KETAMINE

This study tests two fast-acting approaches to prevent suicide in teens and adults who recently attempted suicide or have severe suicidal thoughts. One group receives a single intravenous dose of esketamine, another gets a one-on-one crisis planning session, and a third gets enha…

This study tests whether a new drug called HNK can quickly improve symptoms in people with major depression that hasn't responded to other treatments. About 50 adults aged 18 to 70 will receive four infusions of HNK and four of a placebo over several weeks, with their depression …

This study looks at whether a low dose of ketamine, given as an IV infusion, can quickly improve depressive symptoms in adults who have been in the intensive care unit (ICU) for at least 6 days. About 50 participants will receive either ketamine or a placebo on two days in a row.…

This study tests whether inhaling ketamine through a nebulizer can quickly reduce symptoms of moderate to severe depression in hospitalized adults. About 40 participants will receive either ketamine or a placebo (midazolam) and be monitored for changes in depression scores over 8…

This study follows 500 adults already receiving care for depression, bipolar disorder, or suicide risk at the NIH. Researchers will conduct weekly interviews and optional tests like blood draws and brain scans to track symptoms and treatment responses. The goal is to better under…

This study looks back at medical records of critically ill adults in the ICU to compare two common sedation drugs (propofol and ketamine) used before placing a breathing tube. Researchers want to see if one drug is linked to better survival at 7 days and fewer complications like …

This study compares two drug combinations (ketamine-lidocaine vs ketamine-fentanyl) used to put patients to sleep before heart bypass surgery. The goal is to see which combination better maintains blood flow to the brain during the procedure. The study includes 40 adults with cor…

This study compares four different anesthesia techniques during sinus surgery to see which one keeps the brain safest and provides the best surgical conditions. Researchers will measure brain injury markers in the blood and rate bleeding during surgery. 150 adults undergoing sinu…