DEPRESSIVE SYMPTOMS

This study tests whether combining repetitive transcranial magnetic stimulation (rTMS) with aerobic exercise can improve thinking skills, mood, and walking ability in older adults who have mild cognitive impairment and depression. Participants, aged 65 to 90, will be randomly ass…

This pilot study is testing whether combining cognitive behavioral therapy (CBT) with guided exercise can improve blood sugar control, reduce depression, and boost quality of life in Black men with type 2 diabetes. Eighty participants will receive 8 sessions of CBT, with half als…

This pilot study tests a depression prevention program called Brief Interpersonal Psychotherapy-Adolescent Skills Training (B-IPT-AST) for teens aged 13-17 with mild symptoms. The program includes 6 sessions (4 group, 2 individual) and is compared to usual services. Researchers w…

This study tests whether taking part in racial justice activism can prevent depression and reduce physical stress in Black and Latinx young people aged 15-20. Researchers will measure mood, stress hormones, and health markers over two years. The goal is to see if activism can be …

This study tests a school-based program to prevent depression and suicide in teenagers attending special education schools in the Netherlands. About 236 students with mild depressive symptoms will either receive a cognitive behavioral therapy group training or be monitored. Teach…

This study tests a program called Family Spirit Strengths (FSS) designed to help American Indian and Alaska Native mothers and caregivers cope with stress, build skills, and connect with their culture. About 188 participants will either receive FSS or a nutrition education progra…

This study is testing whether lifestyle changes—like following a Mediterranean diet, exercising regularly, or doing cognitive training—can prevent cognitive decline and improve mood in people aged 50 to 80 who have depressive symptoms or major depression but no current memory pro…

This study tests a culturally tailored web app (CAI) designed to help Asian American breast cancer survivors better manage cancer pain and related depressive symptoms. Researchers will enroll 300 women of Chinese, Korean, or Japanese descent who have had breast cancer and experie…

This study tests a program called SPARK for adults aged 50 and older who have pain, depressive symptoms, and trouble moving around. Participants receive 8 nurse visits at home to help them cope with pain and improve their mood. The goal is to see if this approach reduces pain int…

This study tests an online program called My Wellbeing Guide for cancer patients who feel depressed or anxious. The program uses videos, activities, and written tips based on cognitive behavioral therapy over 7 weeks. About 6,500 participants will be randomly assigned to the prog…

This study tests a telemedicine-delivered cognitive behavioral program (RxWell) to help adults with anxiety or depression use fewer opioids after knee or hip replacement. About 150 participants will be enrolled. The program aims to improve mood and reduce painkiller use by provid…

This study is testing a mobile app called MAYA that teaches cognitive behavioral therapy (CBT) skills to help older adults manage anxiety and depression. About 60 participants aged 40 and older with an anxiety or depressive disorder will use the app for at least 20 minutes, twice…

This study tests a mobile app called Moodivate that helps people with incurable cancer track their daily activities and mood, and suggests new activities to improve their mood. About 279 participants will be randomly assigned to use the app or receive usual care for 8 weeks, with…

This study looks at how stress and sleep affect the mood and brain health of people caring for a loved one with dementia. About 120 caregivers aged 55 and older will receive one of two types of talk therapy. Researchers will track their mood, activity, and brain scans to see whic…

This study tests a new approach for people with depression that hasn't improved with standard treatments. It combines a type of brain stimulation called iTBS with digital mindfulness training to help improve mood and thinking skills. About 120 adults with moderate to severe depre…

This study tests a smartphone app that prompts people with depression to reach out to friends or family for support at the right moments. Over 21 days, 120 adults awaiting therapy will be randomly assigned to different versions of the app or no app at all. The goal is to see if t…

This study is testing whether a non-invasive procedure called repetitive transcranial magnetic stimulation (rTMS) can safely reduce depressive symptoms in U.S. military service members and veterans who have had a concussion or mild traumatic brain injury. About 198 participants w…

This study tests whether a non-invasive brain stimulation technique called MRI-guided transcranial direct current stimulation (tDCS) can reduce depression and apathy in people with Parkinson's disease. Forty participants will receive either real or sham stimulation, and researche…

This study tests a coaching program called POSTCARE-O for women with ovarian cancer who have finished their initial treatment. The program provides support during the transition to survivorship, focusing on quality of life and emotional well-being. 120 women will be randomly assi…

This pilot study is testing whether psilocybin, the active ingredient in magic mushrooms, can safely help depression in people with mild cognitive impairment or early Alzheimer's disease. Twenty participants will receive one or two doses under supportive conditions. Researchers w…

This study tests whether a relaxation technique called progressive muscle relaxation (PMR) — done with or without virtual reality (VR) — can ease chronic symptoms like pain, itch, anxiety, and sleep problems in adult burn survivors. About 34 participants will try both VR-enhanced…

This study is testing whether two devices used together can help new mothers with both depression and urinary incontinence. One device uses magnetic pulses to stimulate brain areas linked to mood, while the other strengthens pelvic floor muscles with electromagnetic energy. Sixty…

This study is testing whether two devices used together can help perimenopausal and postmenopausal women with depression and sexual issues. One device delivers magnetic pulses to the brain (EXOMIND), and the other stimulates the pelvic floor muscles (EMSELLA). Sixty women aged 40…

This study tests whether cannabidiol (CBD), a non-intoxicating compound from cannabis, can reduce inflammation in the brain. Researchers will give CBD or a placebo to 80 adults with chronic low back pain, with or without mild-to-moderate depression. They will use brain scans to m…

This study is testing whether a brief, therapist-guided expressive writing program can reduce symptoms of depression and anxiety in sexual minority veterans. Participants will complete three writing sessions focused on minority stress. The goal is to see if this approach is feasi…

This study is testing an 8-week group program that teaches meditation, breathing, and relaxation skills to help medical graduate students manage mood symptoms like anxiety and depression. About 60 students with mild-to-moderate symptoms will participate. The goal is to see if the…

This study tests whether a sleep hygiene education program can improve sleep quality and reduce depression in menopausal women. 500 women will be randomly assigned to receive the education or be in a control group. The program is based on the IMB model and delivered online. The g…

This study tests a culturally and language-adapted internet-based cognitive behavioral therapy (i-CBT) for Farsi/Dari-speaking youth migrants and refugees aged 15-29. The goal is to reduce symptoms of common mental health problems like anxiety, depression, and stress. Participant…

This study tests whether a music therapy approach called therapeutic songwriting can improve mental health and social connections in university students who feel depressed, anxious, or stressed. Twenty participants will be randomly assigned to either four individual songwriting s…

This study tests whether doing tai chi/qigong over Zoom twice a week for 12 weeks can reduce depressive symptoms in people aged 50-75 living with HIV. About 326 participants will be randomly assigned to either tai chi or a health education class. Researchers will track mood, hear…

This study follows 500 adults already receiving care for depression, bipolar disorder, or suicide risk at the NIH. Researchers will conduct weekly interviews and optional tests like blood draws and brain scans to track symptoms and treatment responses. The goal is to better under…

This study follows 2,500 adults aged 30-75 in Puerto Rico to track chronic diseases like heart disease, diabetes, and obesity. Researchers will collect data on diet, stress, and lifestyle over two years to identify trends and risk factors. The goal is to guide public health prior…

This study is observing 500 adults with type 2 diabetes to understand how their mental well-being, depression, and quality of life are connected. Participants will fill out questionnaires about their feelings and daily life. The goal is to find patterns that can help doctors offe…

This study looks at whether mindfulness-based cognitive therapy (MBCT) can improve how the brain controls emotions in people with mild depression symptoms. 76 adults with depression in remission will be randomly assigned to either MBCT or a wellness program. Researchers will use …

This study looks at whether bright light therapy can help reduce depressive symptoms in adults with intellectual disabilities. Researchers will see how acceptable and practical this treatment is in two care organizations. About 105 participants, including staff and patients, will…

This study talks to children aged 8-12 who have depressive symptoms, and their parents, to learn about their daily stresses and how they cope. The goal is to use this information to design a smartphone app that uses games to teach emotion regulation skills. Only 15 children and t…