BACK PAIN

This study tests whether counseling plus a muscle relaxant (tizanidine) can help adults who have used opioids for a long time reduce their pain medication after elective surgery. About 375 participants will be randomly assigned to one of three groups: the combo treatment, counsel…

This study tests a synthetic bone graft material called MagnetOs Easypack Putty in people having spinal fusion surgery for back pain or spine instability. The putty is used alone to help bones fuse together. Researchers want to see if it works as well as or better than current tr…

This study tests whether a single nerve block injection (erector spinae plane block) can reduce persistent back pain in people with ankylosing spondylitis whose disease activity is already controlled by medication. Fifteen adults aged 18–65 will receive the injection and be monit…

This study compares two common injection treatments for chronic mid-back pain: the erector spinae plane (ESP) block and trigger point injection (TPI). About 76 adults with pain lasting at least three months will be randomly assigned to one treatment. Researchers will track pain l…

This study tests whether sports bras designed for full-busted women can reduce chronic pain in the neck, shoulders, arms, and back. Researchers will also look at how hormones, inflammation, and brain changes may contribute to this pain. About 140 women aged 18-60 will wear a spec…

This study tests whether a small device that sends mild electrical pulses through the skin (TENS) can quickly reduce acute low back pain in people visiting the emergency department. About 222 adults with recent back pain will receive either real TENS or a placebo device for 30 mi…

This study compares an 8-week mindfulness-based stress reduction (MBSR) course to standard care for working-age adults (18–64) with back pain lasting over 12 weeks. Half of the 120 participants will take the course, and all will be followed for 2 years. The goal is to see if mind…

This study tests whether a newer therapy called Pain Reprocessing Therapy (PRT) works better than standard Cognitive Behavioral Therapy (CBT) or usual care for veterans with chronic back or neck pain. About 360 veterans will be randomly assigned to one of three groups and complet…

This study tests whether dry needling—a technique where thin needles are inserted into muscles—can reduce pain and improve quality of life for people with chronic low back pain. Researchers will also check if the approach is practical and acceptable. The study includes 42 adults,…

This study tests whether cannabidiol (CBD), a non-intoxicating compound from cannabis, can reduce inflammation in the brain. Researchers will give CBD or a placebo to 80 adults with chronic low back pain, with or without mild-to-moderate depression. They will use brain scans to m…

This study is testing whether taking cannabis by mouth can safely reduce chronic back or neck pain and help people cut down on strong painkillers like opioids. About 157 adults with pain lasting at least 3 months will receive either cannabis or a placebo. The goal is to see if ca…

This early-stage study is testing whether an injection of Alocyte, made from cord blood plasma and cells, is safe for people with back pain caused by worn facet joints. About 15 adults will receive a low, medium, or high dose into the painful joint. Researchers will monitor for s…

This study tests whether adding shock wave therapy to core stability exercises reduces chronic back pain in female university students. 100 participants with non-specific back pain for over 3 months will be enrolled. The goal is to see if the combination improves pain, physical f…

This study tests whether a smartphone app called Medidux can help people who were admitted to the hospital with non-urgent issues like cough, back pain, or belly pain. About 417 adults will either use the app to track symptoms for 7 days after discharge or receive standard care. …

This study looks at how inhaled cannabis affects the brain in people with chronic low back pain. Researchers will use MRI scans to measure changes in brain blood flow and oxygen levels, and ask participants to rate their pain. The goal is to understand the brain mechanisms behind…

This study looks at how having other chronic conditions (like diabetes or heart disease) affects people with back or neck pain. Researchers will track 2,000 adults referred to hospital clinics in Denmark, measuring their quality of life, pain levels, and how their overall health …

This study looks at how stress changes the way opioid painkillers work in people with chronic back pain. Researchers will give participants oxycodone, a pain blocker, or a placebo in a lab setting to measure pain relief and drug liking. The goal is to understand why some people m…

This study aims to find out how many medical students at the University of the West Indies, Mona, have neck or low back pain, and whether a standardized exercise program can help. About 1,000 students will take part, with some doing the exercises and others not. The researchers w…