Can CBD cool brain inflammation and ease back pain and depression?
NCT ID NCT05066308
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether cannabidiol (CBD), a non-intoxicating compound from cannabis, can reduce inflammation in the brain. Researchers will give CBD or a placebo to 80 adults with chronic low back pain, with or without mild-to-moderate depression. They will use brain scans to measure changes in inflammation and see if symptoms improve.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- cannabidiol (CBD) oral solution
- What this could lead to
- If it works, this could point toward a new way to treat chronic back pain and depression by reducing brain inflammation.
- What could go wrong
- This is a small, early-stage trial. CBD may not reduce inflammation or improve symptoms, and results may not apply to everyone with back pain or depression.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Massachusetts General Hospital
RECRUITINGBoston, Massachusetts, 02114, United States
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