KETAMINE

This study tests a new drug called (2R,6R)-HNK to see if it can quickly improve symptoms in people with major depression that hasn't responded to other treatments. About 50 adults aged 18 to 70 will receive four infusions of HNK and four of a placebo over several weeks, with thei…

This study tests whether inhaling ketamine through a nebulizer can reduce symptoms of moderate to severe depression in hospitalized adults. Forty participants will receive either ketamine or an active placebo (midazolam) and be monitored for changes in depression scores over abou…

This study looks back at medical records of critically ill adults in the ICU who needed a breathing tube. Researchers want to see if the type of medicine used to sedate them before intubation affects their chance of dying within a week. The goal is to find out which drug is safes…

This study aims to learn more about how depression, bipolar disorder, and suicide risk affect people and how treatments work. Researchers will follow 500 adults already receiving care at the NIH, using interviews, questionnaires, and optional tests like blood draws and brain scan…

This study looks at two different drug combinations used to put patients to sleep before heart bypass surgery. The goal is to see which one better keeps blood flowing to the brain during the procedure. The study includes 40 adults with heart disease and weak heart pumping functio…

This study looks at four different types of anesthesia used during sinus surgery to find out which one keeps the brain safest and gives surgeons the best view. 150 adults having sinus surgery will be randomly assigned to one of four anesthesia groups. Researchers will measure bra…