Could aspirin and ketamine be the next depression breakthrough?
NCT ID NCT05615948
First seen Jun 24, 2026 · Last updated Jun 24, 2026
Summary
This small study tested whether taking aspirin and ketamine together by mouth can help people with treatment-resistant depression. Fifteen adults who had not gotten better with standard antidepressants received the combination alongside their usual medication. Researchers measured changes in depression symptoms using a standard rating scale over one week.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Maimonides Medical Center
Brooklyn, New York, 11219, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
a combination of aspirin and ketamine taken by mouth
What this could lead to
If it works, this could offer a new, easy-to-take option for people with depression that hasn't responded to standard antidepressants.
What could go wrong
This was a very small, open-label study with only 15 people, so results may not apply widely. The combination has not been tested in larger, more rigorous trials.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.