Could a diabetes drug boost antidepressants for weight and mood?
NCT ID NCT07654179
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether adding the diabetes drug metformin to standard antidepressants helps people with both depression and obesity lose weight and feel better. Researchers will also check if certain gene variants affect how well the combination works. The trial involves 200 adults in Pakistan and lasts up to 3 months.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Metformin (added to antidepressant therapy)
What this could lead to
If successful, adding metformin to antidepressants could become a simple, low-cost way to improve both mood and weight in people with depression and obesity.
What could go wrong
This is a small, early-stage study (200 people) with no placebo control, so results may not be conclusive. Genetic findings may not apply to other populations.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Pakistan Railway Hospital
Rawalpindi, Punjab Province, 44000, Pakistan