DEPRESSIVE SYMPTOMS

This study looks at whether combining guided exercise with cognitive behavioral therapy (CBT) can help Black men with type 2 diabetes and depressive symptoms improve their blood sugar control and quality of life. About 80 men will take part in a 7-month program that includes week…

This study looks at whether lifestyle changes—like regular exercise, cognitive training, and a Mediterranean diet—can help prevent memory and thinking problems in people aged 50 to 80 who have depression or depressive symptoms but no current cognitive decline. Researchers will co…

This study tests whether taking part in racial justice activism can prevent depression and reduce physical stress in Black and Latinx youth aged 15-20. Researchers will measure mood, stress hormones, and health markers in 300 participants over two years. The goal is to see if act…

This study is for people with depression that hasn't improved with medication. It combines a type of brain stimulation called iTBS with digital mindfulness training to help improve mood and thinking. The goal is to see if this combination works better than brain stimulation alone…

This study is testing a web-based app designed to help Asian American breast cancer survivors better manage cancer pain and related depressive symptoms. The app provides information, coaching, and support tailored to each person's needs. Researchers will compare the new app to an…

This study is testing whether cannabidiol (CBD), a non-intoxicating compound from cannabis, can reduce inflammation in the brain for people with chronic low back pain, with or without mild-to-moderate depression. About 80 adults will receive either CBD or a placebo for a period o…

This study tests an online program called My Wellbeing Guide for cancer patients who feel depressed or anxious. Over 6,500 participants will use either the guide (with videos and activities) or a control app with resource links. The goal is to see if the program reduces depressiv…

This study tests whether a telemedicine-delivered cognitive behavioral program (RxWell) can help patients use fewer opioid painkillers after knee or hip replacement. About 150 adults with mild to moderate anxiety or depression symptoms will be enrolled. The program aims to improv…

This study looks at whether music therapy can improve mental health and social connections in university students who feel depressed, anxious, or stressed. Twenty students aged 18-40 will be randomly assigned to either music therapy sessions or non-therapeutic music listening. Re…

This study tests whether a relaxation technique called progressive muscle relaxation (PMR) — done with or without virtual reality (VR) — can help adult burn survivors manage ongoing symptoms like pain, itch, anxiety, sleep problems, and fatigue. About 34 participants will try bot…

This study tests a smartphone app that sends timely prompts to help adults with depression connect with others for emotional or practical support. Over 21 days, 120 participants will be tracked daily to see if the app reduces depressive symptoms and loneliness. The goal is to fin…

This study tests an 8-week group program that teaches mind-body skills like meditation, guided imagery, and relaxation techniques to help medical graduate students manage mood symptoms. About 60 students with mild anxiety or depression will participate. The goal is to see if the …

This study tests a smartphone app called Moodivate designed to help with depression in adults who have incurable cancer and feel down. About 279 participants will be randomly assigned to use the app or not for 12 weeks. Researchers will track changes in mood, anxiety, and quality…

This study tests two types of repetitive transcranial magnetic stimulation (rTMS) to see if they can safely reduce depression in U.S. military service members and veterans who have had a concussion or mild traumatic brain injury. About 198 participants will receive one of the two…

This study tests whether two devices (EXOMIND and EMSELLA) used together can improve depressive symptoms and sexual function in women aged 40 and older who are in perimenopause or menopause. Participants will receive twelve treatments and complete questionnaires about their mood,…

This study is testing whether two devices, EXOMIND and EMSELLA, used together can help improve depressive symptoms and urinary incontinence in women who gave birth within the last 5 years. About 60 women will receive 12 treatment sessions and complete questionnaires about their m…

This study enrolls 120 women with ovarian cancer who have finished their initial treatment. It tests a special survivorship care program (POSTCare-O) designed to provide support during the transition after treatment. Participants are randomly assigned to receive the program or us…

This study tests a culturally adapted internet-based therapy (i-CBT) for Farsi/Dari-speaking migrants and refugees aged 15-29 who have symptoms of anxiety, depression, or stress. Participants will receive the therapy or be in a control group. The goal is to see if this approach r…

This study tests whether doing tai chi and qigong online can reduce depressive symptoms in people aged 50-75 living with HIV. Participants will take either a 12-week tai chi class or a health education class, both via Zoom. Researchers will compare the groups to see if tai chi im…

This study tests whether a special sleep education program can improve sleep quality and reduce depression in menopausal women. 500 women will be randomly assigned to either receive the education or be in a control group. The program teaches about sleep, motivation, and skills to…

This study tests whether a gentle, MRI-guided electrical brain stimulation (called mgTDCS) can improve depression, apathy, and working memory in people with Parkinson's disease. About 40 participants with Parkinson's and elevated depression will receive either real or sham stimul…

This study tests a program called Family Spirit Strengths to help American Indian and Alaska Native mothers and caregivers manage depression, anxiety, and substance use. About 188 pregnant women or caregivers of young children who have mental health symptoms will take part. Half …

This study tests a simple, 3-session writing program to help sexual minority veterans cope with stress related to their identity and reduce symptoms of depression and anxiety. About 85 veterans who identify as gay, lesbian, bisexual, or queer and have significant distress will pa…

This small pilot study is testing whether psilocybin, a hallucinogenic drug, can safely help with depression in people who have mild cognitive impairment or early Alzheimer's disease. Twenty participants will receive the drug in a supportive setting. The study will measure change…

This study is following 2,500 adults aged 30-75 in Puerto Rico to learn how stress, diet, and where they live affect chronic diseases like heart disease, diabetes, and obesity. Researchers will collect health data and survey participants over two years, including before and after…

This study looks at whether bright light therapy can help reduce depressive symptoms in adults with intellectual disabilities. Many standard treatments are hard to use for this group, but light therapy is simple and has shown promise without serious side effects. The study will t…

This study aims to learn more about how depression, bipolar disorder, and suicide risk affect people and how treatments work. Researchers will follow 500 adults already receiving care at the NIH, using interviews, questionnaires, and optional tests like blood draws and brain scan…

This study talks to 15 children aged 8–12 who have depressive symptoms, and their parents, to learn what everyday stresses they face and how they cope. The goal is to use this information to create a fun app that teaches emotional skills through games. No treatment or medication …

This study is observing 500 adults with type 2 diabetes to understand how their mental well-being, depression, and quality of life are related. Participants will fill out questionnaires about their feelings and daily life. The goal is to find patterns that can help doctors offer …

This study compares two programs—Mindfulness-Based Cognitive Therapy and a general wellness program—to see which one better helps people with mild depression control their emotions. About 76 adults with low-level depression symptoms will complete surveys, interviews, and computer…