Could fibromyalgia drugs drain your B12?

NCT ID NCT07013305

Completed Knowledge-focused Sponsor: Gaziosmanpasa Research and Education Hospital Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed study from Turkey examined vitamin B12 and folic acid levels in 104 fibromyalgia patients before and after they started antiepileptic treatment. Researchers wanted to see if these drugs, already known to lower B12 and folate in epilepsy patients, have the same effect in fibromyalgia. The study is retrospective, meaning it looked at past medical records, so it can suggest a link but not prove it.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: antiepileptic drugs (anticonvulsants)
What this could lead to: If it shows that antiepileptics lower B12 or folate, it could point to a need for vitamin monitoring or supplementation in fibromyalgia patients.
What could go wrong: This is a small, retrospective study that only looks back at existing records. It cannot prove cause and effect, and results may not apply to all patients.

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Conditions

The condition(s) this trial relates to.

fibromyalgia Folic Acid Deficiency folic acid deficiency anemia vitamin B12 deficiency vitamin D deficiency

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

FIBROMYALGIA (FM) FOLIC ACID DEFICIENCY VITAMIN B 12 DEFICIENCY

Contacts and locations

Locations

Gaziosmanpasa Research and Education Hospital

Istanbul, Gaziosmanpasa, 34255, Turkey (Türkiye)

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