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Could a low dose of ketamine protect your heart during eye surgery?

NCT ID NCT07708740

Symptom relief Sponsor: Cairo University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 16, 2026 · Last updated Jul 17, 2026 · Updated 1 time

Summary

This trial investigates whether a low dose of ketamine (0.5 mg/kg) can prevent the oculocardiac reflex — a sudden drop in heart rate that can occur when eye muscles are pulled during surgery — as effectively as a higher dose (0.75 mg/kg). The study involves 40 adults aged 18 to 65 undergoing planned eye surgery under general anesthesia. Researchers will compare how often the reflex occurs in each group and monitor heart rates throughout the procedure.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
ketamine hydrochloride given intravenously
What this could lead to
If successful, this could establish a safer, lower dose of ketamine to prevent dangerous heart-rate drops during eye surgery.
What could go wrong
This is a small, early-stage trial with only 40 participants, so results may not apply to all patients. The higher dose may work better, or neither dose may be effective.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 40 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2026

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age from 18 to 65 years old. * Both sexes. * American Society of Anesthesiologists (ASA) physical status I, II. * Scheduled for elective ophthalmic surgery involving extraocular muscle traction under general anesthesia. Exclusion Criteria: * Ketamine contraindications (e.g., hypersensitivity, uncontrolled hypertension) * History of cardiac arrhythmia or conduction disorder * Glaucoma or raised intraocular pressure * ASA status greater than II * Patient refusal.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Ketamine Oculocardiac reflex Ophthalmic surgery

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • Cairo University

    RECRUITING

    Cairo, 12613, Egypt

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