Can CBD cool brain inflammation and ease back pain and depression?
NCT ID NCT05066308
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether cannabidiol (CBD), a non-intoxicating compound from cannabis, can reduce inflammation in the brain. Researchers will give CBD or a placebo to 80 adults with chronic low back pain, with or without mild-to-moderate depression. They will use brain scans to measure changes in inflammation and see if symptoms improve.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
cannabidiol (CBD) oral solution
What this could lead to
If it works, this could point toward a new way to treat chronic back pain and depression by reducing brain inflammation.
What could go wrong
This is a small, early-stage trial. CBD may not reduce inflammation or improve symptoms, and results may not apply to everyone with back pain or depression.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Massachusetts General Hospital
RECRUITINGBoston, Massachusetts, 02114, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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