Could a diabetes drug boost antidepressants for weight and mood?

NCT ID NCT07654179

Recruiting now Disease control Sponsor: Riphah International University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 07, 2026 · Updated 3 times

Summary

This study tests whether adding the diabetes drug metformin to standard antidepressants helps people with both depression and obesity lose weight and feel better. Researchers will also check if certain gene variants affect how well the combination works. The trial involves 200 adults in Pakistan and lasts up to 3 months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Metformin (added to antidepressant therapy)
What this could lead to: If successful, adding metformin to antidepressants could become a simple, low-cost way to improve both mood and weight in people with depression and obesity.
What could go wrong: This is a small, early-stage study (200 people) with no placebo control, so results may not be conclusive. Genetic findings may not apply to other populations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Depression depressive disorder Obesity obesity disorder Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEPRESSION DEPRESSIVE DISORDER DEPRESSIVE SYMPTOMS OVERWEIGHT OR OBESITY

Contacts and locations

Locations

Afifa Siddique
RECRUITING

Rawalpindi, Punjab Province, Pakistan
Pakistan Railway Hospital
RECRUITING

Rawalpindi, Punjab Province, 44000, Pakistan

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