Could aspirin and ketamine be the next depression breakthrough?
NCT ID NCT05615948
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This small study tested whether taking aspirin and ketamine together by mouth can help people with treatment-resistant depression. Fifteen adults who had not gotten better with standard antidepressants received the combination alongside their usual medication. Researchers measured changes in depression symptoms using a standard rating scale over one week.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- a combination of aspirin and ketamine taken by mouth
- What this could lead to
- If it works, this could offer a new, easy-to-take option for people with depression that hasn't responded to standard antidepressants.
- What could go wrong
- This was a very small, open-label study with only 15 people, so results may not apply widely. The combination has not been tested in larger, more rigorous trials.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Maimonides Medical Center
Brooklyn, New York, 11219, United States
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