Stress and pain: scientists uncover hidden gene changes in fibromyalgia

NCT ID NCT06475859

Completed Knowledge-focused Sponsor: Vrije Universiteit Brussel Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study looked at how stress changes gene activity in women with chronic widespread pain (fibromyalgia). Researchers compared 84 women with and without the condition, using mental stress tests and relaxation breathing. They measured changes in DNA methylation, a process that can turn genes on or off. The goal was to understand why stress makes pain worse, which could lead to better treatments in the future.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this research could point toward new ways to understand and eventually treat stress intolerance in chronic pain conditions.
What could go wrong: This is an observational study with only 84 participants. It looks at biological markers, not a treatment, so it may not lead directly to new therapies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Chronic Pain fibromyalgia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC WIDESPREAD PAIN

Contacts and locations

Locations

Vrije Universiteit Brussel - UZ Brussel

Brussels, Brussels Capital, 1050, Belgium

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