New combo therapy aims to wean surgery patients off opioids faster

NCT ID NCT06027099

Recruiting now Disease control Sponsor: Stanford University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether counseling plus a muscle relaxant (tizanidine) can help adults who have used opioids for a long time reduce their pain medication after elective surgery. About 375 participants will be randomly assigned to one of three groups: the combo treatment, counseling plus a placebo, or standard care. The goal is to see if the intervention helps people return to their pre-surgery opioid level or stop opioids sooner, while also improving pain recovery and reducing misuse over 12 months.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for BACK PAIN are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

Back Pain Chronic Pain chronic pain syndrome Neck Pain opiate dependence opioid abuse

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BACK PAIN CHRONIC PAIN NECK PAIN OPIOID MISUSE

Contacts and locations

Show contact details

Study contacts

Contact

Email: •••••@•••••

Locations

Atrium Health Wake Forest Baptist Medical Center
RECRUITING

Winston-Salem, North Carolina, 27157, United States
Harvard University- Brigham and Women's Hospital
RECRUITING

Boston, Massachusetts, 02115, United States
Stanford University Medical Center
RECRUITING

Stanford, California, 94305, United States
University of Kansas Medical Center
RECRUITING

Kansas City, Kansas, 66103, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.