiotherapy helps women with fibromyalgia feel better. 105 women were split into three groups: one got standard care, another got standard care plus the therapy, and a control group…

This study tested an 8-week online mindfulness-based stress reduction program in 94 adults with fibromyalgia. Participants were randomly assigned to the online program or usual care. The goal was to see if the program could reduce pain catastrophizing and improve daily function.

This study tested a self-management program for jaw muscle pain in 107 adults with fibromyalgia. The program included online sessions on pain education, jaw exercises, and self-massage. Researchers measured changes in quality of life, pain, and fear of movement over 12 months. Th…

This study tested whether different types of sounds (natural, city, broadband, or silence) can help improve mood, stress, and anxiety in people with fibromyalgia. 72 adults with fibromyalgia listened to each sound for 20 minutes during four weekly visits. Researchers measured cha…

This study looked at how intravenous lidocaine affects sleep and quality of life in 51 people with fibromyalgia who still had pain and sleep problems despite other treatments. Researchers measured pain, sleep quality, and overall impact of the condition. The goal was to see if th…

This study looked at whether an 8-week foot exercise program could help people with fibromyalgia who have foot pain. 27 adults with fibromyalgia took part. The program focused on strengthening the small muscles in the feet. Researchers measured changes in foot pain, function, and…

This study tested whether a virtual yoga program could help people with chronic pain. 94 participants with pain lasting over 6 months took part in 8 weeks of remote yoga classes and daily 30-minute video-guided practice. Researchers measured how feasible the program was and wheth…

This completed pilot study tested whether a smartphone app teaching mindfulness could help people with fibromyalgia. Fifty-four adults used the app daily for pain tracking and weekly for mindfulness lessons, while a control group only tracked symptoms. The goal was to see if the …

This study looked at whether an antidepressant, physical therapy, or a combination of both can help people with chronic low back pain who also struggle with negative feelings. About 308 adults aged 18-75 with pain lasting over 6 months took part. The goal was to see if these trea…

This study tested whether adding home-based posture exercises to regular medication could improve pain and mobility in 55 adults with fibromyalgia. Participants did exercises at home while continuing their usual drugs. Researchers measured pain threshold, spinal flexibility, anxi…

This study tested two types of telehealth programs for people with chronic pain: an online self-guided program and live sessions led by a health coach via phone or video. Over 2,300 adults from four healthcare systems took part. The goal was to see if these programs could help re…

This study tested a smartphone app designed to help people with fibromyalgia manage their condition. Researchers wanted to see if the app was easy to use and helpful. The study included 36 adults with fibromyalgia who used the app to track their symptoms and learn coping strategi…

This study tested a non-invasive device that sends mild electrical pulses to the ear to stimulate the vagus nerve, which helps control pain and stress. Thirty adults with fibromyalgia received either real or sham stimulation for 30 minutes daily, five days a week, over four weeks…

This study tested whether an ultrasound-guided nerve block injection (stellate ganglion block) could help people with fibromyalgia who still have symptoms despite taking duloxetine. 68 adults received either the active injection or a sham (fake) injection, and researchers measure…

This pilot study tested an oral cannabinoid oil (CBD with a small amount of THC) in 51 adults with chronic pain. The goal was to see if it's practical to run a larger trial and to gather early data on pain relief and safety. Participants took the oil daily for up to 12 weeks, and…

This study tested whether a non-invasive brain stimulation technique called tDCS can reduce pain in women with fibromyalgia. 100 women received either real or sham (fake) stimulation to see if the placebo effect plays a role. The goal is to find out who might benefit most from th…

This completed study tested whether a non-invasive brain stimulation technique called tDCS can reduce pain and improve daily function in 100 women with fibromyalgia. Researchers also looked at how a person's tendency to respond to placebo might affect results. Participants receiv…

This study tested a web app called Rose that provides hypnosis audio recordings for people with chronic pain. 100 adults with chronic low back pain or other chronic pain used the app for 8 weeks. The researchers measured how often people used it, their satisfaction, and changes i…

This study looked at whether 8 weeks of strength training could improve balance, muscle performance, and symptoms in 57 adults with fibromyalgia. Participants did 16 sessions of 50-minute strength exercises twice a week. Researchers measured balance, jumping ability, and upper bo…

This study looked at a voluntary program to help people with chronic pain slowly lower their opioid medications. 51 adults who wanted to reduce their opioid dose worked with their doctor over 4 months using a personalized tapering plan and a self-help book. The main goal was to s…

This study tested whether a toolkit called Pain at Work (PAW) can help employees with chronic pain manage their symptoms and stay productive. Around 380 workers from different workplaces in England took part, with some using the toolkit plus support calls and others receiving usu…

This study tested whether adding a gentle brain stimulation technique called rTMS to standard exercise therapy could reduce pain in people with fibromyalgia. Forty-two adults with long-term pain took part, receiving either real or fake rTMS alongside exercise for 14 weeks. Resear…

This study tested whether combining a gentle brain stimulation technique called tDCS with aerobic exercise could improve the body's natural pain control system in people with fibromyalgia. 116 adults with fibromyalgia received either active or sham tDCS along with exercise or a c…

This study tested whether a mindfulness-based group therapy program, originally developed in Canada, could work for French teenagers aged 12-17 with chronic pain. The main goal was to see if teens would attend at least 6 out of 8 sessions. Researchers also looked at effects on pa…

This study tested whether Pilates or core stability exercises better ease fibromyalgia symptoms like pain and balance. Thirty women aged 35-65 with fibromyalgia took part. Researchers used objective tests (pain sensitivity, balance) instead of just questionnaires to compare the t…

This study tested whether relaxation therapy can reduce chronic pain and improve daily life in people with fibromyalgia. Eighty adults with fibromyalgia were randomly assigned to either active relaxation sessions with a therapist or to relax alone in a quiet room (placebo) for 12…

This study tested whether different types of sounds—like birdsong, traffic noise, or white noise—can reduce pain in people with fibromyalgia, a condition causing widespread pain. 88 adults with fibromyalgia listened to four different sound environments for 20 minutes each, one we…

This study tested whether adding virtual reality to standard physiotherapy could help teenagers with chronic musculoskeletal pain. 34 teens aged 10-17 took part in up to 8 sessions over 6-12 weeks. The goal was to see if VR was practical and enjoyable, and whether it could improv…

This study compared two antidepressant medications, duloxetine and desipramine, to see which one reduces pain better in people with chronic pain. About 86 adults with pain lasting more than 3 months took one of the two drugs for six months. The main goal was to see how many peopl…

This study tested whether a daily pill called ASP8062 can reduce pain and improve daily life for people with fibromyalgia. 183 adults took either the drug or a placebo for 8 weeks. Researchers measured pain scores, side effects, and overall well-being. The trial is now complete, …

This study looked at whether adding a TENS device (which uses mild electrical pulses) to regular physical therapy helps reduce pain during movement in people with fibromyalgia. Over 450 adults with fibromyalgia took part. Researchers measured pain levels and other symptoms to see…

This study tested a mind-body program called GetActive for adults with chronic pain. The program combines relaxation techniques, coping skills, and physical activity (with or without a Fitbit). 82 participants completed the program, and researchers measured satisfaction, safety, …

This study looked at whether offering telehealth sessions of massage, yoga, chiropractic, or physical therapy could help adults with chronic pain reduce their opioid use and feel better. Twenty-one people participated, and researchers tracked changes in pain intensity, pain inter…

This study tested a 12-week home exercise program for women with fibromyalgia. Sixty participants were randomly assigned to exercise or a control group. Researchers measured changes in pain, fatigue, quality of life, and mood. The goal was to see if a structured, at-home routine …

This study tested a 90-minute pain management class for 110 youth aged 10-18 with chronic pain. The class teaches pain science and self-regulation skills like relaxation and cognitive techniques. Researchers checked if the class was acceptable and helpful by surveying participant…

This study tested whether cognitive behavioral therapy for insomnia (CBT-I) can improve sleep and reduce pain in women with fibromyalgia. 131 women with both conditions received either CBT-I or sleep hygiene education. Researchers measured sleep quality, pain sensitivity, and bra…

This study tested a new approach for chronic low-back pain and fibromyalgia in 48 adults. Participants received pain education plus propranolol (a blood pressure drug) to help the brain 'relearn' and reduce pain. The goal was to see if the treatment is feasible and acceptable, an…

This study tested whether phone calls from a nurse could help people with fibromyalgia feel less pain and be more active. 44 adults were split into two groups: one got standard care, the other also received an educational booklet and three phone calls over 4 weeks covering exerci…

This pilot study tested a non-drug treatment called myoActivation for chronic pain in 41 marginalized people. The therapy uses a structured assessment and needling to release muscle tension. Researchers measured pain, function, and quality of life over 24 weeks to see if it helps…

This study tested whether giving adults with chronic pain a user guide and weekly prompts helps them use an online pain-management resource more effectively. 99 participants were split into two groups: one got the guide and prompts, the other just the online resource. Researchers…

This study tested whether a special suit called EXOPULSE Mollii can help adults with fibromyalgia feel less pain, fatigue, and depression. Twenty-eight participants wore either the active suit or a sham (fake) suit for two weeks, then had a washout period. After that, everyone co…

This study looked at whether 6 weeks of osteopathic treatment (gentle hands-on manipulation) could reduce pain in people with fibromyalgia. 101 adults with long-term fibromyalgia took part, comparing real osteopathy sessions to fake ones. The main goal was to track pain levels we…

This completed study tested whether adding cognitive behavior therapy (CBT) to standard physiotherapy helps adults with fibromyalgia feel less pain and have a better quality of life. 66 people took part, with one group doing gentle exercises and the other doing exercises plus CBT…

This study aims to understand why people experience pain differently and whether the body's natural ability to manage pain can be improved through training, similar to athletic performance. Researchers will enroll 180 adults, including those with widespread muscle pain and those …

This study looked at how three psychological treatments—cognitive therapy, mindfulness meditation, and behavioral activation—might help adults with chronic pain reduce their use of opioid medications. Researchers enrolled 91 people with chronic pain who were at risk of opioid mis…

This study compared 80 women with and without fibromyalgia to measure muscle strength, muscle thickness, vitamin D levels, and sleep quality. Researchers used advanced tools like isokinetic dynamometers and ultrasound to find differences between the groups. The goal was to better…

This study follows 87 women who had chronic low back pain 13 years ago to see how their pain, daily activities, and ability to work have changed. Researchers are looking for patterns that might predict who will improve or worsen over time. The goal is to better understand the lon…

This study talked to 50 adults with long-term (non-cancer) pain and their healthcare providers to learn about their experiences managing pain in primary care. The goal was to use this information to create a decision aid tool that helps patients and doctors make informed choices …

This study gathered information from 73 adults with chronic pain who were already using or planning to use an approved medical device (like a spinal cord stimulator) for their pain. Researchers asked participants to report their pain levels on a 0-10 scale and other outcomes duri…

This completed study looked at 393 adults aged 65 and older with chronic pain to see how frailty relates to the type and location of pain, as well as nutritional risk. Researchers measured frailty using standard criteria and assessed pain intensity and type. The goal is to help d…

This study looked at whether the weekly performance of a favorite NFL team affects chronic pain in avid football fans. Thirty-two adults with chronic pain completed weekly surveys during the football season, rating their pain, mood, and pain-related thoughts. The goal was to see …

This completed pilot study looked at how lifestyle factors like diet, physical activity, sleep, stress, smoking, and alcohol use relate to pain sensitivity in 20 women with fibromyalgia. Participants wore a Fitbit, logged food, completed questionnaires, and had pain sensitivity t…

This study looked at whether levels of certain minerals (like selenium, magnesium, and zinc) in the blood are different in women with fibromyalgia compared to healthy women. It also checked if those mineral levels are linked to how severe the disease is, or to anxiety and depress…

This completed study examined whether fibromyalgia, a condition causing widespread pain, is linked to changes in eye blood vessels. Researchers compared 80 people with and without fibromyalgia using eye scans and symptom questionnaires. The goal was to see if nerve system problem…

This study looked at how having fibromyalgia changes body measurements and sleep patterns in people with obstructive sleep apnea. Researchers measured neck, waist, and hip sizes, and used sleep tests and ultrasound to compare 77 participants. The goal was to better understand the…

This study looked at 65 people with fibromyalgia to figure out what kind of pain they have—nerve pain, tissue pain, or a mixed type. Researchers used a special checklist and simple tests like brushing the skin or pressing with a tool. The goal is to help doctors choose better tre…

This study looked at how spinal cord stimulation (SCS) affects pain processing in 34 people with chronic pain. Participants already had an SCS device as part of their care. Researchers tested different stimulation patterns (burst, kHz, tonic, and sham) to see how they changed the…

This study looked at whether people with fibromyalgia have early, hidden changes in heart function. Researchers used a special ultrasound technique called Global Longitudinal Strain (GLS) to measure heart muscle movement in 59 fibromyalgia patients and 59 healthy volunteers. The …

This study looked at 420 people aged 80 and older to find out how many have fibromyalgia, a condition that causes widespread pain and fatigue. Researchers used standard medical criteria to diagnose fibromyalgia and also checked participants' memory, thinking, and overall health. …

This completed study looked at how psychological resilience and body image relate to pain in people with rheumatoid arthritis or fibromyalgia, compared to healthy volunteers. Researchers measured these factors using questionnaires in 124 adults. The goal was to better understand …

This completed study looked at 128 women to see if those with fibromyalgia also have more chronic pelvic pain and pelvic floor problems. Researchers used pain questionnaires to compare the two groups. The goal was to better understand how these conditions might be related, not to…

This completed study looked at blood samples from 66 women to find differences in small molecules (metabolites) between those with fibromyalgia, those with both fibromyalgia and possible sarcopenia (muscle loss), and healthy women. The goal was to identify potential biomarkers th…

This completed study from Turkey examined vitamin B12 and folic acid levels in 104 fibromyalgia patients before and after they started antiepileptic treatment. Researchers wanted to see if these drugs, already known to lower B12 and folate in epilepsy patients, have the same effe…

This completed study looked at 164 women with and without fibromyalgia to see if certain autoantibodies are linked to more severe symptoms. Researchers compared patients with high and low antibody levels, and healthy controls, using questionnaires, blood tests, skin biopsies, and…

This study aimed to uncover what factors most affect functional capacity—like walking, standing, and daily tasks—in people with fibromyalgia. Researchers assessed 42 adults using physical tests, pain and fatigue scales, posture analysis, sleep quality, and psychological questionn…

This completed study from the University of Valencia looked at 133 adults with chronic pain to see if jaw (temporomandibular) pain is linked to pelvic pain. Participants filled out questionnaires about their pain, emotions, and sensitivity. The goal was to understand why these pa…

This study followed 2,365 adults from urban areas of Chile for 12 months to learn more about chronic pain and its effects. Researchers looked at how chronic pain relates to mental health issues like depression and anxiety, as well as work stress and daily functioning. The goal wa…

This study looked at how many women with fibromyalgia at a pain clinic might have iron deficiency. 81 women completed a questionnaire about symptoms like heavy periods and past iron issues. The goal was to see if iron deficiency is common and if treating it could help their pain.

This study looked at how a special exercise approach called BETY affects people with rheumatic diseases (like arthritis) who have chronic pain. Researchers reviewed past records of 300 participants to see if BETY improved their physical function, mood, and quality of life compare…

This study looked at 173 adults with fibromyalgia to see if doomscrolling—constantly reading negative news online—and social media addiction are linked to worse symptoms. Participants completed surveys about their social media habits, fear of missing out, and fibromyalgia-related…

This study tested whether problems with brain cells that control movement cause fatigue in fibromyalgia. Researchers compared 37 women (some with fibromyalgia, some healthy) by measuring muscle signals during foot exercises, including when they were cheered on. The goal was to se…

This study looks at how the brains of fibromyalgia patients and their acupuncturists work together during electroacupuncture treatment. Using special MRI scans that record both people at once, researchers hope to see if matching brain activity leads to better pain relief. The goa…

This study surveyed 116 adults with chronic pain at a rehabilitation clinic to understand how their pain beliefs, spiritual well-being, and attitudes toward complementary and alternative medicine are related. Participants filled out several questionnaires about their pain, mood, …

This study looked at how different types of touch, like those used in massage, affect pain in people with fibromyalgia compared to healthy volunteers. Researchers measured pain levels, touch pleasantness, and other factors like mood and trauma history. The goal was to better unde…

This study looked at whether a Turkish questionnaire about posture habits and awareness is a valid and reliable tool for people with fibromyalgia. One hundred patients completed the scale along with other surveys. The goal was to see if the scale accurately measures what it is su…

This study looked at how focusing on negative thoughts (rumination) versus distracting yourself affects your mood after physical activity in people with fibromyalgia. 47 adults with fibromyalgia took part. Researchers gave them instructions to either ruminate on their muscle tens…

This study looked at how repetitive negative thinking (rumination) affects the emotional and mental symptoms of fibromyalgia. Researchers studied 107 adults with fibromyalgia using questionnaires. The goal was to understand if rumination plays a role in depression and anxiety oft…

This study looked at how stress changes gene activity in women with chronic widespread pain (fibromyalgia). Researchers compared 84 women with and without the condition, using mental stress tests and relaxation breathing. They measured changes in DNA methylation, a process that c…