Magic mushroom compound tested for Alzheimer's depression
NCT ID NCT04123314
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This pilot study is testing whether psilocybin, the active ingredient in magic mushrooms, can safely help depression in people with mild cognitive impairment or early Alzheimer's disease. Twenty participants will receive one or two doses under supportive conditions. Researchers will measure changes in depression symptoms and quality of life over the study period.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
psilocybin
What this could lead to
If it works, this could point toward a new way to ease depression and improve quality of life for people with early Alzheimer's or mild cognitive impairment.
What could go wrong
This is a very small, early-phase pilot study with only 20 participants, so results may not apply to everyone. Psilocybin can cause intense psychological effects and is not yet proven safe or effective for this group.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Johns Hopkins Center for Psychedelic and Consciousness Research
RECRUITINGBaltimore, Maryland, 21224, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact