DEPRESSIVE SYMPTOMS
Clinical trials for DEPRESSIVE SYMPTOMS explained in plain language.
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Mail-Order fitness plan tested on 50,000 women to fight heart disease and falls
Disease control CompletedThis large study tested whether sending exercise guides and motivational tips through the mail could help older women become more active and improve their health. It enrolled nearly 50,000 women aged 60+ to see if this remote program could reduce serious health problems like hear…
Matched conditions: DEPRESSIVE SYMPTOMS
Phase: NA • Sponsor: Fred Hutchinson Cancer Center • Aim: Disease control
Last updated Mar 25, 2026 14:07 UTC
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Can therapy break the cycle of prison? new program aims to help young men stay out
Disease control CompletedThis study tested a program called RISE, designed to help young men leaving prison. It provided therapy for past trauma and support for finding jobs and housing. Researchers wanted to see if this approach improved mental health and community stability, and reduced the chances of …
Matched conditions: DEPRESSIVE SYMPTOMS
Phase: NA • Sponsor: Florida State University • Aim: Disease control
Last updated Mar 20, 2026 14:47 UTC
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Home visitors fight HIV, malnutrition, and depression for rural moms
Disease control CompletedThis study tested whether sending trained community health workers to visit pregnant women at home could improve health for both mothers and their babies. It followed nearly 1,500 women in rural South Africa for a year after giving birth. The program aimed to help with challenges…
Matched conditions: DEPRESSIVE SYMPTOMS
Sponsor: University of California, Los Angeles • Aim: Disease control
Last updated Mar 19, 2026 14:56 UTC
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Hope for youth: community programs tested to stop suicide
Prevention CompletedThis study aimed to find the best way to combine community support programs to prevent suicide and build strength in American Indian youth ages 10-29 who were at risk. Researchers tested different sequences of three approaches: a brief counseling program (New Hope), a cultural co…
Matched conditions: DEPRESSIVE SYMPTOMS
Phase: NA • Sponsor: Johns Hopkins Bloomberg School of Public Health • Aim: Prevention
Last updated Mar 31, 2026 12:12 UTC
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Local fortified food tested to boost health of future mothers
Prevention CompletedThis study tested whether adding folic acid and vitamin B12 to locally produced cereals could prevent deficiencies and improve health in teenage girls in rural Ethiopia. Researchers enrolled 472 girls aged 13-19 and provided them with fortified meals for six months. They measured…
Matched conditions: DEPRESSIVE SYMPTOMS
Phase: NA • Sponsor: University Ghent • Aim: Prevention
Last updated Mar 23, 2026 15:28 UTC
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Massive study tests daily supplements to ward off depression
Prevention CompletedThis large study investigated whether taking daily vitamin D or fish oil supplements could prevent depression in older adults who were not currently depressed. Over 18,000 participants were randomly assigned to take either the real supplements or placebo pills for over five years…
Matched conditions: DEPRESSIVE SYMPTOMS
Phase: NA • Sponsor: Brigham and Women's Hospital • Aim: Prevention
Last updated Mar 17, 2026 12:55 UTC
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Virtual mentors step in to shield trans youth from harm
Prevention CompletedThis pilot study tested a new online program called the Teen Connection Project. It paired 56 transgender and gender-diverse teens (ages 14-18) with adult mentors from similar backgrounds for seven group sessions. The goal was to see if building social and emotional skills throug…
Matched conditions: DEPRESSIVE SYMPTOMS
Phase: NA • Sponsor: University of Michigan • Aim: Prevention
Last updated Mar 09, 2026 14:23 UTC
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One hour vs ten weeks: which talk therapy works better for everyday worries?
Symptom relief CompletedThis study tested two different talk therapy approaches for adults experiencing mild anxiety and depression symptoms. Researchers compared a 10-week group therapy program against a single one-hour counseling session to see which helped more. The goal was to reduce symptoms and se…
Matched conditions: DEPRESSIVE SYMPTOMS
Phase: NA • Sponsor: University of Alcala • Aim: Symptom relief
Last updated Apr 01, 2026 14:43 UTC
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Digital therapy tested to help young refugees cope with trauma and stress
Symptom relief CompletedThis study tested whether an online therapy program, specially adapted for Arabic-speaking refugee and migrant youth, could help reduce symptoms of anxiety, depression, and trauma. The program used internet-based cognitive behavioral therapy (iCBT) over 6-10 weeks. Researchers co…
Matched conditions: DEPRESSIVE SYMPTOMS
Phase: NA • Sponsor: Karolinska Institutet • Aim: Symptom relief
Last updated Apr 01, 2026 14:42 UTC
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Virtual support group aims to ease the mental burden on rare disease parents
Symptom relief CompletedThis study tested a 5-week online group program designed to help parents and guardians of children with rare diseases. The program, called Rare Group Problem Management Plus, aimed to provide practical and emotional support to manage stress, anxiety, and depression. Participants …
Matched conditions: DEPRESSIVE SYMPTOMS
Phase: NA • Sponsor: Children's National Research Institute • Aim: Symptom relief
Last updated Apr 01, 2026 14:42 UTC
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Phone therapy eases cancer Survivors' anxiety and depression
Symptom relief CompletedThis study tested a phone-based therapy program to help rural cancer survivors manage mental health challenges after treatment. Researchers offered different levels of support based on each person's symptoms, using workbooks and phone sessions. The goal was to reduce anxiety, dep…
Matched conditions: DEPRESSIVE SYMPTOMS
Phase: NA • Sponsor: Wake Forest University Health Sciences • Aim: Symptom relief
Last updated Apr 01, 2026 14:42 UTC
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Can online videos ease the mental burden of a chronic disease?
Symptom relief CompletedThis study tested whether a short online video program could improve mental health and quality of life for people living with myasthenia gravis, a chronic autoimmune disease. Seventy-seven patients watched four video lessons focused on building support, managing emotions, and fin…
Matched conditions: DEPRESSIVE SYMPTOMS
Phase: NA • Sponsor: Jiann-Horng Yeh • Aim: Symptom relief
Last updated Apr 01, 2026 14:41 UTC
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New therapy aims to heal minds after devastating earthquakes
Symptom relief CompletedThis study tested a special group therapy program designed to help survivors of the 2023 Turkey earthquakes. The program, called Culturally Adapted Cognitive Behavioral Therapy (CA-CBT), aimed to reduce psychological distress and depression while improving well-being. Researchers…
Matched conditions: DEPRESSIVE SYMPTOMS
Phase: NA • Sponsor: Koç University • Aim: Symptom relief
Last updated Mar 31, 2026 12:12 UTC
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Can a phone call get you moving and lift your mood?
Symptom relief CompletedThis study tested a new phone-based therapy program designed to help people with depression become more physically active. 65 adults with moderate to severe depression who exercised very little received 10 therapy sessions by phone or video. Researchers wanted to see if this appr…
Matched conditions: DEPRESSIVE SYMPTOMS
Phase: NA • Sponsor: University of Texas Southwestern Medical Center • Aim: Symptom relief
Last updated Mar 30, 2026 14:35 UTC
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Can prayer in your pocket ease student stress? app trial investigates
Symptom relief CompletedThis study tested whether using a faith-based mobile app (PRAY.COM) could help improve mental health and well-being for university students. 450 students were asked to use the app for at least 10 minutes daily for 8 weeks. Researchers measured if students found the app useful and…
Matched conditions: DEPRESSIVE SYMPTOMS
Phase: NA • Sponsor: Fit Minded • Aim: Symptom relief
Last updated Mar 30, 2026 14:34 UTC
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Can listening heal depression? new audio therapy study
Symptom relief CompletedThis study tested whether listening to special audio programs could help reduce symptoms of depression. 101 adults with moderate to severe depression were randomly assigned to listen to one of two different audio-based programs for two weeks. Researchers measured changes in depre…
Matched conditions: DEPRESSIVE SYMPTOMS
Phase: NA • Sponsor: Penn State University • Aim: Symptom relief
Last updated Mar 30, 2026 14:33 UTC
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Can a new type of weight training lift mood and mobility for older women?
Symptom relief CompletedThis study tested whether a newer type of strength training (using a flywheel machine) is better than traditional weight training at reducing feelings of depression and improving physical and mental function in older women who are mostly inactive. Over 10 months, 64 women trained…
Matched conditions: DEPRESSIVE SYMPTOMS
Phase: NA • Sponsor: Federal University of Vicosa • Aim: Symptom relief
Last updated Mar 30, 2026 14:31 UTC
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Can daily texts help kids fight Cancer's mental toll?
Symptom relief CompletedThis study tested whether a 12-week phone app could help children with cancer and their families build mental resilience. Forty participants, including kids with new cancer diagnoses and other chronic illnesses, received daily texts with links to mindfulness and self-reflection e…
Matched conditions: DEPRESSIVE SYMPTOMS
Phase: PHASE1 • Sponsor: Linkoeping University • Aim: Symptom relief
Last updated Mar 30, 2026 14:30 UTC
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Can a daily probiotic pill ease your stress?
Symptom relief CompletedThis study tested whether taking a specific probiotic supplement (Lactobacillus reuteri) could help reduce feelings of stress, anxiety, and depression in adults who report moderate to high stress. 150 participants aged 18-45 were randomly assigned to take either the probiotic or …
Matched conditions: DEPRESSIVE SYMPTOMS
Phase: NA • Sponsor: University of Colorado, Boulder • Aim: Symptom relief
Last updated Mar 23, 2026 15:18 UTC
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Can sniffing scents lift your mood? study investigates
Symptom relief CompletedThis study tested whether daily smell training could improve mood and emotional perception in people with depressive symptoms. 150 participants, including healthy people and those diagnosed with depression, practiced smelling different odors daily for 3 months. Researchers measur…
Matched conditions: DEPRESSIVE SYMPTOMS
Phase: NA • Sponsor: University Hospital, Tours • Aim: Symptom relief
Last updated Mar 23, 2026 15:15 UTC
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Nurses visit homes to fight pain and depression in aging women
Symptom relief CompletedThis small pilot study tested whether eight home visits from a nurse could help older African American women manage chronic pain and depressive symptoms. The program, called DAPPER, combined counseling and practical support to help participants set personal goals for improving th…
Matched conditions: DEPRESSIVE SYMPTOMS
Phase: NA • Sponsor: Johns Hopkins University • Aim: Symptom relief
Last updated Mar 16, 2026 15:26 UTC
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Can art classes chase away the blues for seniors?
Symptom relief CompletedThis study tested whether a 9-week cultural arts program could help reduce feelings of depression and negative self-perceptions related to aging in older adults. Researchers compared 63 older adults who participated in the arts program to a group that received usual services. The…
Matched conditions: DEPRESSIVE SYMPTOMS
Phase: NA • Sponsor: The Hong Kong Polytechnic University • Aim: Symptom relief
Last updated Mar 16, 2026 15:24 UTC
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Phone app fights depression for Stressed-Out caregivers
Symptom relief CompletedThis study tested a mobile phone app designed to help family caregivers of people with dementia. The app taught skills to manage stress and improve mood through simple daily activities. Researchers compared the app to online educational materials to see which better reduced feeli…
Matched conditions: DEPRESSIVE SYMPTOMS
Phase: NA • Sponsor: University of California, San Diego • Aim: Symptom relief
Last updated Mar 13, 2026 15:06 UTC
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Can online therapy heal the invisible wounds of an earthquake?
Symptom relief CompletedThis small, completed pilot study tested whether a specific online talk therapy could help adults in Turkey who were struggling with mental health after the 2023 earthquakes. It compared a 12-session therapy program delivered over video calls to a group receiving standard care. T…
Matched conditions: DEPRESSIVE SYMPTOMS
Phase: NA • Sponsor: Koç University • Aim: Symptom relief
Last updated Mar 09, 2026 14:27 UTC
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Study tracks college stress to find early warning signs
Knowledge-focused CompletedThis University of Michigan study aimed to understand how first-year college students develop and cope with stress and mild depression. Researchers followed 120 students, some receiving weekly check-ins and feedback, to identify opportunities for early support before symptoms wor…
Matched conditions: DEPRESSIVE SYMPTOMS
Phase: NA • Sponsor: University of Michigan • Aim: Knowledge-focused
Last updated Mar 31, 2026 12:12 UTC
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Scientists track daily mood and blood sugar to map diabetes distress
Knowledge-focused CompletedThis study aimed to understand how mental health conditions like depression and anxiety affect blood sugar control in people with type 1 or type 2 diabetes. Researchers followed 1,290 participants for two years, using smartphone surveys and glucose monitors to track daily moods, …
Matched conditions: DEPRESSIVE SYMPTOMS
Sponsor: Forschungsinstitut der Diabetes Akademie Mergentheim • Aim: Knowledge-focused
Last updated Mar 27, 2026 12:41 UTC
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Can a cup of blueberries fight inflammation in aging?
Knowledge-focused CompletedThis small pilot study tested whether eating different amounts of blueberry powder (equal to 1 or 2 cups of fresh blueberries) affects how older adults absorb healthy plant compounds and whether it changes markers of inflammation in their blood. Six older adults with mild depress…
Matched conditions: DEPRESSIVE SYMPTOMS
Phase: NA • Sponsor: Hebrew SeniorLife • Aim: Knowledge-focused
Last updated Mar 27, 2026 12:39 UTC
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Can breaking a negative thought loop protect your heart?
Knowledge-focused CompletedThis small, completed study explored whether a specific type of talk therapy could improve both mental and physical health. It tested Rumination-Focused Cognitive Behavioral Therapy (RFCBT), which helps people manage repetitive negative thoughts, in nine low-income adults with mi…
Matched conditions: DEPRESSIVE SYMPTOMS
Phase: NA • Sponsor: University of Louisville • Aim: Knowledge-focused
Last updated Mar 24, 2026 12:01 UTC