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Ear nerve zaps show promise for fibromyalgia pain and fatigue

NCT ID NCT07577102

Symptom relief Sponsor: Istanbul Gelisim University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether stimulating a nerve in the ear (taVNS) can help people with fibromyalgia feel better and exercise more. 90 adults with fibromyalgia were split into three groups: one-sided stimulation, both ears, or just a home exercise program. Over two weeks, researchers measured symptoms like pain, anxiety, sleep, and how many reps they could do. The goal was to see if adding nerve stimulation to exercise gives extra benefits.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
transcutaneous auricular vagus nerve stimulation (taVNS) device
What this could lead to
If it works, this could point toward a non-drug way to ease fibromyalgia symptoms and improve exercise ability.
What could go wrong
This is a small, short-term study (2 weeks, 90 people) with no blinding, so results may not be reliable or last long-term.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

90 people

The number who actually took part.

Started

Jan 2022

Finished

Jun 2023

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 45 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Were between 18 and 45 years of age * Were diagnosed with fibromyalgia according to the 2016 ACR diagnostic criteria \-- Stable clinical condition * Ability to understand and follow study procedures * Willingness to participate and provide informed consent Exclusion Criteria: * A history of malignancy * Cardiopulmonary diseases contraindicating exercise * Limb loss * Ear infections and implants, implanted electronic devices * Systemic diseases (hematological, endocrine, rheumatological, renal, cardiovascular, gastrointestinal, neurological, or autoimmune diseases) * Active infection * Surgery or major trauma within the previous 6 months * Postmenopausal status * Pregnancy or lactation

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Conditions

The condition(s) this trial relates to.

fibromyalgia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Fibromyalgia syndrome

Contacts and locations

Locations

  • Darülaceze Medical Center

    Istanbul, Turkey (Türkiye)

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