Could a low dose of ketamine protect your heart during eye surgery?

NCT ID NCT07708740

Recruiting now Symptom relief Sponsor: Cairo University Source: ClinicalTrials.gov ↗

First seen Jul 16, 2026 · Last updated Jul 17, 2026 · Updated 1 time

Summary

This trial investigates whether a low dose of ketamine (0.5 mg/kg) can prevent the oculocardiac reflex — a sudden drop in heart rate that can occur when eye muscles are pulled during surgery — as effectively as a higher dose (0.75 mg/kg). The study involves 40 adults aged 18 to 65 undergoing planned eye surgery under general anesthesia. Researchers will compare how often the reflex occurs in each group and monitor heart rates throughout the procedure.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ketamine hydrochloride given intravenously
What this could lead to: If successful, this could establish a safer, lower dose of ketamine to prevent dangerous heart-rate drops during eye surgery.
What could go wrong: This is a small, early-stage trial with only 40 participants, so results may not apply to all patients. The higher dose may work better, or neither dose may be effective.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

KETAMINE OCULOCARDIAC REFLEX OPHTHALMIC SURGERY

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Cairo University
RECRUITING

Cairo, 12613, Egypt

Contact Phone: •••-•••-•••• Email: •••••@•••••

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